公开(公告)号：US20070073388A1

公开(公告)日：2007-03-29

申请号：US11466439

申请日：2006-08-22

申请人： Jeffrey Krolik ,  Eliot Kim ,  James Dreher

发明人： Jeffrey Krolik ,  Eliot Kim ,  James Dreher

IPC分类号： A61F2/06

CPC分类号： A61F2/958 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/821 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0018 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61M25/1002

摘要： Flared stents are disclosed, and apparatus and methods for delivering such stents into a bifurcation between a main vessel and a branch vessel. The stent includes a first tubular portion a second flaring portion that may be flared radially outwardly to contact the ostium. The stent may include variable mechanical properties along its length. The stent may be delivered using a catheter including proximal and distal ends, the stent overlying first and second balloons on the distal end. During use, the catheter is advanced through an ostium into the branch to place the stent within the branch. The first balloon is expanded to flare the stent to contact a wall of the ostium, thereby causing the stent to migrate partially into the ostium. The second balloon is expanded to filly expand the stent within the ostium and branch.

摘要翻译： 公开了扩口支架，以及用于将这种支架输送到主血管和分支血管之间的分叉中的装置和方法。 支架包括第一管状部分，第二扩张部分可以径向向外张开以接触口。 支架可以包括沿其长度的可变机械特性。 可以使用包括近端和远端的导管递送支架，支架覆盖在远端上的第一和第二气囊。 在使用期间，导管通过口进入分支以将支架置于分支内。 扩张第一个气囊以使支架扩张以接触口的壁，从而使支架部分地迁移到口中。 第二个气球膨胀到在口腔和支管内部扩张支架。

公开(公告)号：US20070055358A1

公开(公告)日：2007-03-08

申请号：US11466448

申请日：2006-08-22

申请人： Jeffrey Krolik ,  Eliot Kim

发明人： Jeffrey Krolik ,  Eliot Kim

IPC分类号： A61F2/06

CPC分类号： A61F2/958 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/821 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0018 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61M25/1002

摘要： A stent includes a flaring portion and a main portion connected to the flaring portion. The main portion includes a plurality of bands of cells spaced apart axially from one another, adjacent bands of cells being intermittently connected to one another. During use, the stent is introduced into a main vessel in a contracted condition and positioned with the flaring portion adjacent an ostium. The flaring portion is flared, and the stent is advanced at least partially into the ostium. The stent is expanded further such that the main portion expands within the branch body lumen and/or the flaring portion expands adjacent the ostium. The main portion compresses axially during at least one of the steps when the stent is expanded, which may enhance conformance of the stent relative to the ostium and/or enhance reinforcement of the ostium.

摘要翻译： 支架包括扩口部分和连接到扩口部分的主要部分。 主要部分包括彼此轴向隔开的多个细胞带，相邻的细胞带彼此间歇地连接。 在使用过程中，将支架以收缩状态引入主容器中，并将扩张部分定位在靠近口的位置。 扩张部分展开，支架至少部分推进到口中。 支架进一步膨胀，使得主要部分在分支体腔内扩张和/或扩张部分在邻近口处扩张。 当支架膨胀时，主要部分在至少一个步骤期间轴向压缩，这可以增强支架相对于口的一致性和/或增强口腔的增强。

公开(公告)号：US10086176B2

公开(公告)日：2018-10-02

申请号：US12966925

申请日：2010-12-13

申请人： Gregory Sampognaro ,  Gwendolyn Watanabe ,  Jeffrey Krolik

发明人： Gregory Sampognaro ,  Gwendolyn Watanabe ,  Jeffrey Krolik

IPC分类号： A61M29/00 ,  A61M25/10 ,  A61B17/22 ,  A61B17/3207 ,  A61M25/06 ,  A61M25/00

摘要： Apparatus and methods are provided for treating a lesion within a body lumen using a catheter including a balloon on its distal end and an abrasive distal tip extending distally beyond the balloon. The distal tip may terminate in a sharpened tip for penetrating occlusive material, e.g., a beveled tip, and includes abrasive material on an outer surface thereof, e.g., abrasive grit, cutting elements, and the like, for abrading occlusive material adjacent the distal tip. The abrasive material may be arranged in a predetermined pattern, e.g., an axial, circumferential, or helical pattern, to facilitate abrading occlusive material. The distal tip may have a substantially uniform diameter or tapered shape along its length.

公开(公告)号：US08123777B2

公开(公告)日：2012-02-28

申请号：US11241029

申请日：2005-09-30

申请人： Jeffrey Krolik ,  Amr Salahieh

发明人： Jeffrey Krolik ,  Amr Salahieh

IPC分类号： A61M29/00

CPC分类号： A61B17/22 ,  A61B17/221 ,  A61B2217/005 ,  A61F2/01

摘要： Apparatus and methods for aspirating emboli from a vascular filter or stent within a patient's circulatory system are provided. A filter sac of the vascular filter permits blood flow and captures emboli from the flow. The aspiration device removes emboli from within or proximal to the vascular filter or stent to reduce the risk to the ischemia during retrieval of the vascular filter and during a treatment procedure. Retrieval of the vascular filter may be accomplished using either the aspiration catheter or a separate retrieval catheter.

摘要翻译： 提供了用于从患者循环系统内的血管过滤器或支架吸出栓塞的装置和方法。 血管过滤器的过滤器允许血液流动并从流动中捕获栓塞。 抽吸装置从血管过滤器或支架内部或近侧移除栓塞，以减少在血管过滤器回收期间和治疗过程期间局部缺血的风险。 血管过滤器的检索可以使用抽吸导管或单独的取回导管来完成。

公开(公告)号：US20110172598A1

公开(公告)日：2011-07-14

申请号：US12966925

申请日：2010-12-13

申请人： Gregory Sampognaro ,  Gwendolyn Watanabe ,  Jeffrey Krolik

发明人： Gregory Sampognaro ,  Gwendolyn Watanabe ,  Jeffrey Krolik

IPC分类号： A61B17/22 ,  A61M25/10

CPC分类号： A61M25/1002 ,  A61B17/22 ,  A61B17/3207 ,  A61B2017/22001 ,  A61B2017/22038 ,  A61B2017/22069 ,  A61B2017/22094 ,  A61M25/0041 ,  A61M25/0068 ,  A61M25/008 ,  A61M25/0662 ,  A61M2025/0681 ,  A61M2025/1047 ,  A61M2025/1093

摘要： Apparatus and methods are provided for treating a lesion within a body lumen using a catheter including a balloon on its distal end and an abrasive distal tip extending distally beyond the balloon. The distal tip may terminate in a sharpened tip for penetrating occlusive material, e.g., a beveled tip, and includes abrasive material on an outer surface thereof, e.g., abrasive grit, cutting elements, and the like, for abrading occlusive material adjacent the distal tip. The abrasive material may be arranged in a predetermined pattern, e.g., an axial, circumferential, or helical pattern, to facilitate abrading occlusive material. The distal tip may have a substantially uniform diameter or tapered shape along its length.

摘要翻译： 提供了一种装置和方法，用于使用包括其远端上的气囊的导管和在远端超过气囊延伸的磨料远侧末端来治疗体腔内的损伤。 远侧末端可以终止于尖锐的尖端，用于穿透封闭材料，例如倾斜尖端，并且在其外表面上包括研磨材料，例如磨料砂粒，切割元件等，用于研磨邻近远端的封闭材料 。 研磨材料可以以预定图案布置，例如轴向，圆周或螺旋图案，以便于研磨闭塞材料。 远侧末端可以沿其长度具有基本均匀的直径或锥形形状。

公开(公告)号：US20080239874A1

公开(公告)日：2008-10-02

申请号：US11495134

申请日：2006-07-28

申请人： Mathieu P. Kemp ,  Frederick Vosburgh ,  Jeffrey Krolik

发明人： Mathieu P. Kemp ,  Frederick Vosburgh ,  Jeffrey Krolik

IPC分类号： F41G7/22

CPC分类号： F41G7/228 ,  F41G7/2253 ,  F42B19/01 ,  G01S3/8022 ,  G01S3/8083 ,  G05D1/12

摘要： An unmanned underwater vehicle for use in water and with at least one acoustic signal source includes a vehicle body, a steering mechanism to direct the vehicle body through the water, a propulsion device to force the vehicle body through the water, and an adaptive Doppler guidance and control (ADGC) system. The ADGC system is configured to receive acoustic signals from the at least one acoustic signal source and to control the steering mechanism using changes in at least one frequency component of the received acoustic signals caused by Doppler shifts.

摘要翻译： 一种用于水中并具有至少一个声信号源的无人水下航行器包括车体，用于引导车体通过水的转向机构，用于迫使车体通过水的推进装置，以及适应性多普勒引导 和控制（ADGC）系统。 ADGC系统被配置为从至少一个声信号源接收声信号，并且使用由多普勒频移引起的所接收的声信号的至少一个频率分量的变化来控制转向机构。

公开(公告)号：US20140039598A1

公开(公告)日：2014-02-06

申请号：US13954806

申请日：2013-07-30

申请人： Gregory C. Sampognaro ,  Stephen R. Ramee ,  Gwendolyn A. Watanabe ,  Jeffrey Krolik

发明人： Gregory C. Sampognaro ,  Stephen R. Ramee ,  Gwendolyn A. Watanabe ,  Jeffrey Krolik

IPC分类号： A61F2/958

CPC分类号： A61F2/958 ,  A61B17/1204 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/12122 ,  A61B17/12136 ,  A61B2017/00575 ,  A61B2017/00663 ,  A61B2017/00668 ,  A61F2/95 ,  A61F2002/9528

摘要： Generally described here are systems and methods for controlling bleeding. The systems generally comprise a blood control catheter having an expandable member, an intra-vessel support delivery device, and an intra-vessel support releasably attached to the intra-vessel support delivery device. The system may also include a guidewire. In some variations, the guidewire may be moveable between a tracking configuration and a delivery configuration.

摘要翻译： 这里通常描述了用于控制出血的系统和方法。 系统通常包括具有可扩张构件的血液控制导管，容器内支撑输送装置和可释放地附接到血管内支撑输送装置的血管内支架。 该系统还可以包括导丝。 在一些变型中，导丝可以在跟踪配置和传送配置之间移动。

公开(公告)号：US20070067011A1

公开(公告)日：2007-03-22

申请号：US11466442

申请日：2006-08-22

申请人： Jeffrey Krolik ,  Eliot Kim ,  James Dreher ,  Farhad Khosravi

发明人： Jeffrey Krolik ,  Eliot Kim ,  James Dreher ,  Farhad Khosravi

IPC分类号： A61F2/84 ,  A61F2/90

CPC分类号： A61F2/958 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/821 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0018 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61M25/1002

摘要： A stent includes a first portion including first and second bands of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second portion connected to the first portion by flexible connectors. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium and the second portion within a branch vessel extending from the ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.

摘要翻译： 支架包括第一部分，第一部分包括第一和第二细胞带，当支架从收缩状态扩展到扩张状态时向外张开，第二部分通过柔性连接器连接到第一部分。 在使用期间，将支架以收缩状态引入主容器中，并且将第一部分定位成邻近口，第二部分位于从口部延伸的分支容器中。 第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。 支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

公开(公告)号：US20070173918A1

公开(公告)日：2007-07-26

申请号：US11537569

申请日：2006-09-29

申请人： James Dreher ,  Amr Salahieh ,  Jeffrey Krolik

发明人： James Dreher ,  Amr Salahieh ,  Jeffrey Krolik

IPC分类号： A61F2/06

CPC分类号： A61F2/958 ,  A61F2002/821 ,  A61F2250/0039

摘要： Apparatus and methods for locating an ostium of a branch vessel include a delivery catheter having a distal end sized for introduction into the branch, and locator elements including first ends fixed to the distal end and second ends free from the distal ends. The locator elements are compressible from a transverse, deployed condition to an axial, contracted condition, wherein the second ends are disposed proximal to the first ends. During use, the catheter is directed through a guide catheter into the ostium with the locator elements compressed, and the locator elements are deployed within the branch in the contracted condition. The catheter is partially withdrawn from the branch, the locator elements resiliently expanding towards the deployed condition as they enter the main vessel. The catheter may be used to deliver a stent into the branch with the expanded locator elements facilitating positioning the stent.

摘要翻译： 用于定位分支容器的口的装置和方法包括具有尺寸适于引入分支的远端的输送导管，以及包括固定到远端的第一端和没有远端的第二端的定位器元件。 定位元件从横向展开状态可压缩到轴向收缩状态，其中第二端靠近第一端设置。 在使用期间，将导管引导通过引导导管进入口中，定位器元件被压缩，并且定位器元件在收缩状态下部署在分支内。 导管部分地从分支中取出，定位元件在进入主容器时朝展开状态弹性膨胀。 导管可用于将支架输送到分支中，扩张的定位器元件便于​​定位支架。

公开(公告)号：US07495999B2

公开(公告)日：2009-02-24

申请号：US11495134

申请日：2006-07-28

申请人： Mathieu P. Kemp ,  Frederick Vosburgh ,  Jeffrey Krolik

发明人： Mathieu P. Kemp ,  Frederick Vosburgh ,  Jeffrey Krolik

IPC分类号： F41G7/22

CPC分类号： F41G7/228 ,  F41G7/2253 ,  F42B19/01 ,  G01S3/8022 ,  G01S3/8083 ,  G05D1/12

摘要： An unmanned underwater vehicle for use in water and with at least one acoustic signal source includes a vehicle body, a steering mechanism to direct the vehicle body through the water, a propulsion device to force the vehicle body through the water, and an adaptive Doppler guidance and control (ADGC) system. The ADGC system is configured to receive acoustic signals from the at least one acoustic signal source and to control the steering mechanism using changes in at least one frequency component of the received acoustic signals caused by Doppler shifts.

摘要翻译： 一种用于水中并具有至少一个声信号源的无人水下航行器包括车体，用于引导车体通过水的转向机构，用于迫使车体通过水的推进装置，以及适应性多普勒引导 和控制（ADGC）系统。 ADGC系统被配置为从至少一个声信号源接收声信号，并且使用由多普勒频移引起的所接收的声信号的至少一个频率分量中的变化来控制转向机构。