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公开(公告)号：US20050026214A1
公开(公告)日：2005-02-03
申请号：US10489034
申请日：2002-09-02
IPC分类号： G01N33/50 , A61K45/00 , A61P31/04 , C12N9/10 , C12N15/09 , C12Q1/48 , G01N33/15 , G01N33/573 , G01N33/68 , G01N33/53
CPC分类号： G01N33/6845 , C12Q1/48 , G01N33/68
摘要： The present invention relates to a method of identifying, screening or selecting a compound which binds to the transglycosylation site of a recombinant glycosyl transferase, comprising the steps consisting in: a) bringing said compound into contact with said recombinant protein before, after or at the same time as said recombinant protein is brought into contact with a transglycosylation activity inhibitor, said inhibitor being labeled with a label that generates a direct or indirect signal, b) studying said signal linked to said recombinant protein, the binding of said compound to the transglycosylation site being deduced from the difference between the signal obtained in step b) and the signal obtained in the absence of said compound.
摘要翻译： 本发明涉及鉴定，筛选或选择与重组糖基转移酶的转糖基化位点结合的化合物的方法，其包括以下步骤：a）使所述化合物与所述重组蛋白质在之前或之后接触 与所述重组蛋白质与转糖基化活性抑制剂接触的同时，所述抑制剂用产生直接或间接信号的标记进行标记，b）研究与所述重组蛋白相连的所述信号，所述化合物与转糖基化的结合 从步骤b）中获得的信号与在不存在所述化合物的情况下获得的信号之间的差异推断出位点。
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公开(公告)号：US4865767A
公开(公告)日：1989-09-12
申请号：US797140
申请日：1985-12-19
IPC分类号： A61K51/00 , C07J1/00 , G01N33/534 , G01N33/74
CPC分类号： C07J1/0048 , C07J1/0011 , G01N33/534 , G01N33/743
摘要： Novel radioactive steroids labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms useful for revealing receptors of glucocorticoids and in determining the number of fixation sites of glucocorticoids and novel intermediates.
摘要翻译： 新型放射性类固醇用式Ⅺ标记的氚，其中3H是氚，R和R 1分别选自氢，1至6个碳原子的烷基和1至10个碳原子的有机羧酸的酰基 可用于揭示糖皮质激素受体的原子和确定糖皮质激素和新型中间体的固定位点的数量。
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公开(公告)号：US4664850A
公开(公告)日：1987-05-12
申请号：US620457
申请日：1984-06-14
IPC分类号： A61K51/00 , C07J1/00 , G01N33/534 , G01N33/74
CPC分类号： C07J1/0048 , C07J1/0011 , G01N33/534 , G01N33/743
摘要： Novel radioactive steriods labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms useful for revealing receptors of glucocorticoids and in determining the number of fixation sites on glucocorticoids and novel intermediates.
摘要翻译： 新型放射性放射性标记物，其具有下式的氚：其中3H是氚，R和R 1分别选自氢，1至6个碳原子的烷基和1至10个碳的有机羧酸的酰基 可用于揭示糖皮质激素受体的原子和确定糖皮质激素和新型中间体的固定位点数。
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公开(公告)号：US4661295A
公开(公告)日：1987-04-28
申请号：US620454
申请日：1984-06-14
申请人： Alain Jouquey , Jean-Noel Veltz , Jean Salmon , Michel Mouren
发明人： Alain Jouquey , Jean-Noel Veltz , Jean Salmon , Michel Mouren
IPC分类号： G01N33/53 , A61K51/00 , A61K51/04 , C07J1/00 , C07J9/00 , C07J21/00 , C07J41/00 , C07J43/00 , G01N33/534 , G01N33/74
CPC分类号： A61K51/0493 , C07J41/0016 , C07J41/0083 , G01N33/534 , G01N33/743 , A61K2123/00
摘要： Novel radioactive estradienes labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms and the study and radioimmunological determination of non-radioactive 11.beta.-(4-dimethylaminophenyl)-17.alpha.-(prop-1-ynyl)-.DELTA..sup.4,9 -estradiene-17.beta.-ol-3-one and its metabolites in biological fluids and novel intermediates.
摘要翻译： 用式Ⅺ标示的氚的新型放射性碘化物，其中3H是氚，R选自氢，1至6个碳原子的烷基和1至10个碳原子的有机羧酸的酰基， 研究和放射免疫测定非放射性11β-（4-二甲基氨基苯基）-17α-（丙-1-炔基）-TATA 4,9-雌二烯-17β-醇-3-酮及其在生物液体中的代谢物和 新颖的中间体。
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