Vaccines against vesicular stomatitis
    5.
    发明申请
    Vaccines against vesicular stomatitis 有权
    针对水泡性口炎的疫苗

    公开(公告)号:US20080124357A1

    公开(公告)日:2008-05-29

    申请号:US11505064

    申请日:2006-08-16

    摘要: The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against vesicular stomatitis virus (VSV) in an animal susceptible to VSV. The composition may include a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector may contain at least one heterologous nucleic acid molecule(s), expresses in vivo in the animal VSV antigen(s), immunogen(s) or epitope(s) thereof, e.g., VSV G protein and/or VSV N protein and/or VSV M protein. The heterologous nucleic acid molecule(s) may be adjusted to the vector/mammalian cell system by codon optimization. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated.

    摘要翻译: 本发明涉及一种免疫原性或疫苗组合物,以诱导针对VSV易感的动物中的水泡性口炎病毒(VSV)的免疫应答或保护性免疫应答。 组合物可以包括药学上或兽医学上可接受的载体或赋形剂和载体。 载体可以含有至少一种异源核酸分子,在体内表达动物VSV抗原,其免疫原或其表位,例如VSV G蛋白和/或VSV N蛋白,以及 /或VSV M蛋白。 可以通过密码子优化将异源核酸分子调整到载体/哺乳动物细胞系统。 组合物可以含有佐剂,如卡波姆。 还考虑制备和使用这种组合物的方法,包括初始 - 加强方案和包括鉴别诊断。

    Recombinant vaccine against bluetongue virus
    6.
    发明授权
    Recombinant vaccine against bluetongue virus 有权
    针对蓝舌病毒的重组疫苗

    公开(公告)号:US07862821B2

    公开(公告)日:2011-01-04

    申请号:US11444698

    申请日:2006-06-01

    摘要: The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against Orbiviruses, more specifically bluetongue virus (BTV) in an animal susceptible to BTV infection. The composition may include a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector may contain heterologous nucleic acid molecule(s), expresses in vivo in the animal BTV antigen, immunogen or epitope thereof, e.g., BTV VP2; BTV VP2 and VP5; BTV VP2 and VP5 and VP3 and/or VP7. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated. AGACAGTGGTCAATTCCAATGGTACTGTTTGACGATAC

    摘要翻译: 本发明涉及一种免疫原性或疫苗组合物,用于在易感BTV感染的动物中诱导针对罗非鱼病毒的免疫应答或保护性免疫应答,更具体地说是Bluetong病毒(BTV)。 组合物可以包括药学上或兽医学上可接受的载体或赋形剂和载体。 载体可以含有异源核酸分子,在体内在动物BTV抗原,免疫原或其表位例如BTV VP2中表达; BTV VP2和VP5; BTV VP2和VP5以及VP3和/或VP7。 组合物可以含有佐剂,如卡波姆。 还考虑制备和使用这种组合物的方法,包括初始 - 加强方案和包括鉴别诊断。 AGACAGTGGTCAATTCCAATGGTACTGTTTGACGATAC