公开(公告)号：US20110063427A1

公开(公告)日：2011-03-17

申请号：US12933512

申请日：2009-03-18

申请人： John Fengler ,  Paul Westwick ,  Arthur E. Bailey ,  Paul Cottle

发明人： John Fengler ,  Paul Westwick ,  Arthur E. Bailey ,  Paul Cottle

IPC分类号： H04N5/33 ,  H04N7/18

CPC分类号： A61B5/0086 ,  A61B1/00009 ,  A61B1/00043 ,  A61B1/00045 ,  A61B1/0005 ,  A61B1/00163 ,  A61B1/00186 ,  A61B1/04 ,  A61B1/042 ,  A61B1/043 ,  A61B1/045 ,  A61B1/06 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/418 ,  A61B5/7425 ,  G06T2207/10048 ,  H04N5/33 ,  H04N5/332

摘要： An imaging system for acquisition of NIR and full-color images includes a light source providing visible light and NIR light to an area under observation, such as living tissue, a camera having one or more image sensors configured to separately detect blue reflectance light, green reflectance light, and combined red reflectance light/detected NIR light returned from the area under observation. A controller in signal communication with the light source and the camera is configured to control the light source to continuously illuminate area under observation with temporally continuous blue/green illumination light and with red illumination light and NIR excitation light. At least one of the red illumination light and NIR excitation light are switched on and off periodically in synchronism with the acquisition of red and NIR light images in the camera.

摘要翻译： 用于获取NIR和全色图像的成像系统包括向可观察的区域提供可见光和NIR光的光源，例如活组织，具有一个或多个图像传感器的相机，其被配置为分别检测蓝色反射光，绿色 反射光和从观察区域返回的红外反射光/检测到的NIR光。 与光源和摄像机进行信号通信的控制器被配置为控制光源，以连续地照亮在时间上连续的蓝/绿照明光和红色照明光和NIR激发光下的观察区域。 与摄像机中的红色和NIR光图像的获取同步，周期性地打开和关闭红外照明光和NIR激发光中的至少一个。

公开(公告)号：US09173554B2

公开(公告)日：2015-11-03

申请号：US12933512

申请日：2009-03-18

申请人： John Fengler ,  Paul Westwick ,  Arthur E. Bailey ,  Paul Cottle

发明人： John Fengler ,  Paul Westwick ,  Arthur E. Bailey ,  Paul Cottle

IPC分类号： A61B1/04 ,  A61B1/00 ,  A61B1/06 ,  A61B5/00 ,  A61B1/045 ,  H04N5/33

CPC分类号： A61B5/0086 ,  A61B1/00009 ,  A61B1/00043 ,  A61B1/00045 ,  A61B1/0005 ,  A61B1/00163 ,  A61B1/00186 ,  A61B1/04 ,  A61B1/042 ,  A61B1/043 ,  A61B1/045 ,  A61B1/06 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/418 ,  A61B5/7425 ,  G06T2207/10048 ,  H04N5/33 ,  H04N5/332

摘要： An imaging system for acquisition of NIR and full-color images includes a light source providing visible light and NIR light to an area under observation, such as living tissue, a camera having one or more image sensors configured to separately detect blue reflectance light, green reflectance light, and combined red reflectance light/detected NIR light returned from the area under observation. A controller in signal communication with the light source and the camera is configured to control the light source to continuously illuminate area under observation with temporally continuous blue/green illumination light and with red illumination light and NIR excitation light. At least one of the red illumination light and NIR excitation light are switched on and off periodically in synchronism with the acquisition of red and NIR light images in the camera.

摘要翻译： 用于获取NIR和全色图像的成像系统包括向可观察的区域提供可见光和NIR光的光源，例如活组织，具有一个或多个图像传感器的相机，其被配置为分别检测蓝色反射光，绿色 反射光和从观察区域返回的红外反射光/检测到的NIR光。 与光源和摄像机进行信号通信的控制器被配置为控制光源，以连续地照亮在时间上连续的蓝/绿照明光和红色照明光和NIR激发光下的观察区域。 与摄像机中的红色和NIR光图像的获取同步，周期性地打开和关闭红外照明光和NIR激发光中的至少一个。

公开(公告)号：US20070015963A1

公开(公告)日：2007-01-18

申请号：US11412715

申请日：2006-04-26

申请人： John Fengler ,  Francis Regamey

发明人： John Fengler ,  Francis Regamey

IPC分类号： A61B1/04 ,  A61B6/00

CPC分类号： A61B1/043 ,  A61B1/00006 ,  A61B1/00009 ,  A61B1/00045 ,  A61B1/00101 ,  A61B1/00186 ,  A61B1/05 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0661 ,  G02B23/2423 ,  H04N5/2254 ,  H04N5/2256 ,  H04N2005/2255

摘要： A fluorescence endoscopy video system includes a multi-mode light source that produces light for white light and fluorescence imaging modes. A filter is positioned at the distal end of an imaging endoscope so that the endoscope can produce fluorescence and white light images of a tissue sample.

摘要翻译： 荧光内窥镜视频系统包括产生用于白光和荧光成像模式的光的多模光源。 过滤器位于成像内窥镜的远端，使得内窥镜能够产生组织样本的荧光和白光图像。

公开(公告)号：US20050154319A1

公开(公告)日：2005-07-14

申请号：US11009965

申请日：2004-12-10

申请人： Richard Cline ,  John Fengler

发明人： Richard Cline ,  John Fengler

IPC分类号： A61B1/00 ,  A61B1/04 ,  A61B1/06 ,  A61B5/00 ,  A61B6/00

CPC分类号： A61B1/0638 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  A61B6/4464

摘要： A fluorescence endoscopy video system includes a multi-mode light source that produces light for white light and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for white light and fluorescence imaging, which may be located in the insertion portion of the endoscope, or attached to the portion of the endoscope outside the body. The camera can be utilized for both white light imaging and fluorescence imaging, and in its most compact form, contains no moving parts.

公开(公告)号：US08408269B2

公开(公告)日：2013-04-02

申请号：US11830323

申请日：2007-07-30

申请人： John Fengler ,  John Senger ,  Gary Jenne

发明人： John Fengler ,  John Senger ,  Gary Jenne

IPC分类号： B29C65/48 ,  B29C65/56 ,  B29C65/78 ,  B32B37/10 ,  B32B37/12 ,  B32B37/14 ,  G02B5/20 ,  G02B7/02 ,  G02B3/00

CPC分类号： A61B1/00101 ,  A61B1/00096 ,  A61B1/0011 ,  A61B1/00126 ,  A61B1/00144 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0646 ,  Y10T156/17 ,  Y10T156/1798 ,  Y10T156/18

摘要： An applicator suitable for converting a white-light endoscope into an endoscope for combined white-light/fluorescence imaging is disclosed. The applicator facilitates attachment of an optical element, for example an optical filter, to a distal optical port of an endoscope. The applicator engages with alignment feature on the endoscope's distal end and releasably supports the optical element in an opening that is aligned with the optical port. The optical element is released in a proximal direction by pressing down on an actuator.

摘要翻译： 公开了一种适用于将白光内窥镜转换成用于组合的白光/荧光成像的内窥镜的施加器。 该施用器有助于将光学元件（例如光学滤光器）附接到内窥镜的远端光学端口。 施用器与内窥镜的远端上的对准特征接合并且将光学元件可释放地支撑在与光学端口对准的开口中。 通过向下按压致动器，光学元件沿近端方向释放。

公开(公告)号：US20070102623A1

公开(公告)日：2007-05-10

申请号：US11546013

申请日：2006-10-10

申请人： John Fengler ,  Paul Westwick ,  Joachim Boehm

发明人： John Fengler ,  Paul Westwick ,  Joachim Boehm

IPC分类号： H01L27/00

CPC分类号： A61B1/00009 ,  A61B1/00186 ,  A61B5/0084

摘要： A system for performing short wavelength imaging with a broadband illumination source includes an image processor that receives signals from a color image sensor. The image processor reduces the contribution of red illumination light to an image by computing blue, green, and blue-green (cyan) color components of display pixels from the signals received from the image sensor. The blue, green, and cyan color component values are coupled to inputs of a color monitor for display to produce a false color image of the tissue.

摘要翻译： 用宽带照明源执行短波长成像的系统包括从彩色图像传感器接收信号的图像处理器。 图像处理器通过从从图像传感器接收的信号计算显示像素的蓝色，绿色和蓝色（青色）颜色分量来减少红色照明光对图像的贡献。 蓝色，绿色和青色颜色分量值耦合到用于显示的彩色监视器的输入以产生组织的假彩色图像。

公开(公告)号：US20050065406A1

公开(公告)日：2005-03-24

申请号：US10899648

申请日：2004-07-26

申请人： Richard Cline ,  John Fengler ,  Joachim Boehm

发明人： Richard Cline ,  John Fengler ,  Joachim Boehm

IPC分类号： G02B23/24 ,  A61B1/00 ,  A61B1/04 ,  A61B1/06 ,  A61B5/00 ,  H04N7/18 ,  H04N9/04

CPC分类号： A61B5/0071 ,  A61B1/00009 ,  A61B1/00057 ,  A61B1/00186 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/06 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/2676 ,  A61B5/0084 ,  G01N21/6458 ,  G06F19/00

摘要： A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.

摘要翻译： 荧光内窥镜视频系统包括产生用于彩色和荧光成像模式的光的多模光源。 来自光源的光通过内窥镜透射到观察的组织。 该系统还包括一个用于彩色和荧光成像的小型相机。 通过内窥镜获得的图像通过照相机中的固定分束器被光学分割并投影到一个或多个图像传感器上。 固定分束器不需要将可移动反射镜插入到内窥镜和图像传感器之间的光路中。 来自相机的图像信号在可应用对比度增强功能的系统处理器/控制器中进行处理。 对比度增强功能增加了早期癌症可疑的正常组织和组织之间的颜色对比。 最后，该系统还包括校准特征，从而当与不同的内窥镜一起使用时可以维持系统性能。

公开(公告)号：US20080027280A1

公开(公告)日：2008-01-31

申请号：US11830323

申请日：2007-07-30

申请人： John Fengler ,  John Senger ,  Gary Jenne

发明人： John Fengler ,  John Senger ,  Gary Jenne

IPC分类号： A61B1/04

CPC分类号： A61B1/00101 ,  A61B1/00096 ,  A61B1/0011 ,  A61B1/00126 ,  A61B1/00144 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0646 ,  Y10T156/17 ,  Y10T156/1798 ,  Y10T156/18

摘要： An applicator suitable for converting a white-light endoscope into an endoscope for combined white-light/fluorescence imaging is disclosed. The applicator facilitates attachment of an optical element, for example an optical filter, to a distal optical port of an endoscope. The applicator engages with alignment feature on the endoscope's distal end and releasably supports the optical element in an opening that is aligned with the optical port. The optical element is released in a proximal direction by pressing down on an actuator.

摘要翻译： 公开了一种适用于将白光内窥镜转换成用于组合的白光/荧光成像的内窥镜的施加器。 该施用器有助于将光学元件（例如光学滤光器）附接到内窥镜的远端光学端口。 施用器与内窥镜的远端上的对准特征接合并且将光学元件可释放地支撑在与光学端口对准的开口中。 通过向下按压致动器，光学元件沿近端方向释放。

公开(公告)号：US08498695B2

公开(公告)日：2013-07-30

申请号：US11964330

申请日：2007-12-26

申请人： Paul Westwick ,  David Potkins ,  John Fengler

发明人： Paul Westwick ,  David Potkins ,  John Fengler

IPC分类号： A61B6/00

CPC分类号： H04N7/183 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/128 ,  A61B3/18 ,  H04N5/2256 ,  H04N9/045 ,  H04N2005/2255

摘要： An endoscopic video system and method using a camera with a single color image sensor, for example a CCD color image sensor, for fluorescence and color imaging and for simultaneously displaying the images acquired in these imaging modes at video rates in real time is disclosed. The tissue under investigation is illuminated continuously with fluorescence excitation light and is further illuminated periodically using visible light outside of the fluorescence excitation wavelength range. The illumination sources may be conventional lamps using filters and shutters, or may include light-emitting diodes mounted at the distal tip of the endoscope.

公开(公告)号：US20080239070A1

公开(公告)日：2008-10-02

申请号：US11964330

申请日：2007-12-26

申请人： Paul Westwick ,  David Potkins ,  John Fengler

发明人： Paul Westwick ,  David Potkins ,  John Fengler

IPC分类号： H04N7/18

CPC分类号： H04N7/183 ,  A61B1/041 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/128 ,  A61B3/18 ,  H04N5/2256 ,  H04N9/045 ,  H04N2005/2255

摘要： An endoscopic video system and method using a camera with a single color image sensor, for example a CCD color image sensor, for fluorescence and color imaging and for simultaneously displaying the images acquired in these imaging modes at video rates in real time is disclosed. The tissue under investigation is illuminated continuously with fluorescence excitation light and is further illuminated periodically using visible light outside of the fluorescence excitation wavelength range. The illumination sources may be conventional lamps using filters and shutters, or may include light-emitting diodes mounted at the distal tip of the endoscope.

摘要翻译： 公开了一种使用具有用于荧光和彩色成像的单色彩色图像传感器（例如CCD彩色图像传感器）的相机和用于以视频速率实时显示在这些成像模式中获取的图像的内窥镜视频系统和方法。 用荧光激发光连续照射被研究的组织，并使用荧光激发波长范围外的可见光进一步周期性地照射。 照明源可以是使用过滤器和百叶窗的常规灯，或者可以包括安装在内窥镜的远端的发光二极管。