摘要:
Compounds of formula (I): wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6 alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.
摘要翻译:式(I)的化合物:其中; R1是氢或C1-6烷基; R 2是氢,C 1-6烷基,全卤代甲基C 0-5烷基-O-或C 1-6烷氧基; R3是氢,C1-6烷基或C1-6烷氧基C1-6烷基; R 4是氢,C 1-6烷基,全卤代甲基C 1-6烷基; 或未取代的C 3-6环烷基C 1-6烷基; A为C-R5或N; B为C-R6或N; D为C-R7或N; 条件是A,B和D中的至少一个为N; R5是氢或C1-6烷基; R6是氢或C1-6烷基; R7是氢,C1-6烷基,C1-6烷氧基或羟基; R8是氢或C1-6烷基,条件是R4和R8中的一个是氢; R9是氢或羟基; R 10是氢或C 1-6烷基; 其盐是PAD4抑制剂,并且可用于治疗各种疾病,例如类风湿性关节炎,血管炎,系统性红斑狼疮,溃疡性结肠炎,癌症,囊性纤维化,哮喘,皮肤红斑狼疮和牛皮癣。
摘要:
A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, and autoimmune conditions.
摘要:
A tetrachromatic color filter array comprises multiple pixels, each of which comprises first, second, third and fourth sub-pixels having first, second, third and fourth hues, P1, P2, P3 and P4 respectively, these first, second, third and fourth hues having first, second and third hue angles, h1, h2, h3 and h4 respectively. The hues of the sub-pixels such that h3 equals h1+(180°±10°) and h4 equals h2+(180°±10°) in the a*b* plane of the La*b* color space.
摘要翻译:四色滤色器阵列包括多个像素,每个像素包括分别具有第一,第二,第三和第四色调的第一,第二,第三和第四子像素P1,P2,P3和P4,这些第一,第二,第三和第四 分别具有第一,第二和第三色调角度的色调h1,h2,h3和h4。 在La * b *颜色空间的a * b *平面中,子像素的色调使得h3等于h1 +(180°±10°),h4等于h2 +(180°±10°)。
摘要:
A pluggable electronic module is provided that has an electronic component and a module body enclosing the electronic component. The module body has a first surface and a second surface. The first surface has a first area substantially parallel to the second surface and a second area that defines a non-zero angle with respect to the first area. The second area contacts a thermal sink to dissipate heat generated by the electronic component. The pluggable electronic module has a reduced insertion force in comparison with conventional pluggable electronic modules.
摘要:
A backplane for an electro-optic display comprises a plurality of pixel electrodes, and an adhesive layer disposed adjacent the backplane, the adhesive layer comprising a plurality of pixel regions disposed adjacent the pixel electrodes of the backplane, and at least one inter-pixel region disposed between two pixels of the backplane, the at least one inter-pixel region having at least one of a lower dielectric constant and a higher volume resistivity than the pixel regions of the adhesive layer.
摘要:
Eddy current loss is a significant problem in high speed permanent magnet alternator/motors. Leakage flux from the rotor magnets 32, which flows through any stationary electrically conductive material such as a bearing housing 12 will result in eddy current loss. The invention uses a magnetic flux barrier means 29,36 to prevent magnetic flux leakage from the magnets 32 to the stationary electrically conductive material 12. The flux barrier means may comprise a diverter disk 29 made from a magnetically permeable material which is located on the shaft 18 next to the rotor 26 and rotates integrally with the rotor. Alternatively it may comprise a barrier ring 36 made from an electrically conductive material which is stationary on the end of the stator 27 and extends across the air gap 38 between the rotor 26 and the stator 27.
摘要:
The invention relates to a method of combating an animal parasite in a host which comprises delivering an anti-parasitic protein to the parasite or to a locus thereof by administering the protein to the host animal as a medicament or as a food. The anti-parasitic protein may be an inhibitor of an enzyme of the parasite, for example an inhibitor of a digestive enzyme such as a cysteine protease inhibitor. The parasite may be a helminth or a protozoan, for example, a nematode. According to one embodiment the anti-parasitic protein is expressed in a transgenic plant which may be a dietary crop for the host animal.
摘要:
In a memory system comprising a plurality of memory units each of which possesses unit-level error correction capabilities and each of which is tied to a system level error correction function, memory reliability is enhanced by providing a mechanism for disabling the unit-level error correction capability, for example, in response to the occurrence of an uncorrectable error in one of the memory units. This counter-intuitive approach which disables an error correction function nonetheless enhances overall memory system reliability since it enables the employment of the complement/recomplement algorithm which depends upon the presence of reproducible errors for proper operation. Thus, chip level error correction systems, which are increasingly desirable at high packaging densities, are employed in a way which does not interfere with system level error correction methods.