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    Supports useful in solid phase synthesis of oligonucleotides
    1.
    发明授权
    Supports useful in solid phase synthesis of oligonucleotides 失效
    支持寡核苷酸的固相合成

    公开(公告)号：US4780504A

    公开(公告)日：1988-10-25

    申请号：US871451

    申请日：1986-06-05

    申请人： Jean Buendia ,  Jeanine Nierat

    发明人： Jean Buendia ,  Jeanine Nierat

    IPC分类号： C07H21/04 ,  B01J31/02 ,  C07F7/18 ,  C07H21/00 ,  C12P19/34 ,  C12P19/38

    CPC分类号： C07H21/00

    摘要： Novel supports useful in solid phase synthesis of oligonucleotides of the formula ##STR1## wherein .circle. is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x.sub.1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.

    摘要翻译： 新颖的载体可用于下式的寡核苷酸的固相合成：其中＆cir是选自玻璃，二氧化硅，硅藻土，聚四氟乙烯，纤维素和金属氧化物的材料的微丸，m是 A为1至20的整数，A选自1至20个碳原子的亚烷基，3至12个碳原子的饱和环亚烷基，苯基和5至6个成员杂环，x为0至20的整数，x1 是0至10的整数，并且氨基可以在m-，p-或o-位，制备所述载体的方法，所述载体和中间体的用途。

    Supports and their use
    2.
    发明授权
    Supports and their use 失效
    支持及其使用

    公开(公告)号：US4812512A

    公开(公告)日：1989-03-14

    申请号：US878611

    申请日：1986-06-26

    申请人： Jean Buendia ,  Jeanine Nierat

    发明人： Jean Buendia ,  Jeanine Nierat

    IPC分类号： C07H21/02 ,  C07H21/00 ,  C07H21/04

    CPC分类号： C07H21/00

    摘要： Novel supports useful in solid phase synthesis of oligonucleotides of the formula ##STR1## wherein .circle.P is a material selected from the group consisting of functionalized glass micropellets, silica functionalized by aminoalkyl trialkoxysilane capable of to obtain for ##STR2## Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkyl of 1 to 20 carbon atoms, saturated cycloalkyl of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x and y are an integer from 0 to 20, x.sub.1 is an integer from 1 to 20 and y.sub.1 is an integer from 0 to 10, a process for the preparation of said supports, the use of said supports and intermediates.

    摘要翻译： 新颖的载体可用于固相合成下式的寡核苷酸，其中＆cir＆P是选自官能化的玻璃微丸，由能够获得 Kieselguhr的氨基烷基三烷氧基硅烷官能化的二氧化硅的材料， 聚四氟乙烯，纤维素和金属氧化物，m是1至20的整数，A选自1至20个碳原子的烷基，3至12个碳原子的饱和环烷基，苯基和5至6个成员杂环，x y为0〜20的整数，x1为1〜20的整数，y1为0〜10的整数，制备所述载体的方法，所述载体和中间体的使用。

    Epimerization of trans chrysanthemates
    3.
    发明授权
    Epimerization of trans chrysanthemates 失效
    反式菊花异构化

    公开(公告)号：US4447637A

    公开(公告)日：1984-05-08

    申请号：US347278

    申请日：1982-02-09

    申请人： Jacques Martel ,  Jean Buendia ,  Jeanine Nierat

    发明人： Jacques Martel ,  Jean Buendia ,  Jeanine Nierat

    IPC分类号： C07C69/747 ,  C07C51/353 ,  C07C51/487 ,  C07C61/04 ,  C07C61/37 ,  C07C67/333 ,  C07C69/74 ,  C07C61/18

    CPC分类号： C07C61/37 ,  C07C51/353 ,  C07C51/487

    摘要： A novel process for the epimerization of alkyl trans chrysanthemates comprising reacting at a low temperature in an anhydrous organic solvent an alkyl trans chrysanthemate of the formula ##STR1## of the 1S, trans or 1R, trans configuration wherein R is alkyl of 1 to 6 carbon atoms with a strong alkali metal base to obtain a compound of the formula ##STR2## wherein R has the above definition and M is an alkali metal, reacting the latter compound with a reactant of the formulaY--Awherein A is selected from the group consisting of chlorine, bromine, iodine and anion derived from a hydrogen acid and Y is an organic radical capable of forming a ketal of a ketene to obtain a compound of the formula ##STR3## reacting the latter at a low temperature in an anhydrous organic solvent with a proton donor to obtain a mixture of the corresponding alkyl cis chrysanthemate and alkyl trans chrysanthemate and recovering the cis chrysanthemic acid of the formula ##STR4## with the 1R, cis or 1S, cis configuration.

    摘要翻译： 一种用于烷基反式菊氨酸差向异构化的新方法，其包括在低温下在无水有机溶剂中反应1S，反式或1R，反式构型的式II的烷基反式菊酯，其中R是1至6的烷基 具有强碱金属碱的碳原子以得到式III的化合物，其中R具有上述定义，M是碱金属，使后一化合物与式YA的反应物反应，其中A选自 由氯，溴，碘和由氢酸衍生的阴离子组成，Y是能够形成乙烯酮缩酮的有机基团，得到下式的化合物，其中IV在低温下与无水有机物 溶剂与质子供体反应，得到相应的顺式菊酸菊酯和反式菊酸酯的混合物，并用1R，顺式或1S的方法回收式Ⅰ的顺式菊酸， 顺式配置。