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    Method for detecting a progressive, chronic dementia disease, and corresponding peptides and detection reagents
    3.
    发明申请
    Method for detecting a progressive, chronic dementia disease, and corresponding peptides and detection reagents 审中-公开
    用于检测进行性慢性痴呆疾病的方法，以及相应的肽和检测试剂

    公开(公告)号：US20070031908A1

    公开(公告)日：2007-02-08

    申请号：US10549141

    申请日：2004-03-18

    申请人： Norbert Lamping ,  Hans Zucht ,  Hartmut Selle ,  Michael Jurgens ,  Gabriele Heine ,  Rudiger Hess ,  Markus Kellmann ,  Jens Lamerz ,  Thomas Mohring

    发明人： Norbert Lamping ,  Hans Zucht ,  Hartmut Selle ,  Michael Jurgens ,  Gabriele Heine ,  Rudiger Hess ,  Markus Kellmann ,  Jens Lamerz ,  Thomas Mohring

    IPC分类号： G01N33/543

    CPC分类号： C07K14/4711 ,  G01N33/6896 ,  G01N33/9406 ,  G01N2800/2821

    摘要： The invention relates to a method for detecting progressive, chronic dementia diseases or a predisposition to such diseases or method for the prognosis of such diseases. For this purpose, the concentration of particular peptides in body fluids or other samples from the patient is measured in a method which can be carried out in a laboratory. The invention further relates to peptides which have been found for determining the presence and/or the grade of the progressive, chronic dementia disease. The invention additionally relates to detection reagents such as antibodies and nucleic acids and the like for detecting said peptides or the corresponding nucleic acids. The invention further relates to pharmaceutical products which comprise the peptides according to the present invention, antibodies directed to said peptides, nucleic acids corresponding to said peptides, peptide antagonists, or peptide agonists for the therapy, diagnosis, prognosis or prophylaxis of neurological diseases, in particular of Alzheimer's disease. The invention further relates to methods for stratifying patients or participants in clinical studies.

    摘要翻译： 本发明涉及一种用于检测进行性慢性痴呆疾病或倾向于这些疾病或这种疾病预后的方法。 为此目的，以可以在实验室中进行的方法测量体液或来自患者的其它样品中特定肽的浓度。 本发明还涉及已经发现用于确定进行性慢性痴呆疾病的存在和/或等级的肽。 本发明还涉及用于检测所述肽或相应核酸的检测试剂，例如抗体和核酸等。 本发明还涉及包含根据本发明的肽的药物产品，针对所述肽的抗体，对应于所述肽的核酸，肽拮抗剂或肽激动剂，用于治疗，诊断，预后或预防神经疾病， 特别是阿尔茨海默病。 本发明还涉及用于分层临床研究中的患者或参与者的方法。