公开(公告)号：US20120046199A1

公开(公告)日：2012-02-23

申请号：US13138847

申请日：2010-04-12

申请人： Robby Ruijtenbeek ,  Maria Helena Hilhorst ,  Arzu Umar ,  Johannes Albert Foekens ,  Johannes Wilhelmus Maria Martens

发明人： Robby Ruijtenbeek ,  Maria Helena Hilhorst ,  Arzu Umar ,  Johannes Albert Foekens ,  Johannes Wilhelmus Maria Martens

IPC分类号： C40B30/08 ,  C40B40/10 ,  C12Q1/48

CPC分类号： G01N33/57415 ,  C12Q1/485 ,  G01N33/74 ,  G01N2333/723 ,  G01N2800/52

摘要： The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples obtained from patients diagnosed with breast cancer.

摘要翻译： 本发明涉及确定患有乳腺癌的患者的雌激素受体状态的方法。 本发明还旨在提供用于预测诊断为乳腺癌的患者对具体药物的反应的方法和装置。 更具体地，本发明提供了通过研究从诊断为乳腺癌的患者获得的样品中的磷酸化水平和特征来测量激酶活性的方法。

公开(公告)号：US09075061B2

公开(公告)日：2015-07-07

申请号：US13138847

申请日：2010-04-12

申请人： Robby Ruijtenbeek ,  Maria Helena Hilhorst ,  Arzu Umar ,  Johannes Albert Foekens ,  Johannes Wilhelmus Maria Martens

发明人： Robby Ruijtenbeek ,  Maria Helena Hilhorst ,  Arzu Umar ,  Johannes Albert Foekens ,  Johannes Wilhelmus Maria Martens

IPC分类号： C12Q1/48 ,  C40B40/10 ,  C40B30/08 ,  G01N33/574 ,  G01N33/74

CPC分类号： G01N33/57415 ,  C12Q1/485 ,  G01N33/74 ,  G01N2333/723 ,  G01N2800/52

摘要： The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples obtained from patients diagnosed with breast cancer.

摘要翻译： 本发明涉及确定患有乳腺癌的患者的雌激素受体状态的方法。 本发明还旨在提供用于预测诊断为乳腺癌的患者对具体药物的反应的方法和装置。 更具体地，本发明提供了通过研究从诊断为乳腺癌的患者获得的样品中的磷酸化水平和特征来测量激酶活性的方法。