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公开(公告)号:US20120185178A1
公开(公告)日:2012-07-19
申请号:US13431021
申请日:2012-03-27
申请人: Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
发明人: Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
CPC分类号: G06F19/20
摘要: Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.
摘要翻译: 公开了用于分析可选拼接的方法和软件产品。 一般来说,这些方法涉及将探针组或外显子强度标准化为基因的表达水平测量。 该方法可用于鉴定组织特异性选择性剪接事件。
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公开(公告)号:US20080318312A1
公开(公告)日:2008-12-25
申请号:US12163435
申请日:2008-06-27
CPC分类号: C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要: The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes.
摘要翻译: 本发明提供胰岛转录因子和治疗和诊断糖尿病的方法。
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公开(公告)号:US07405289B2
公开(公告)日:2008-07-29
申请号:US10533593
申请日:2003-11-13
CPC分类号: C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要: The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes.
摘要翻译: 本发明提供胰岛转录因子和治疗和诊断糖尿病的方法。
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公开(公告)号:US20110208500A1
公开(公告)日:2011-08-25
申请号:US13100397
申请日:2011-05-04
申请人: Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
发明人: Alan Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson Clark
IPC分类号: G06G7/48
CPC分类号: G06F19/20
摘要: Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.
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公开(公告)号:US20110166037A1
公开(公告)日:2011-07-07
申请号:US13015370
申请日:2011-01-27
申请人: Yanxiang Cao , Shivani Nautiyal , Charles G. Miyada , Christopher Davies , Gangwu Mei , Alan J Williams , Eric B. Schell , John E. Blume
发明人: Yanxiang Cao , Shivani Nautiyal , Charles G. Miyada , Christopher Davies , Gangwu Mei , Alan J Williams , Eric B. Schell , John E. Blume
IPC分类号: C40B30/04
CPC分类号: C12Q1/6883 , C12Q1/6837 , C12Q2600/154 , C12Q2523/125
摘要: Arrays for genome-wide analysis of methylation are disclosed. IN a preferred aspect arrays comprising a plurality of probes complementary to a plurality of identified CpG islands in the human, mouse and rat genome are disclosed. The arrays may be used to detect methylation within cpG islands in samples from human, mouse and rat genomes.
摘要翻译: 公开了用于甲基化的全基因组分析的阵列。 在优选的方面,公开了包含与人,小鼠和大鼠基因组中的多个鉴定的CpG岛互补的多个探针的阵列。 阵列可用于检测来自人,小鼠和大鼠基因组的样品中cpG岛内的甲基化。
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公开(公告)号:US07901882B2
公开(公告)日:2011-03-08
申请号:US11695599
申请日:2007-04-02
申请人: Yanxiang Cao , Shivani Nautiyal , Charles G. Miyada , Christopher Davies , Gangwu Mei , Alan J. Williams , Eric B. Schell , John E. Blume
发明人: Yanxiang Cao , Shivani Nautiyal , Charles G. Miyada , Christopher Davies , Gangwu Mei , Alan J. Williams , Eric B. Schell , John E. Blume
CPC分类号: C12Q1/6883 , C12Q1/6837 , C12Q2600/154 , C12Q2523/125
摘要: Arrays for genome-wide analysis of methylation are disclosed. In a preferred aspect arrays comprising a plurality of probes complementary to a plurality of identified CpG islands in the human, mouse and rat genome are disclosed. The arrays may be used to detect methylation within CpG islands in samples from human, mouse and rat genomes.
摘要翻译: 公开了用于甲基化的全基因组分析的阵列。 在优选的方面,公开了包含与人,小鼠和大鼠基因组中的多个鉴定的CpG岛互补的多个探针的阵列。 阵列可用于检测来自人,小鼠和大鼠基因组的样品中CpG岛内的甲基化。
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公开(公告)号:US07294698B2
公开(公告)日:2007-11-13
申请号:US11591992
申请日:2006-11-01
申请人: Jeffrey D Johnson , John E. Blume , John F. Palma , Yun-Ping Zhou
发明人: Jeffrey D Johnson , John E. Blume , John F. Palma , Yun-Ping Zhou
CPC分类号: C07K14/47
摘要: The invention relates to methods and reagents for diagnosing and treating diabetes.
摘要翻译: 本发明涉及用于诊断和治疗糖尿病的方法和试剂。
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公开(公告)号:US07144985B2
公开(公告)日:2006-12-05
申请号:US10308393
申请日:2002-12-02
CPC分类号: C07K14/47
摘要: The invention relates to methods of determining islet cell activity by detecting the level of Archipelin or a fragment thereof and comparing the level to a baseline level or range associated with a known islet cell activity. Such methods are useful in diagnosing and studying the development of diabetes.
摘要翻译: 本发明涉及通过检测群岛蛋白或其片段的水平来确定胰岛细胞活性的方法,并将该水平与与已知胰岛细胞活性相关联的基线水平或范围进行比较。 这些方法可用于诊断和研究糖尿病的发展。
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公开(公告)号:US07053180B2
公开(公告)日:2006-05-30
申请号:US10459190
申请日:2003-06-10
CPC分类号: G01N33/6872 , C07K14/705 , G01N2500/04 , G01N2500/10
摘要: The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposition for diabetes.
摘要翻译: 本发明提供编码钾通道的多核苷酸以及使用钾通道治疗和诊断糖尿病和糖尿病倾向的方法。
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公开(公告)号:US08170808B2
公开(公告)日:2012-05-01
申请号:US13100397
申请日:2011-05-04
申请人: Alan J. Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson A. Clark
发明人: Alan J. Williams , Simon Cawley , John E. Blume , Hui Wang , Tyson A. Clark
CPC分类号: G06F19/20
摘要: Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.
摘要翻译: 公开了用于分析可选拼接的方法和软件产品。 一般来说,这些方法涉及将探针组或外显子强度标准化为基因的表达水平测量。 该方法可用于鉴定组织特异性选择性剪接事件。
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