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    Novel radioactive estradienes labelled with iodine
    2.
    发明授权
    Novel radioactive estradienes labelled with iodine 失效
    用碘标记的新型放射性碘化物

    公开(公告)号：US4639336A

    公开(公告)日：1987-01-27

    申请号：US620455

    申请日：1984-06-14

    申请人： Alain Jouquey ,  Jean Salmon ,  Michel Mouren ,  Gaetan Touyer

    发明人： Alain Jouquey ,  Jean Salmon ,  Michel Mouren ,  Gaetan Touyer

    IPC分类号： C07J41/00 ,  G01N33/534 ,  G01N33/74 ,  C07J1/00

    CPC分类号： C07J41/0016 ,  C07J41/0083 ,  G01N33/534 ,  G01N33/743 ,  A61K2123/00

    摘要： Novel radioactive estradienes labelled with iodine of the formula ##STR1## in the form of their syn or anti isomers or mixtures thereof wherein the wavy line indicates anti or syn position, R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 12 carbon atoms and R.sub.1 is the residue of an amino acid R.sub.1 NH.sub.2 possessing an iodine acceptor group or a derivative thereof labelled with iodine .sup.125 or .sup.131 and their preparation and novel intermediates, antigens prepared from the compounds of formula I and bovine seric albumin or human seric albumin and their preparation and their use for the preparation of antibodies.

    摘要翻译： 以其顺式或反式异构体或其混合物的形式用碘标记的新型放射性碘化物，其中波浪线表示抗或顺式位置，R选自氢，1至6的烷基 碳原子和碳原子数为1〜12的有机羧酸的酰基，R 1为具有用碘125或131标记的碘受体基团或其衍生物的氨基酸R 1 NH 2的残基及其制备和新型中间体，由 式I化合物和牛血清白蛋白或人血清白蛋白及其制备及其用于制备抗体的用途。

    Novel radioactive estratrienes
    3.
    发明授权
    Novel radioactive estratrienes 失效
    新型放射性三异构体

    公开(公告)号：US4632820A

    公开(公告)日：1986-12-30

    申请号：US560184

    申请日：1983-12-12

    申请人： Alain Jouquey ,  Gaetan Touyer ,  Jean Salmon ,  Michel Mouren

    发明人： Alain Jouquey ,  Gaetan Touyer ,  Jean Salmon ,  Michel Mouren

    IPC分类号： C07J1/00 ,  C07J41/00 ,  G01N33/534 ,  A61K49/00 ,  A61K43/00

    CPC分类号： C07J41/0016 ,  G01N33/534

    摘要： Novel radioactive .DELTA..sup.4,9,11 -estratrienes marked with iodine 125 or 131 having the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 2 to 12 carbon atoms, R.sub.1 is the reminder of an amino acid of the formula R.sub.1 NH.sub.2 or a derivative thereof being marked with iodine 125 or 131 and the wavy lines indicate the --OR is in the .alpha.- or .beta.-position and the oximido group is in the syn or anti position, a process and intermediates for their preparation, antigens prepared therefrom and use thereof to prepare antibodies.

    摘要翻译： 用碘125或131标记的新型放射性DELTA 4,9,11-雌三醇，其具有式I图1其中R选自氢，1至6个碳原子的烷基和2位有机羧酸的酰基 至12个碳原子，R1是式R1NH2的氨基酸或其衍生物用碘125或131标记的波形，波浪线表示-OR为α或β-位，肟基为 在syn或反位置，其制备方法和中间体，由其制备的抗原及其制备抗体的用途。