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公开(公告)号：US20110306636A1
公开(公告)日：2011-12-15
申请号：US13203044
申请日：2010-03-02
申请人： Anna Quattropani , Patrick Gerber , Jerome Dorbais
发明人： Anna Quattropani , Patrick Gerber , Jerome Dorbais
IPC分类号： A61K31/444 , A61K31/4439 , A61P3/10 , A61P11/06 , A61P37/06 , A61P17/00 , A61P19/02 , C07D413/04 , A61P1/00
CPC分类号： C07D413/04 , A61K9/0019 , A61K9/0095 , A61K9/2063 , A61K9/4866 , A61K47/02 , C07D413/14
摘要： The present invention provides oxadiazole pyridine derivatives of Formula (I), their use as medicaments and their use for treating multiple sclerosis and other diseases.
摘要翻译： 本发明提供式（I）的恶二唑吡啶衍生物，其用作药物及其用于治疗多发性硬化症和其它疾病的用途。
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公开(公告)号：US20100240658A1
公开(公告)日：2010-09-23
申请号：US12675235
申请日：2008-10-01
申请人： Anna Quattropani , Cyril Montagne , Wolfgang Sauer , Stefano Crosignani , Agnes Bombrun , Mathilde Muzerelle , Jerome Dorbais , Delphine Marin , Jerome Gonzalez , Patrick Gerber
发明人： Anna Quattropani , Cyril Montagne , Wolfgang Sauer , Stefano Crosignani , Agnes Bombrun , Mathilde Muzerelle , Jerome Dorbais , Delphine Marin , Jerome Gonzalez , Patrick Gerber
IPC分类号： A61K31/5377 , C07D271/06 , C07D413/02 , A61K31/4245 , A61K31/4439 , A61K31/454
CPC分类号： C07D263/32 , C07D413/04 , C07D413/10
摘要： The invention relates to compounds of formula I: wherein R1, R2, Ra, Rb, W, Q and S have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，Ra，Rb，W，Q和S具有权利要求16中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US08791142B2
公开(公告)日：2014-07-29
申请号：US13203044
申请日：2010-03-02
申请人： Anna Quattropani , Patrick Gerber , Jerome Dorbais
发明人： Anna Quattropani , Patrick Gerber , Jerome Dorbais
IPC分类号： A61K31/443 , C07D413/04
CPC分类号： C07D413/04 , A61K9/0019 , A61K9/0095 , A61K9/2063 , A61K9/4866 , A61K47/02 , C07D413/14
摘要： The present invention provides oxadiazole pyridine derivatives of Formula (I), their use as medicaments and their use for treating multiple sclerosis and other diseases.
摘要翻译： 本发明提供式（I）的恶二唑吡啶衍生物，其用作药物及其用于治疗多发性硬化症和其它疾病的用途。
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公开(公告)号：US20140228365A1
公开(公告)日：2014-08-14
申请号：US14175751
申请日：2014-02-07
申请人： Anna QUATTROPANI , Thomas Rueckle , Matthias Schwarz , Jerome Dorbais , Wolfgang Sauer , Christophe Cleva , Gwenaelle Desforges
发明人： Anna QUATTROPANI , Thomas Rueckle , Matthias Schwarz , Jerome Dorbais , Wolfgang Sauer , Christophe Cleva , Gwenaelle Desforges
IPC分类号： C07D417/04 , C07D417/14
CPC分类号： C07D417/04 , C07D277/46 , C07D417/14
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neturodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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5.发明申请5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS 有权5-（联苯-4-基）-3-苯基-1,2,4-氧杂二唑衍生物作为配位体1-磷酸酯（SIP）受体的配体公开(公告)号：US20130116289A1
公开(公告)日：2013-05-09
申请号：US13809013
申请日：2011-07-06
申请人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
发明人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
IPC分类号： A61K31/4245 , C07D271/12 , A61K31/70
CPC分类号： C07D271/06 , A61K31/4245
摘要： The present invention provides compounds of Formula (I), as selective S1P1 inhibitors, as well as their use for treating multiple sclerosis and other diseases.
摘要翻译： 本发明提供作为选择性S1P1抑制剂的式（I）化合物及其用于治疗多发性硬化症和其它疾病的用途。
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公开(公告)号：US07799814B2
公开(公告)日：2010-09-21
申请号：US11915476
申请日：2006-05-24
IPC分类号： A61K31/425 , C07D277/00
CPC分类号： C07D277/46 , C07D277/48 , C07D277/56 , C07D417/14 , C07D491/10 , C07D493/08
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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7.发明授权5-(biphenyl-4-yl)-3-phenyl-1,2,4-oxadiazolyl derivatives as ligands on the sphingosine 1-phosphate(SIP)receptors 有权5-（联苯-4-基）-3-苯基-1,2,4-恶二唑基衍生物作为鞘氨醇1-磷酸（SIP）受体上的配体公开(公告)号：US09029405B2
公开(公告)日：2015-05-12
申请号：US13809013
申请日：2011-07-06
申请人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
发明人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D271/06 , A61K31/4245
摘要： The present invention provides compounds of Formula (I), as selective S1P1 inhibitors, as well as their use for treating multiple sclerosis and other diseases.
摘要翻译： 本发明提供作为选择性S1P1抑制剂的式（I）化合物及其用于治疗多发性硬化症和其它疾病的用途。
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8.发明申请公开(公告)号：US20080269227A1
公开(公告)日：2008-10-30
申请号：US11574613
申请日：2005-09-02
申请人： Thomas Rueckle , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
发明人： Thomas Rueckle , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
IPC分类号： A61K31/519 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/00 , A61P31/00 , A61K31/4439 , A61K31/4355 , A61P35/00 , C07D471/04 , C07D491/048 , A61K31/4985
CPC分类号： C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention is related to fused pyridine methylene azolidinone derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的稠合吡啶亚甲基唑烷酮衍生物，特别是用于治疗和/或预防自身免疫性疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集 ，癌症，移植，移植排斥或肺部损伤。
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公开(公告)号：US20080221180A1
公开(公告)日：2008-09-11
申请号：US11915521
申请日：2006-05-24
IPC分类号： A61K31/427 , C07D417/04 , A61P25/00 , A61P31/00 , A61P37/00
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
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公开(公告)号：US20060004020A1
公开(公告)日：2006-01-05
申请号：US10518543
申请日：2003-07-04
申请人： Catherine Jorand-Lebrun , Jerome Dorbais , Anna Quattropani , Matthias Schwarz , Delphine Valognes
发明人： Catherine Jorand-Lebrun , Jerome Dorbais , Anna Quattropani , Matthias Schwarz , Delphine Valognes
IPC分类号： A61K31/496 , A61K31/4025 , A61K31/416 , A61K31/401 , C07D43/02 , C07D27/18
CPC分类号： C07D231/12 , C07D207/22 , C07D233/56 , C07D249/08 , C07D403/06
摘要： The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R1 is selected from the group comprising or consisting of H and C1-C6-alkyl, for the prevention and/or treatment of preterm labor, premature birth or dysmenorrhea.
摘要翻译： 本发明涉及式（I）的新型吡咯烷衍生物，其几何异构体，其作为对映异构体的光学活性形式，非对映体，这些及其外消旋体形式的混合物，及其盐，其中R 1〜 选自由H和C 1 -C 6 - 烷基组成或由H和C 1 -C 6 - 烷基组成的组，用于预防和/或治疗早产，早产或痛经。
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