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公开(公告)号：US20140228365A1
公开(公告)日：2014-08-14
申请号：US14175751
申请日：2014-02-07
申请人： Anna QUATTROPANI , Thomas Rueckle , Matthias Schwarz , Jerome Dorbais , Wolfgang Sauer , Christophe Cleva , Gwenaelle Desforges
发明人： Anna QUATTROPANI , Thomas Rueckle , Matthias Schwarz , Jerome Dorbais , Wolfgang Sauer , Christophe Cleva , Gwenaelle Desforges
IPC分类号： C07D417/04 , C07D417/14
CPC分类号： C07D417/04 , C07D277/46 , C07D417/14
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neturodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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2.发明申请5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS 有权5-（联苯-4-基）-3-苯基-1,2,4-氧杂二唑衍生物作为配位体1-磷酸酯（SIP）受体的配体公开(公告)号：US20130116289A1
公开(公告)日：2013-05-09
申请号：US13809013
申请日：2011-07-06
申请人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
发明人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
IPC分类号： A61K31/4245 , C07D271/12 , A61K31/70
CPC分类号： C07D271/06 , A61K31/4245
摘要： The present invention provides compounds of Formula (I), as selective S1P1 inhibitors, as well as their use for treating multiple sclerosis and other diseases.
摘要翻译： 本发明提供作为选择性S1P1抑制剂的式（I）化合物及其用于治疗多发性硬化症和其它疾病的用途。
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公开(公告)号：US20120115869A1
公开(公告)日：2012-05-10
申请号：US13383848
申请日：2010-07-14
IPC分类号： A61K31/41 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D401/12 , A61K31/4439 , A61K31/4709 , A61K31/5377 , A61P37/08 , A61P11/06 , A61P27/02 , A61P27/00 , A61K31/422 , A61K31/428 , A61K31/4245 , A61K31/427 , A61K31/4155 , A61P17/00 , A61P29/00 , C07D257/04
CPC分类号： C07D257/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula (I) for use as pharmaceutical active compounds, as well as pharmaceutical formulations containing the same, for the treatment of allergic diseases.
摘要翻译： 本发明涉及用作药物活性化合物的式（I）化合物，以及含有该化合物的用于治疗过敏性疾病的药物制剂。
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公开(公告)号：US20120022109A1
公开(公告)日：2012-01-26
申请号：US13260779
申请日：2010-03-29
IPC分类号： A61K31/4245 , C07D413/10 , A61K31/454 , A61P37/00 , A61P1/16 , A61P19/02 , A61P29/00 , A61P25/00 , A61P9/10 , C07D271/06 , A61P1/00
CPC分类号： A61K31/4245 , A61K31/192 , A61K31/197 , C07C57/30 , C07D271/06
摘要： The invention relates to oxadiazole compounds of formula I. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式I的恶二唑化合物。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US20110312960A1
公开(公告)日：2011-12-22
申请号：US13222072
申请日：2011-08-31
申请人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
发明人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
IPC分类号： A61K31/498 , C07D413/14 , C07D471/04 , A61K31/5377 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/28 , A61P31/04 , A61P31/12 , A61P37/08 , A61P11/06 , A61P1/18 , A61P13/12 , A61P7/02 , A61P35/00 , A61P37/06 , A61P15/08 , A61P7/00 , A61P11/00 , A61P17/06 , A61P19/04 , A61P1/00 , A61P25/00 , A61P25/14 , A61P9/10 , A61P9/08 , A61P21/00 , A61P35/04 , C07D241/44
CPC分类号： C07D241/44 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
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公开(公告)号：US20110306636A1
公开(公告)日：2011-12-15
申请号：US13203044
申请日：2010-03-02
申请人： Anna Quattropani , Patrick Gerber , Jerome Dorbais
发明人： Anna Quattropani , Patrick Gerber , Jerome Dorbais
IPC分类号： A61K31/444 , A61K31/4439 , A61P3/10 , A61P11/06 , A61P37/06 , A61P17/00 , A61P19/02 , C07D413/04 , A61P1/00
CPC分类号： C07D413/04 , A61K9/0019 , A61K9/0095 , A61K9/2063 , A61K9/4866 , A61K47/02 , C07D413/14
摘要： The present invention provides oxadiazole pyridine derivatives of Formula (I), their use as medicaments and their use for treating multiple sclerosis and other diseases.
摘要翻译： 本发明提供式（I）的恶二唑吡啶衍生物，其用作药物及其用于治疗多发性硬化症和其它疾病的用途。
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公开(公告)号：US07799814B2
公开(公告)日：2010-09-21
申请号：US11915476
申请日：2006-05-24
IPC分类号： A61K31/425 , C07D277/00
CPC分类号： C07D277/46 , C07D277/48 , C07D277/56 , C07D417/14 , C07D491/10 , C07D493/08
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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![2-MORPHOLINO-PYRIDO[3,2-D]PYRIMIDINES](/abs-image/US/2011/12/01/US20110293564A1/abs.jpg.150x150.jpg)
公开(公告)号：US20110293564A1
公开(公告)日：2011-12-01
申请号：US13147449
申请日：2010-02-04
IPC分类号： A61K38/21 , A61K31/5377 , A61P25/00 , A61P35/00 , A61P37/00 , A61P19/04 , A61P29/00 , A61P1/00 , A61P17/06 , A61P17/00 , A61P37/06 , A61P5/14 , A61P21/04 , A61P27/02 , A61P7/06 , A61P35/02 , A61P9/10 , A61P9/00 , A61P35/04 , A61P31/14 , A61P1/16 , A61P25/16 , A61K39/395 , C07D413/14
CPC分类号： C07D471/04
摘要： This invention relates to compounds of Formula (I) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other deseases like cancers.
摘要翻译： 本发明涉及作为用于治疗自身免疫疾病，炎症性疾病，多发性硬化和其它疾病如癌症的Pi3k抑制剂的式（I）化合物。
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9.发明授权公开(公告)号：US08058289B2
公开(公告)日：2011-11-15
申请号：US12906729
申请日：2010-10-18
申请人： Thomas Rueckle , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
发明人： Thomas Rueckle , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
IPC分类号： A61K31/4355 , C07D471/04 , A61P29/00 , A61P9/00 , A61P25/28 , A61P31/04 , A61P31/12 , A61P27/14 , A61P37/08 , A61P37/06 , A61P1/18 , A61P1/16 , A61P7/02 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention is related to pyridine methylene azolidinone derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的吡啶亚甲基唑烷酮衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集， 癌症，移植，移植排斥或肺部损伤。
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公开(公告)号：US20110086843A1
公开(公告)日：2011-04-14
申请号：US12952231
申请日：2010-11-23
IPC分类号： A61K31/553 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/41 , A61P29/00 , A61P31/00 , A61P11/06 , A61P9/00 , A61P25/00 , A61P35/00 , A61P13/12 , A61P37/06
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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