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    STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELIVERING THEM
    1.
    发明申请
    STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELIVERING THEM 有权
    STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELMER THEM

    公开(公告)号：US20070073376A1

    公开(公告)日：2007-03-29

    申请号：US11466445

    申请日：2006-08-22

    申请人： Jeffrey Krolik ,  Eliot Kim ,  James Dreher ,  Farhad Khosravi

    发明人： Jeffrey Krolik ,  Eliot Kim ,  James Dreher ,  Farhad Khosravi

    IPC分类号： A61F2/84 ,  A61F2/90

    CPC分类号： A61F2/958 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/821 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0018 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61M25/1002

    摘要： A stent includes a first flaring portion including first and second sets of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second main portion connected to the first flaring portion. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The second portion resists expansion when the first portion is flared. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.

    摘要翻译： 支架包括第一扩张部分，其包括当支架从收缩状态扩张到扩张状态时向外张开的第一组和第二组细胞，以及连接到第一扩张部分的第二主要部分。 在使用期间，支架在收缩状态下被引入主容器中，并且将第一部分定位成邻近口。 第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。 当第一部分展开时，第二部分抵抗扩张。 支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

    STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELIVERING THEM
    2.
    发明申请
    STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELIVERING THEM 有权
    STEEP-TAPER FLARED STENTS AND APPARATUS AND METHODS FOR DELMER THEM

    公开(公告)号：US20070067011A1

    公开(公告)日：2007-03-22

    申请号：US11466442

    申请日：2006-08-22

    申请人： Jeffrey Krolik ,  Eliot Kim ,  James Dreher ,  Farhad Khosravi

    发明人： Jeffrey Krolik ,  Eliot Kim ,  James Dreher ,  Farhad Khosravi

    IPC分类号： A61F2/84 ,  A61F2/90

    CPC分类号： A61F2/958 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/821 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0018 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61M25/1002

    摘要： A stent includes a first portion including first and second bands of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second portion connected to the first portion by flexible connectors. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium and the second portion within a branch vessel extending from the ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.

    摘要翻译： 支架包括第一部分，第一部分包括第一和第二细胞带，当支架从收缩状态扩展到扩张状态时向外张开，第二部分通过柔性连接器连接到第一部分。 在使用期间，将支架以收缩状态引入主容器中，并且将第一部分定位成邻近口，第二部分位于从口部延伸的分支容器中。 第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。 支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

    Steep-taper flared stents and apparatus and methods for delivering them
    3.
    发明授权
    Steep-taper flared stents and apparatus and methods for delivering them 有权
    陡锥形支架，用于传递它们的装置和方法

    公开(公告)号：US08702777B2

    公开(公告)日：2014-04-22

    申请号：US11466445

    申请日：2006-08-22

    申请人： Jeffrey A. Krolik ,  Eliot Kim ,  James H. Dreher ,  Farhad Khosravi

    发明人： Jeffrey A. Krolik ,  Eliot Kim ,  James H. Dreher ,  Farhad Khosravi

    IPC分类号： A61F2/06

    CPC分类号： A61F2/958 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/821 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0018 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61M25/1002

    摘要： A stent includes a first flaring portion including first and second sets of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second main portion connected to the first flaring portion. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The second portion resists expansion when the first portion is flared. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.

    摘要翻译： 支架包括第一扩张部分，其包括当支架从收缩状态扩张到扩张状态时向外张开的第一组和第二组细胞，以及连接到第一扩张部分的第二主要部分。 在使用期间，支架在收缩状态下被引入主容器中，并且将第一部分定位成邻近口。 第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。 当第一部分展开时，第二部分抵抗扩张。 支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

    MATERIALS FORMABLE IN SITU WITHIN A MEDICAL DEVICE
    5.
    发明申请
    MATERIALS FORMABLE IN SITU WITHIN A MEDICAL DEVICE 有权
    在医疗设备中的原材料

    公开(公告)号：US20110092613A1

    公开(公告)日：2011-04-21

    申请号：US12970515

    申请日：2010-12-16

    申请人： Farhad Khosravi ,  James Dreher

    发明人： Farhad Khosravi ,  James Dreher

    IPC分类号： C08L33/08

    CPC分类号： A61L24/046 ,  A61F2/07 ,  Y10S623/926 ,  C08L71/02

    摘要： Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the polymer precursor undergo covalent bonding in situ to form a solid and nonbiodegradable material having a swellability less than about 20% v/v and a Young's modulus of at least about 100 kPa within about 30 seconds to about 30 minutes of initiating a chemical reaction of the functional groups to form the solid material.

    摘要翻译： 本发明的某些实施方案包括通过向患者内的空间引入溶解在可流动的水溶液中的至少约10,000分子量的水溶性聚合物前体形成材料。 聚合物前体上的官能团原位进行共价键合以形成具有小于约20％v / v的溶胀性和至少约100kPa的杨氏模量的固体和不可生物降解的材料，在约30秒至约30分钟内引发 官能团化学反应形成固体物质。

    Steep-taper flared stents and apparatus and methods for delivering them
    6.
    发明授权
    Steep-taper flared stents and apparatus and methods for delivering them 有权
    陡锥形支架，用于传递它们的装置和方法

    公开(公告)号：US07582111B2

    公开(公告)日：2009-09-01

    申请号：US11466442

    申请日：2006-08-22

    申请人： Jeffrey A. Krolik ,  Eliot Kim ,  James H. Dreher ,  Farhad Khosravi

    发明人： Jeffrey A. Krolik ,  Eliot Kim ,  James H. Dreher ,  Farhad Khosravi

    IPC分类号： A61F2/06

    CPC分类号： A61F2/958 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/821 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0018 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61M25/1002

    摘要： A stent includes a first portion including first and second bands of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second portion connected to the first portion by flexible connectors. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium and the second portion within a branch vessel extending from the ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.

    摘要翻译： 支架包括第一部分，第一部分包括第一和第二细胞带，当支架从收缩状态扩展到扩张状态时向外张开，第二部分通过柔性连接器连接到第一部分。 在使用期间，将支架以收缩状态引入主容器中，并且将第一部分定位成邻近口，第二部分位于从口部延伸的分支容器中。 第一部分是喇叭形的，导致第一组细胞的第一支柱从轴向向径向和部分圆周取向移动，并使得第二组细胞的第二支柱从轴向向径向移动。 支架进一步膨胀，使得第二部分在分支体腔内扩张，并且第一和第二支柱向着更圆周方向移动。

    Materials formable in situ within a medical device
    7.
    发明授权
    Materials formable in situ within a medical device 有权
    在医疗器械内原位成型的材料

    公开(公告)号：US07872068B2

    公开(公告)日：2011-01-18

    申请号：US11443504

    申请日：2006-05-30

    申请人： Farhad Khosravi ,  James Dreher

    发明人： Farhad Khosravi ,  James Dreher

    IPC分类号： C08L33/06 ,  A61M29/04 ,  A61F2/02 ,  A61F2/94

    CPC分类号： A61L24/046 ,  A61F2/07 ,  Y10S623/926 ,  C08L71/02

    摘要： Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the polymer precursor undergo covalent bonding in situ to form a solid and nonbiodegradable material having a swellability less than about 20% v/v and a Young's modulus of at least about 100 kPa within about 30 seconds to about 30 minutes of initiating a chemical reaction of the functional groups to form the solid material.

    摘要翻译： 本发明的某些实施方案包括通过向患者内的空间引入溶解在可流动的水溶液中的至少约10,000分子量的水溶性聚合物前体形成材料。 聚合物前体上的官能团原位进行共价键合以形成具有小于约20％v / v的溶胀性和至少约100kPa的杨氏模量的固体和不可生物降解的材料，在约30秒至约30分钟内引发 官能团化学反应形成固体物质。

    Materials formable in situ within a medical device
    8.
    发明申请
    Materials formable in situ within a medical device 有权
    在医疗器械内原位成型的材料

    公开(公告)号：US20070282366A1

    公开(公告)日：2007-12-06

    申请号：US11443504

    申请日：2006-05-30

    申请人： Farhad Khosravi ,  James Dreher

    发明人： Farhad Khosravi ,  James Dreher

    IPC分类号： A61M29/04 ,  A61F2/02 ,  A61F2/94

    CPC分类号： A61L24/046 ,  A61F2/07 ,  Y10S623/926 ,  C08L71/02

    摘要： Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the polymer precursor undergo covalent bonding in situ to form a solid and nonbiodegradable material having a swellability less than about 20% v/v and a Young's modulus of at least about 100 kPa within about 30 seconds to about 30 minutes of initiating a chemical reaction of the functional groups to form the solid material.

    摘要翻译： 本发明的某些实施方案包括通过向患者内的空间引入溶解在可流动的水溶液中的至少约10,000分子量的水溶性聚合物前体形成材料。 聚合物前体上的官能团原位进行共价键合以形成具有小于约20％v / v的溶胀性和至少约100kPa的杨氏模量的固体和不可生物降解的材料，在约30秒至约30分钟内引发 官能团化学反应形成固体物质。

    Balloon catheters and methods for use
    9.
    发明授权
    Balloon catheters and methods for use 有权
    气球导管及使用方法

    公开(公告)号：US09034025B2

    公开(公告)日：2015-05-19

    申请号：US13602074

    申请日：2012-08-31

    申请人： Archimedes Sanati ,  Farhad Khosravi

    发明人： Archimedes Sanati ,  Farhad Khosravi

    IPC分类号： A61F2/06 ,  A61F2/954 ,  A61F2/95

    CPC分类号： A61F2/954 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/30322 ,  A61F2002/821 ,  A61F2230/0071 ,  A61F2250/0018 ,  A61F2250/0026 ,  A61F2250/0039 ,  A61M25/1002 ,  A61M25/1011

    摘要： Apparatus and methods are provided for flaring a stent deployed within a branch vessel including an ostium communicating with a main vessel, a first end of the stent extending at least partially from the branch. A catheter is provided that includes a first balloon carried on its distal end, and a second balloon that includes a distal section overlying at least a portion of the first balloon and a proximal section. The catheter distal end is introduced into the main vessel and positioned through the ostium and stent into the branch until the first balloon is disposed within the stent. The first balloon is expanded to anchor the stent, and the second balloon is expanded to flare the first end of the stent. Optionally, the first balloon is expanded further, e.g., to expand the stent within the branch body lumen and/or dilate the lesion.

    摘要翻译： 提供了一种装置和方法，用于扩张部署在分支容器内的支架，该支架包括与主容器连通的口，所述支架的第一端至少部分地从所述分支延伸。 提供了一种导管，其包括在其远端承载的第一气囊，以及包括覆盖所述第一气囊的至少一部分的远端部分和近端部分的第二气囊。 将导管远端引入主容器中并定位成通过口和支架进入分支，直到第一气囊置于支架内。 将第一气囊扩张以锚固支架，并且将第二气囊膨胀以扩张支架的第一端。 任选地，第一气囊进一步膨胀，例如，以使分支体腔内的支架膨胀和/或扩张病变。