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公开(公告)号：US08029817B2
公开(公告)日：2011-10-04
申请号：US12245554
申请日：2008-10-03
申请人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
IPC分类号： A61F2/00 , A61K9/14 , A61K33/42 , A61K33/00 , C01F11/00 , C01B25/32 , C01B33/24 , A01N59/26 , A01N59/00
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si-OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译： 本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。 硅取代的氧磷灰石化合物具有式Ca 5（PO 4）3-x（SiO 4）x O（1-x）/ 2，其中0
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公开(公告)号：US07498043B2
公开(公告)日：2009-03-03
申请号：US11088094
申请日：2005-03-24
申请人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译： 本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。 硅取代的氧磷灰石化合物具有式Ca 5（PO 4）3-x（SiO 4）x O（1-x）/ 2，其中0
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公开(公告)号：US20050244449A1
公开(公告)日：2005-11-03
申请号：US11088094
申请日：2005-03-24
申请人： Michael Sayer , Joel Reid , Timothy Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy Smith , Jason Hendry
IPC分类号： A61F13/00 , A61K33/42 , A61L24/00 , A61L27/12 , A61L27/32 , A61L27/42 , A61L27/46 , A61L27/54 , C01B15/16 , C01B25/32 , C01B33/20
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译： 本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。 硅取代的氧磷灰石化合物具有式Ca 3（PO 4）3-x（SiO 4） （1-x）/ 2 <0，其中0
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公开(公告)号：US20090030089A1
公开(公告)日：2009-01-29
申请号：US12245554
申请日：2008-10-03
申请人： Michael Sayer , Joel Reid , Timothy J.N. Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy J.N. Smith , Jason Hendry
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译： 本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。 硅取代的氧磷灰石化合物具有式Ca 5（PO 4）3-x（SiO 4）x O（1-x）/ 2，其中0
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5.发明授权Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity 有权磷酸钙相的合成生物材料化合物特别适用于支持骨细胞活性公开(公告)号：US06846493B2
公开(公告)日：2005-01-25
申请号：US10142151
申请日：2002-05-10
CPC分类号： C04B38/00 , A61F2310/00293 , A61L27/12 , C04B35/447 , C23C30/00
摘要： The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.
摘要翻译： 本发明涉及一种基于稳定的磷酸钙的合成生物材料化合物，更具体地涉及该化合物的分子，结构和物理表征。 化合物包括钙，氧和磷，其中至少一个元素被离子半径约为0.1至1.1的元素取代。 对化合物的具体分子和化学性质的了解允许在各种骨相关临床条件下开发化合物的多种用途。
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公开(公告)号：US06585992B2
公开(公告)日：2003-07-01
申请号：US09971148
申请日：2001-10-04
IPC分类号： A61L2700
CPC分类号： A61K35/32 , A61F2310/00293 , A61L27/12 , A61L27/3821 , A61L27/3895 , A61L27/505 , A61L27/56 , C04B35/447 , C04B38/00 , C04B2111/00836 , C23C24/08 , C23C30/00 , C04B38/0064 , C04B38/067
摘要： The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.
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7.发明授权Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity 失效磷酸钙相的合成生物材料化合物特别适用于支持骨细胞活性公开(公告)号：US06323146B1
公开(公告)日：2001-11-27
申请号：US09044749
申请日：1998-03-19
IPC分类号： C04B35447
CPC分类号： A61K35/32 , A61F2310/00293 , A61L27/12 , A61L27/3821 , A61L27/3895 , A61L27/505 , A61L27/56 , C04B35/447 , C04B38/00 , C04B2111/00836 , C23C24/08 , C23C30/00 , C04B38/0064 , C04B38/067
摘要： The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.
摘要翻译： 本发明涉及一种基于稳定的磷酸钙的合成生物材料化合物，更具体地涉及该化合物的分子，结构和物理表征。 化合物包括钙，氧和磷，其中至少一个元素被离子半径约为0.1至1.1的元素取代。 对化合物的具体分子和化学性质的了解允许在各种骨相关临床条件下开发化合物的多种用途。
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8.再颁专利Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity 有权磷酸钙相的合成生物材料化合物特别适用于支持骨细胞活性公开(公告)号：USRE41251E1
公开(公告)日：2010-04-20
申请号：US12022946
申请日：2008-01-30
IPC分类号： C04B35/447 , C04B41/87 , A61L27/00
CPC分类号： A61K35/32 , A61F2310/00293 , A61L27/12 , A61L27/3821 , A61L27/3895 , A61L27/505 , A61L27/56 , C04B35/447 , C04B38/00 , C04B2111/00836 , C23C24/08 , C23C30/00 , C04B38/0064 , C04B38/067
摘要： The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.
摘要翻译： 本发明涉及一种基于稳定的磷酸钙的合成生物材料化合物，更具体地涉及该化合物的分子，结构和物理表征。 化合物包括钙，氧和磷，其中至少一个元素被离子半径约为0.1至1.1的元素取代。 对化合物的具体分子和化学性质的了解允许在各种骨相关临床条件下开发化合物的多种用途。
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公开(公告)号：USRE36573E
公开(公告)日：2000-02-15
申请号：US938996
申请日：1997-09-26
CPC分类号： C04B35/62218 , C23C18/1208 , C23C18/1225 , C23C18/1241 , C23C18/1254 , C23C18/127 , C23C18/1295
摘要： A method for producing thick ceramic films of greater than 10 .mu.m on selected substrates is described. Conventional sol gel solutions are loaded with up to about 90% by weight of finely divided ceramic particles and mixed. The resulting slurry or paint can be either spun or dip coated or sprayed or painted onto a planar or other substrate, fired to remove the organic materials and to develop a microcrystalline structure. The fired film may then be heated. Composite films are also contemplated.
摘要翻译： 描述了在所选择的基底上生产大于10μm的厚陶瓷膜的方法。 常规的溶胶凝胶溶液装载高达约90重量％的细碎陶瓷颗粒并混合。 所得到的浆料或涂料可以是旋涂或浸涂或喷涂或涂在平面或其它基材上，烧制以除去有机材料并开发微晶结构。 然后可以加热烧制的膜。 也考虑复合膜。
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公开(公告)号：US5585136A
公开(公告)日：1996-12-17
申请号：US409127
申请日：1995-03-22
IPC分类号： C04B35/622 , C23C18/12 , B05D3/00
CPC分类号： C04B35/62218 , C23C18/1208 , C23C18/1225 , C23C18/1241 , C23C18/1254 , C23C18/127 , C23C18/1295
摘要： A method for producing thick ceramic films of greater than 10 .mu.m on selected substrates is described. Conventional sol gel solutions are loaded with up to about 90% by weight of finely divided ceramic particles and mixed. The resulting slurry or paint can be either spun or dip coated or sprayed or painted onto a planar or other substrate, fired to remove the organic materials and to develop a microcrystalline structure. The fired film may then be heated. Composite films are also contemplated.
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