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公开(公告)号：US20140228365A1
公开(公告)日：2014-08-14
申请号：US14175751
申请日：2014-02-07
申请人： Anna QUATTROPANI , Thomas Rueckle , Matthias Schwarz , Jerome Dorbais , Wolfgang Sauer , Christophe Cleva , Gwenaelle Desforges
发明人： Anna QUATTROPANI , Thomas Rueckle , Matthias Schwarz , Jerome Dorbais , Wolfgang Sauer , Christophe Cleva , Gwenaelle Desforges
IPC分类号： C07D417/04 , C07D417/14
CPC分类号： C07D417/04 , C07D277/46 , C07D417/14
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neturodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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公开(公告)号：US20130274241A1
公开(公告)日：2013-10-17
申请号：US13995803
申请日：2011-12-16
申请人： Catherine Jorand-Lebrun , Stefano Crosignani , Jerome Dorbais , Tania Grippi-Vallotton , Adeline Pretre
发明人： Catherine Jorand-Lebrun , Stefano Crosignani , Jerome Dorbais , Tania Grippi-Vallotton , Adeline Pretre
IPC分类号： C07D403/04 , C07D401/14 , A61K31/551 , C07D403/14 , A61K31/4192 , A61K31/5377 , A61K31/454
CPC分类号： C07D403/04 , A61K31/4192 , A61K31/454 , A61K31/537 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , Y02A50/414
摘要： Compounds of Formula (I) are used for the treatment of inflammation and autoimmune disorders.
摘要翻译： 式（I）的化合物用于治疗炎症和自身免疫性疾病。
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3.发明申请5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS 有权5-（联苯-4-基）-3-苯基-1,2,4-氧杂二唑衍生物作为配位体1-磷酸酯（SIP）受体的配体公开(公告)号：US20130116289A1
公开(公告)日：2013-05-09
申请号：US13809013
申请日：2011-07-06
申请人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
发明人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
IPC分类号： A61K31/4245 , C07D271/12 , A61K31/70
CPC分类号： C07D271/06 , A61K31/4245
摘要： The present invention provides compounds of Formula (I), as selective S1P1 inhibitors, as well as their use for treating multiple sclerosis and other diseases.
摘要翻译： 本发明提供作为选择性S1P1抑制剂的式（I）化合物及其用于治疗多发性硬化症和其它疾病的用途。
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公开(公告)号：US20110306636A1
公开(公告)日：2011-12-15
申请号：US13203044
申请日：2010-03-02
申请人： Anna Quattropani , Patrick Gerber , Jerome Dorbais
发明人： Anna Quattropani , Patrick Gerber , Jerome Dorbais
IPC分类号： A61K31/444 , A61K31/4439 , A61P3/10 , A61P11/06 , A61P37/06 , A61P17/00 , A61P19/02 , C07D413/04 , A61P1/00
CPC分类号： C07D413/04 , A61K9/0019 , A61K9/0095 , A61K9/2063 , A61K9/4866 , A61K47/02 , C07D413/14
摘要： The present invention provides oxadiazole pyridine derivatives of Formula (I), their use as medicaments and their use for treating multiple sclerosis and other diseases.
摘要翻译： 本发明提供式（I）的恶二唑吡啶衍生物，其用作药物及其用于治疗多发性硬化症和其它疾病的用途。
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公开(公告)号：US07799814B2
公开(公告)日：2010-09-21
申请号：US11915476
申请日：2006-05-24
IPC分类号： A61K31/425 , C07D277/00
CPC分类号： C07D277/46 , C07D277/48 , C07D277/56 , C07D417/14 , C07D491/10 , C07D493/08
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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6.发明授权公开(公告)号：US08058289B2
公开(公告)日：2011-11-15
申请号：US12906729
申请日：2010-10-18
申请人： Thomas Rueckle , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
发明人： Thomas Rueckle , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
IPC分类号： A61K31/4355 , C07D471/04 , A61P29/00 , A61P9/00 , A61P25/28 , A61P31/04 , A61P31/12 , A61P27/14 , A61P37/08 , A61P37/06 , A61P1/18 , A61P1/16 , A61P7/02 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention is related to pyridine methylene azolidinone derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的吡啶亚甲基唑烷酮衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集， 癌症，移植，移植排斥或肺部损伤。
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公开(公告)号：US20110086843A1
公开(公告)日：2011-04-14
申请号：US12952231
申请日：2010-11-23
IPC分类号： A61K31/553 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/41 , A61P29/00 , A61P31/00 , A61P11/06 , A61P9/00 , A61P25/00 , A61P35/00 , A61P13/12 , A61P37/06
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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公开(公告)号：US07879888B2
公开(公告)日：2011-02-01
申请号：US11915521
申请日：2006-05-24
IPC分类号： A61K31/426 , A61K31/5377 , C07D277/20 , C07D413/14
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
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公开(公告)号：US20090029998A1
公开(公告)日：2009-01-29
申请号：US10585635
申请日：2005-01-11
申请人： Anna Quattropani , Thomas Rueckle , Matthias Schwarz , Jerome Dorbais , Wolfgang Sauer , Christophe Cleva , Gwenaelle Desforges
发明人： Anna Quattropani , Thomas Rueckle , Matthias Schwarz , Jerome Dorbais , Wolfgang Sauer , Christophe Cleva , Gwenaelle Desforges
IPC分类号： A61K31/427 , C07D277/38 , C07D401/04 , A61K31/5377 , A61P29/00 , A61P25/28 , A61P9/00 , A61P31/12 , A61P37/00 , A61K31/454 , C07D413/04
CPC分类号： C07D417/04 , C07D277/46 , C07D417/14
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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公开(公告)号：US20080188531A1
公开(公告)日：2008-08-07
申请号：US11915476
申请日：2006-05-24
IPC分类号： A61K31/427 , C07D417/04 , A61P25/28 , A61P25/00 , A61P9/00
CPC分类号： C07D277/46 , C07D277/48 , C07D277/56 , C07D417/14 , C07D491/10 , C07D493/08
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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