公开(公告)号：US5820918A

公开(公告)日：1998-10-13

申请号：US679608

申请日：1996-07-11

申请人： John M. Ronan ,  Samuel A. Thompson

发明人： John M. Ronan ,  Samuel A. Thompson

IPC分类号： A61L27/50 ,  A61L27/54 ,  A61L29/16 ,  A61L29/18 ,  A61L31/16 ,  A61L31/18 ,  A61M25/00 ,  B05D1/18 ,  B05D1/36 ,  B05D7/24

CPC分类号： A61L27/54 ,  A61L27/50 ,  A61L29/16 ,  A61L29/18 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  Y10S623/924

摘要： A process for impregnating a medical device made from a water absorbable polymer material, e.g., a hydrogel, with a medical compound having low solubility in aqueous solutions, e.g., an antiseptic or radiopaque compound, is disclosed. The device is first infiltrated with an aqueous solution containing a first water soluble, ionizable compound, and subsequently infiltrated with an aqueous solution containing a second water soluble, ionizable compound. The ionizable compounds are selected such that they react after mutual contact to form the medical compound in-situ within the device.

摘要翻译： 公开了一种浸渍由可吸水聚合物材料（例如水凝胶）制成的医疗装置与在水溶液中具有低溶解度的医药化合物例如防腐剂或不透射线化合物的方法。 该装置首先用含有第一水溶性可电离化合物的水溶液渗透，随后用含有第二水溶性可电离化合物的水溶液渗透。 选择可电离化合物使得它们在相互接触之后反应以在装置内原位形成医用化合物。

公开(公告)号：US06368356B1

公开(公告)日：2002-04-09

申请号：US09512698

申请日：2000-02-25

申请人： Sheng Ping Zhong ,  Arthur R. Madenjian ,  Douglas E. Godshall ,  John M. Ronan ,  Samuel A. Thompson

发明人： Sheng Ping Zhong ,  Arthur R. Madenjian ,  Douglas E. Godshall ,  John M. Ronan ,  Samuel A. Thompson

IPC分类号： A61F204

CPC分类号： A61M27/008 ,  A61F2/82 ,  A61L27/50 ,  A61L27/52 ,  A61L29/14 ,  A61L29/145 ,  A61L31/145 ,  A61L31/18 ,  C08B37/00 ,  C08B37/0084 ,  C08J3/243 ,  C08J2300/14 ,  Y10S524/918 ,  Y10S525/903 ,  Y10S623/925 ,  Y10S623/926

摘要： The invention provides a means of boosting the mechanical performance of shaped shaped medical devices comprising polymer hydrogels, such as stents, so that they may be more easily inserted into or removed from the body. In one aspect, the invention provides shaped medical devices having increased mechanical strength and comprising both ionic and covalent crosslinks. In another aspect, the invention provides a shaped medical device having a heterogeneous polymer composition and a variable dissolution or degradation rate along its length. The shaped medical devices according to the present invention retain their shape and stiffness during insertion into the body and can swell and soften inside the body to enhance patient comfort.

摘要翻译： 本发明提供了一种增强包括聚合物水凝胶（例如支架）的成形医疗装置的机械性能的方法，使得它们可以更容易地插入身体或从身体移除。 在一个方面，本发明提供具有增加的机械强度并且包含离子和共价交联的成形医疗装置。 另一方面，本发明提供一种具有非均相聚合物组合物并且其长度可变的溶解或降解速率的成形医疗装置。 根据本发明的成形医疗装置在插入身体期间保持其形状和刚度，并且可以在身体内部膨胀和软化以增强患者的舒适度。

公开(公告)号：US06184266B2

公开(公告)日：2001-02-06

申请号：US09496709

申请日：2000-02-02

申请人： John M. Ronan ,  Samuel A. Thompson

发明人： John M. Ronan ,  Samuel A. Thompson

IPC分类号： A61K922

CPC分类号： A61M27/008 ,  A61F2/82 ,  A61L29/145 ,  A61L31/145 ,  C08B37/00 ,  C08B37/0084 ,  C08J3/243 ,  C08J2300/14 ,  Y10S524/916 ,  Y10S525/903 ,  Y10S623/901

摘要： Shaped medical devices, e.g. stents, having improved mechanical properties and structural integrity are disclosed. The devices comprise shaped polymeric hydrogels which are both ionically and non-ionically crosslinked and which exhibit improved structural integrity after selective removal of the crosslinking ions. Process for making such devices are also disclosed wherein an ionically crosslinkable polymer is both ionically and non-ionically crosslinked to form a shaped medical device. When implanted in the body, selective in-vivo stripping of the crosslinking ions produces a softer, more flexible implant having improved structural integrity.

摘要翻译： 形状的医疗装置，例如 公开了具有改进的机械性能和结构完整性的支架。 这些装置包括离子和非离子交联的成形聚合物水凝胶，并且在选择性除去交联离子之后表现出改善的结构完整性。 还公开了制备这种装置的方法，其中离子交联聚合物既离子交联又非离子交联以形成成形医疗装置。 当植入体内时，交联离子的选择性体内剥离产生具有改善的结构完整性的较软，更柔性的植入物。

公开(公告)号：US06387978B2

公开(公告)日：2002-05-14

申请号：US09757396

申请日：2001-01-08

申请人： John M. Ronan ,  Samuel A. Thompson

发明人： John M. Ronan ,  Samuel A. Thompson

IPC分类号： A61K922

CPC分类号： A61M27/008 ,  A61F2/82 ,  A61L29/145 ,  A61L31/145 ,  C08B37/00 ,  C08B37/0084 ,  C08J3/243 ,  C08J2300/14 ,  Y10S524/916 ,  Y10S525/903 ,  Y10S623/901

摘要： Shaped-medical devices, e.g. stents, having improved mechanical properties and structural integrity are disclosed. The devices comprise shaped polymeric hydrogels which are both ionically and non-ionically crosslinked and which exhibit improved structural integrity after selective removal of the crosslinking ions. Process for making such devices are also disclosed wherein an ionically crosslinkable polymer is both ionically and non-ionically crosslinked to form a shaped medical device. When implanted in the body, selective in-vivo stripping of the crosslinking ions produces a softer, more flexible implant having improved structural integrity.

摘要翻译： 成形医疗器械，例如 公开了具有改进的机械性能和结构完整性的支架。 这些装置包括离子和非离子交联的成形聚合物水凝胶，并且在选择性除去交联离子之后表现出改善的结构完整性。 还公开了制备这种装置的方法，其中离子交联聚合物既离子交联又非离子交联以形成成形医疗装置。 当植入体内时，交联离子的选择性体内剥离产生具有改善的结构完整性的较软，更柔性的植入物。

公开(公告)号：US6060534A

公开(公告)日：2000-05-09

申请号：US679609

申请日：1996-07-11

申请人： John M. Ronan ,  Samuel A. Thompson

发明人： John M. Ronan ,  Samuel A. Thompson

IPC分类号： A61F2/82 ,  A61K9/22 ,  A61L29/14 ,  A61L31/14 ,  C08B37/00 ,  C08J3/24 ,  C08K3/24

CPC分类号： A61M27/008 ,  A61L29/145 ,  A61L31/145 ,  C08B37/00 ,  C08B37/0084 ,  C08J3/243 ,  A61F2/82 ,  C08J2300/14 ,  Y10S524/916 ,  Y10S525/903 ,  Y10S623/901

摘要： Shaped medical devices, e.g. stents, having improved mechanical properties and structural integrity are disclosed. The devices comprise shaped polymeric hydrogels which are both ionically and non-ionically crosslinked and which exhibit improved structural integrity after selective removal of the crosslinking ions. Process for making such devices are also disclosed wherein an ionically crosslinkable polymer is both ionically and non-ionically crosslinked to form a shaped medical device. When implanted in the body, selective in-vivo stripping of the crosslinking ions produces a softer, more flexible implant having improved structural integrity.

摘要翻译： 形状的医疗装置，例如 公开了具有改进的机械性能和结构完整性的支架。 这些装置包括离子和非离子交联的成形聚合物水凝胶，并且在选择性除去交联离子之后表现出改善的结构完整性。 还公开了制备这种装置的方法，其中离子交联聚合物既离子交联又非离子交联以形成成形医疗装置。 当植入体内时，交联离子的选择性体内剥离产生具有改善的结构完整性的较软，更柔性的植入物。