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公开(公告)号:US20120114691A1
公开(公告)日:2012-05-10
申请号:US13357755
申请日:2012-01-25
申请人: Jules Maarten Minke , Jean-Christophe Audonnet , Alan John Guthrie , Nigel James Maclachlan , Jiansheng Yao
发明人: Jules Maarten Minke , Jean-Christophe Audonnet , Alan John Guthrie , Nigel James Maclachlan , Jiansheng Yao
CPC分类号: A61K39/15 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/86 , C12N2710/24043 , C12N2720/12122 , C12N2720/12134
摘要: The present invention provides vectors that contain and express in vivo the genes encoding VP2 and VP5 of African Horse Sickness Virus or an epitope thereof that elicits an immune response in a horse against African horse sickness virus, compositions comprising said vectors, methods of vaccination against African horse sickness virus, and kits for use with such methods and compositions.
摘要翻译: 本发明提供了在体内含有和表达编码非洲马疾病病毒VP2和VP5的基因或其在马中针对非洲马病病毒引起免疫应答的表位的载体,包含所述载体的组合物,针对非洲的疫苗接种方法 马病病毒,以及用于此类方法和组合物的试剂盒。
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公开(公告)号:US08168200B2
公开(公告)日:2012-05-01
申请号:US12604048
申请日:2009-10-22
申请人: Jules Maarten Minke , Jean-Christophe Audonnet , Alan John Guthrie , Nigel James MacLachlan , Jiansheng Yao
发明人: Jules Maarten Minke , Jean-Christophe Audonnet , Alan John Guthrie , Nigel James MacLachlan , Jiansheng Yao
IPC分类号: A61K39/15 , A61K39/295 , C12N15/85 , C12N15/863 , C12N5/10 , C12N7/01
CPC分类号: A61K39/15 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/86 , C12N2710/24043 , C12N2720/12122 , C12N2720/12134
摘要: The present invention provides vectors that contain and express in vivo the genes encoding VP2 and VP5 of African Horse Sickness Virus or an epitope thereof that elicits an immune response in a horse against African horse sickness virus, compositions comprising said vectors, methods of vaccination against African horse sickness virus, and kits for use with such methods and compositions.
摘要翻译: 本发明提供了在体内含有和表达编码非洲马疾病病毒VP2和VP5的基因或其在马中针对非洲马病病毒引起免疫应答的表位的载体,包含所述载体的组合物,针对非洲的疫苗接种方法 马病病毒,以及用于此类方法和组合物的试剂盒。
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公开(公告)号:US20070048821A1
公开(公告)日:2007-03-01
申请号:US11264622
申请日:2005-11-01
申请人: Jules Minke , Kemal Karaca , Jiansheng Yao
发明人: Jules Minke , Kemal Karaca , Jiansheng Yao
CPC分类号: A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/005 , C12N2710/24043 , C12N2760/16122 , C12N2760/16134
摘要: The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.
摘要翻译: 本发明包括流感疫苗,特别是犬流感疫苗。 疫苗可以是重组痘病毒疫苗或灭活疫苗。 本发明还包括编码和表达流感抗原,表位或免疫原的重组痘病毒载体,其可用于保护动物,特别是狗免受流感。
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公开(公告)号:US20080241184A1
公开(公告)日:2008-10-02
申请号:US12020656
申请日:2008-01-28
申请人: Jules Maarten Minke , Kemal Karaca , Jiansheng Yao
发明人: Jules Maarten Minke , Kemal Karaca , Jiansheng Yao
CPC分类号: A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/005 , C12N2710/24043 , C12N2760/16122 , C12N2760/16134
摘要: The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.
摘要翻译: 本发明包括流感疫苗,特别是犬流感疫苗。 疫苗可以是重组痘病毒疫苗或灭活疫苗。 本发明还包括编码和表达流感抗原,表位或免疫原的重组痘病毒载体,其可用于保护动物,特别是狗免受流感。
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公开(公告)号:US20080124357A1
公开(公告)日:2008-05-29
申请号:US11505064
申请日:2006-08-16
CPC分类号: A61K39/205 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C12N2710/24043 , C12N2760/20234
摘要: The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against vesicular stomatitis virus (VSV) in an animal susceptible to VSV. The composition may include a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector may contain at least one heterologous nucleic acid molecule(s), expresses in vivo in the animal VSV antigen(s), immunogen(s) or epitope(s) thereof, e.g., VSV G protein and/or VSV N protein and/or VSV M protein. The heterologous nucleic acid molecule(s) may be adjusted to the vector/mammalian cell system by codon optimization. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated.
摘要翻译: 本发明涉及一种免疫原性或疫苗组合物,以诱导针对VSV易感的动物中的水泡性口炎病毒(VSV)的免疫应答或保护性免疫应答。 组合物可以包括药学上或兽医学上可接受的载体或赋形剂和载体。 载体可以含有至少一种异源核酸分子,在体内表达动物VSV抗原,其免疫原或其表位,例如VSV G蛋白和/或VSV N蛋白,以及 /或VSV M蛋白。 可以通过密码子优化将异源核酸分子调整到载体/哺乳动物细胞系统。 组合物可以含有佐剂,如卡波姆。 还考虑制备和使用这种组合物的方法,包括初始 - 加强方案和包括鉴别诊断。
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公开(公告)号:US07862821B2
公开(公告)日:2011-01-04
申请号:US11444698
申请日:2006-06-01
IPC分类号: A61K39/15 , A61K39/275 , C12N7/01 , C12Q1/70 , G01N33/569
CPC分类号: C07K14/005 , A61K2039/5256 , C12N15/86 , C12N2710/24043 , C12N2720/12122 , C12N2720/12134 , G01N33/56983 , G01N33/6854
摘要: The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against Orbiviruses, more specifically bluetongue virus (BTV) in an animal susceptible to BTV infection. The composition may include a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector may contain heterologous nucleic acid molecule(s), expresses in vivo in the animal BTV antigen, immunogen or epitope thereof, e.g., BTV VP2; BTV VP2 and VP5; BTV VP2 and VP5 and VP3 and/or VP7. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated. AGACAGTGGTCAATTCCAATGGTACTGTTTGACGATAC
摘要翻译: 本发明涉及一种免疫原性或疫苗组合物,用于在易感BTV感染的动物中诱导针对罗非鱼病毒的免疫应答或保护性免疫应答,更具体地说是Bluetong病毒(BTV)。 组合物可以包括药学上或兽医学上可接受的载体或赋形剂和载体。 载体可以含有异源核酸分子,在体内在动物BTV抗原,免疫原或其表位例如BTV VP2中表达; BTV VP2和VP5; BTV VP2和VP5以及VP3和/或VP7。 组合物可以含有佐剂,如卡波姆。 还考虑制备和使用这种组合物的方法,包括初始 - 加强方案和包括鉴别诊断。 AGACAGTGGTCAATTCCAATGGTACTGTTTGACGATAC
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公开(公告)号:US20100119546A1
公开(公告)日:2010-05-13
申请号:US12604048
申请日:2009-10-22
申请人: Jules Maarten Minke , Jean-Christophe Audonnet , Alan John Guthrie , Nigel James Maclachlan , Jiansheng Yao
发明人: Jules Maarten Minke , Jean-Christophe Audonnet , Alan John Guthrie , Nigel James Maclachlan , Jiansheng Yao
CPC分类号: A61K39/15 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/86 , C12N2710/24043 , C12N2720/12122 , C12N2720/12134
摘要: The present invention provides vectors that contain and express in vivo the genes encoding VP2 and VP5 of African Horse Sickness Virus or an epitope thereof that elicits an immune response in a horse against African horse sickness virus, compositions comprising said vectors, methods of vaccination against African horse sickness virus, and kits for use with such methods and compositions.
摘要翻译: 本发明提供了在体内含有和表达编码非洲马疾病病毒VP2和VP5的基因或其在马中针对非洲马病病毒引起免疫应答的表位的载体,包含所述载体的组合物,针对非洲的疫苗接种方法 马病病毒,以及用于此类方法和组合物的试剂盒。
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公开(公告)号:US07384642B2
公开(公告)日:2008-06-10
申请号:US11211983
申请日:2005-08-25
申请人: Jules Maarten Minke , Kemal Karaca , Jiansheng Yao
发明人: Jules Maarten Minke , Kemal Karaca , Jiansheng Yao
IPC分类号: A61K39/145 , A61K39/00 , A61K39/285
CPC分类号: C12Q1/6888 , C12Q2600/158
摘要: The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.
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公开(公告)号:US20070048819A1
公开(公告)日:2007-03-01
申请号:US11211983
申请日:2005-08-25
申请人: Jules Minke , Kemal Karaca , Jiansheng Yao
发明人: Jules Minke , Kemal Karaca , Jiansheng Yao
CPC分类号: C12Q1/6888 , C12Q2600/158
摘要: The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.
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公开(公告)号:US20060073594A1
公开(公告)日:2006-04-06
申请号:US10958267
申请日:2004-10-05
IPC分类号: C12N15/863
CPC分类号: C12N7/00 , A61K2039/5256 , C12N15/86 , C12N2710/24043 , C12N2710/24143 , C12N2740/15022 , C12N2770/36122 , C12N2800/50 , Y02A50/383 , Y02A50/388 , Y02A50/466
摘要: The present invention relates to chimeric vectors. More specifically, the invention relates to recombinant poxvirus vectors and viruses that are capable of expressing an alphaviral RNA replicon expressing a heterologous sequence of interest.
摘要翻译: 本发明涉及嵌合载体。 更具体地,本发明涉及能够表达表达异源兴趣序列的甲病毒RNA复制子的重组痘病毒载体和病毒。
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