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1.发明授权5-carbamoyl-adamantan-2-yl amide derivatives, pharmaceutically acceptable salts thereof and preparation process thereof 有权5-氨基甲酰基 - 金刚烷-2-基酰胺衍生物及其药学上可接受的盐及其制备方法公开(公告)号：US09233957B2
公开(公告)日：2016-01-12
申请号：US14123043
申请日：2012-06-11
申请人： Coo-Min Chung , Choon-Ho Ryu , Yoon-Kyeong Lee , Jin-Sook Moon , Hye-Sung Lee , Seon-Jeong Lee , Kyung-Seok Oh
发明人： Coo-Min Chung , Choon-Ho Ryu , Yoon-Kyeong Lee , Jin-Sook Moon , Hye-Sung Lee , Seon-Jeong Lee , Kyung-Seok Oh
IPC分类号： C07D207/34 , C07D213/81 , C07D213/89 , C07D215/48 , C07D215/60 , C07D417/04 , C07D333/38 , C07D261/10 , C07D307/56 , C07D261/18 , C07D307/68 , C07D401/04 , C07D413/04 , C07D413/12
CPC分类号： C07D417/04 , C07D207/34 , C07D213/81 , C07D213/89 , C07D215/48 , C07D215/60 , C07D261/10 , C07D261/18 , C07D307/56 , C07D307/68 , C07D333/38 , C07D401/04 , C07D413/04 , C07D413/12
摘要： Provided are a novel derivative of 5-carbamoyl adamantan-2-yl amide of Formula (I), or a pharmaceutically acceptable salt thereof, and a pharmaceutical use thereof for inhibiting the activity of 11β-hydroxystreroid dehydrogenase type 1 (11b-HSD1) or for preventing and/or treating various diseases mediated by 11β-hydroxystreroid dehydrogenase type 1.
摘要翻译： 提供式（I）的5-氨基甲酰基金刚烷-2-基酰胺或其药学上可接受的盐的新型衍生物及其用于抑制11型β-葡萄糖醛酸脱氢酶1型（11b-HSD1）的活性的药物用途， 或用于预防和/或治疗由11型β-羟化神经元脱氢酶1介导的各种疾病。
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2.发明申请5-CARBAMOYL-ADAMANTAN-2-YL AMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND PREPARATION PROCESS THEREOF 有权5-卡巴酸 - 阿马丹-2-YL酰胺衍生物，其药用盐酸盐及其制备方法公开(公告)号：US20140128427A1
公开(公告)日：2014-05-08
申请号：US14123043
申请日：2012-06-11
申请人： Coo-Min Chung , Choon-Ho Ryu , Yoon-Kyeong Lee , Jin-Sook Moon , Hye-Sung Lee , Seon-Jeong Lee , Kyung-Seok Oh
发明人： Coo-Min Chung , Choon-Ho Ryu , Yoon-Kyeong Lee , Jin-Sook Moon , Hye-Sung Lee , Seon-Jeong Lee , Kyung-Seok Oh
IPC分类号： C07D417/04 , C07D261/18 , C07D413/04 , C07D401/04 , C07D207/34 , C07D215/48 , C07D333/38 , C07D413/12 , C07D307/68 , C07D213/81
CPC分类号： C07D417/04 , C07D207/34 , C07D213/81 , C07D213/89 , C07D215/48 , C07D215/60 , C07D261/10 , C07D261/18 , C07D307/56 , C07D307/68 , C07D333/38 , C07D401/04 , C07D413/04 , C07D413/12
摘要： Provided are a novel derivative of 5-carbamoyl adamantan-2-yl amide or a pharmaceutically acceptable salt thereof, and a pharmaceutical use thereof for inhibiting the activity of 11β-hydroxystreroid dehydrogenase type 1 (11b-HSD1) or for preventing and/or treating various diseases mediated by 11β-hydroxystreroid dehydrogenase type 1.
摘要翻译： 本发明提供5-氨基甲酰基金刚烷-2-基酰胺或其药学上可接受的盐的新型衍生物及其用于抑制11β-半胱氨酸脱氢酶1型（11b-HSD1）活性的药物用途，或用于预防和/或 治疗11型和β-羟化神经元脱氢酶1型介导的各种疾病。
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