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公开(公告)号：US09950096B2
公开(公告)日：2018-04-24
申请号：US13005528
申请日：2011-01-12
申请人： Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page
发明人： Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page
CPC分类号： A61L27/46 , A61L27/446 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/406 , C08L75/04
摘要： The present invention encompasses the finding that certain treatments (e.g., surface modifications) to particulate materials can provide surprising and unexpected benefits and/or features to composites and/or compositions as described herein. In some embodiments, such benefits and/or features may render particular composites and/or compositions particularly useful in a certain therapeutic context (e.g, for repair of tibial plateau, femoral head, craniofacial, or lateral mandibular body defects). The present invention demonstrates that certain composites and/or compositions wherein the particular material is or comprises defatted bone have surprising and beneficial attributes.
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公开(公告)号：US20100112032A1
公开(公告)日：2010-05-06
申请号：US12608850
申请日：2009-10-29
申请人： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
发明人： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
摘要： Present inventions present composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. A porous composite comprises a plurality of bone particles; and polyurethanes with which the bone particles are combined. To prepare a porous composite, a composition comprise a plurality of bone particles, polyurethane precursors including polyisocyanate prepolymers and polyols, water and catalyst. A composition is either naturally moldable and/or injectable, or it can be made moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
摘要翻译： 本发明提出了骨颗粒和聚氨酯的复合材料，以及制备这种复合材料及其用途的方法。 多孔复合材料包括多个骨颗粒; 和与其结合的聚氨酯。 为了制备多孔复合材料，组合物包含多个骨颗粒，包括多异氰酸酯预聚物和多元醇的聚氨酯前体，水和催化剂。 组合物可以是天然可模塑的和/或可注射的，或者它可以是可模制的和/或可注射的。 在植入或注射后，可以将组合物设置成形成提供机械强度并支持细胞生长的多孔复合材料。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为大多数矫形应用提供机械强度。
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公开(公告)号：US09333276B2
公开(公告)日：2016-05-10
申请号：US12608850
申请日：2009-10-29
申请人： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
发明人： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
摘要： Present inventions present composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. A porous composite comprises a plurality of bone particles; and polyurethanes with which the bone particles are combined. To prepare a porous composite, a composition comprise a plurality of bone particles, polyurethane precursors including polyisocyanate prepolymers and polyols, water and catalyst. A composition is either naturally moldable and/or injectable, or it can be made moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
摘要翻译： 本发明提出了骨颗粒和聚氨酯的复合材料，以及制备这种复合材料及其用途的方法。 多孔复合材料包括多个骨颗粒; 和与其结合的聚氨酯。 为了制备多孔复合材料，组合物包含多个骨颗粒，包括多异氰酸酯预聚物和多元醇的聚氨酯前体，水和催化剂。 组合物可以是天然可模塑的和/或可注射的，或者它可以是可模制的和/或可注射的。 在植入或注射后，可以将组合物设置成形成提供机械强度并支持细胞生长的多孔复合材料。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为大多数矫形应用提供机械强度。
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公开(公告)号：US20150283182A1
公开(公告)日：2015-10-08
申请号：US13280299
申请日：2011-10-24
CPC分类号： A61K35/32 , A61K38/1875 , A61K47/34 , A61L27/3608 , A61L27/44 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/414 , C08L75/04
摘要： Embodiments of the present inventions comprise composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. Certain embodiments further comprise a growth factor that can be provided in powder form. Growth factors may be bone morphogenic proteins, such as rhBMP-2. A porous composite comprises a plurality of bone particles, polyurethanes with which the bone particles are combined, and at least one growth factor. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
摘要翻译： 本发明的实施方案包括骨颗粒和聚氨酯的复合材料，以及制备这种复合材料及其用途的方法。 某些实施方案还包括可以以粉末形式提供的生长因子。 生长因子可能是骨形态发生蛋白，如rhBMP-2。 多孔复合材料包括多个骨颗粒，骨颗粒与其结合的聚氨酯和至少一个生长因子。 组合物可以是可模制的和/或可注射的。 在植入或注射后，可以将组合物设置成形成提供机械强度并支持细胞生长的多孔复合材料。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为大多数矫形应用提供机械强度。
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公开(公告)号：US20110237704A1
公开(公告)日：2011-09-29
申请号：US13005528
申请日：2011-01-12
申请人： Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page , Subhabrata Bhattacharyya
发明人： Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page , Subhabrata Bhattacharyya
CPC分类号： A61L27/46 , A61L27/446 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/406 , C08L75/04
摘要： The present invention encompasses the finding that certain treatments (e.g., surface modifications) to particulate materials can provide surprising and unexpected benefits and/or features to composites and/or compositions as described herein. In some embodiments, such benefits and/or features may render particular composites and/or compositions particularly useful in a certain therapeutic context (e.g, for repair of tibial plateau, femoral head, craniofacial, or lateral mandibular body defects). The present invention demonstrates that certain composites and/or compositions wherein the particular material is or comprises defatted bone have surprising and beneficial attributes.
摘要翻译： 本发明包括对颗粒材料的某些处理（例如，表面改性）可以为本文所述的复合材料和/或组合物提供令人惊奇和意想不到的益处和/或特征的发现。 在一些实施方案中，这样的益处和/或特征可以使特定的复合材料和/或组合物在特定的治疗背景下特别有用（例如，用于修复胫骨平台，股骨头，颅面或侧向下颌体缺陷）。 本发明证明特定材料是或包含脱脂骨的某些复合物和/或组合物具有令人惊奇和有益的属性。
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公开(公告)号：US20100297082A1
公开(公告)日：2010-11-25
申请号：US12783548
申请日：2010-05-19
IPC分类号： A61F2/28 , B29C43/02 , A61P19/00 , A61K48/00 , A61K35/12 , A61K38/18 , A61K38/02 , A61K38/43 , A61K31/195 , A61K47/34
CPC分类号： A61K35/32 , A61F2/28 , A61F2310/00359 , A61K31/00 , A61K31/195 , A61K38/00 , A61L27/3608 , A61L27/44 , B29C43/003 , C08L75/04
摘要： Present inventions present composites of particles and polymers, as well as methods of making such composite and uses thereof. A low or non-porous composite comprises a plurality of bone particles; and polyurethane components with which the bone particles are combined. Provided composites can be prepared in a one-shot process. Alternatively or additionally, composites can be prepared by compression molding under a high pressure. Before or after implantation, provided composites may be set to form a hardened state of composites that provides mechanical strength and supports the in-growth of cells.
摘要翻译： 本发明提出了颗粒和聚合物的复合材料，以及制备这种复合材料及其用途的方法。 低或非多孔复合材料包括多个骨颗粒; 和与其组合的聚氨酯组分。 提供的复合材料可以在一个单一的过程中制备。 或者或另外，复合材料可以通过在高压下压塑而制备。 在植入之前或之后，提供的复合材料可以被设置成形成复合材料的硬化状态，其提供机械强度并支持细胞的生长。
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