公开(公告)号：US07670384B2

公开(公告)日：2010-03-02

申请号：US11407409

申请日：2006-04-19

申请人： Mukesh Kumar ,  Ned M. Hamman ,  Michael D. Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl L. Carter

发明人： Mukesh Kumar ,  Ned M. Hamman ,  Michael D. Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl L. Carter

IPC分类号： A61F2/28 ,  A61K35/32

CPC分类号： A61L27/365 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/02 ,  A61M5/204 ,  A61M5/3129

摘要： Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.

摘要翻译： 用于施用于人或动物受试者的骨表面的成形组合物，包括：骨材料; 以及包含变性软化骨的载体，其中所述组合物形成适于施用于骨的形状。 提供用于制备用于施用于人或动物对象的骨表面的成形组合物的方法包括混合脱矿质骨和水; 加热混合物形成载体; 将载体与骨混合以形成可成型组合物; 并模塑可模制组合物以产生形成的组合物。 提供了几种用于水合形成的骨组合物的装置。 还提供了水合形成的骨组合物的方法。

公开(公告)号：US20090149774A1

公开(公告)日：2009-06-11

申请号：US11951688

申请日：2007-12-06

申请人： Bruce J. Simon ,  John Manocchio

发明人： Bruce J. Simon ,  John Manocchio

IPC分类号： A61B10/00

CPC分类号： A61B10/025 ,  A61B10/0283 ,  A61B2010/0258

摘要： A bone aspiration needle is provided. The cannulated body can define at least a first aperture for aspirating bone marrow from a first region of an anatomy. The bone aspiration needle can also include a second aperture for aspirating bone marrow from a second region of the anatomy and a third aperture for aspirating bone marrow from a third region of the anatomy. The first aperture can be a distal most aperture and the third aperture can be a proximal most aperture. The first aperture can have a first area, the second aperture can have a second area, and the third aperture can have a third area. The second area can be greater than the first area and less than the third area so as to enable the aspiration of substantially equal amounts of bone marrow substantially simultaneously from each of the first aperture, second aperture and third aperture.

摘要翻译： 提供骨吸液针。 插管体可以限定至少一个用于从解剖结构的第一区域吸取骨髓的第一孔。 骨抽吸针还可以包括用于从解剖结构的第二区域吸取骨髓的第二孔和用于从解剖结构的第三区域抽吸骨髓的第三孔。 第一孔可以是最远端的孔，第三孔可以是最近孔。 第一孔可具有第一区域，第二孔可具有第二区域，第三孔可具有第三区域。 第二区域可以大于第一区域并且小于第三区域，以便能够从第一孔径，第二孔径和第三孔隙中的每一个基本上同时吸入基本相等量的骨髓。

公开(公告)号：US20060280803A1

公开(公告)日：2006-12-14

申请号：US11407409

申请日：2006-04-19

申请人： Mukesh Kumar ,  Ned Hamman ,  Michael Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl Carter

发明人： Mukesh Kumar ,  Ned Hamman ,  Michael Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl Carter

IPC分类号： A61K35/32

CPC分类号： A61L27/365 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/02 ,  A61M5/204 ,  A61M5/3129

摘要： Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.

摘要翻译： 用于施用于人或动物受试者的骨表面的成形组合物，包括：骨材料; 以及包含变性软化骨的载体，其中所述组合物形成适于施用于骨的形状。 提供用于制备用于施用于人或动物对象的骨表面的成形组合物的方法包括混合脱矿质骨和水; 加热混合物形成载体; 将载体与骨混合以形成可成型组合物; 并模塑可模制组合物以产生形成的组合物。 提供了几种用于水合形成的骨组合物的装置。 还提供了水合形成的骨组合物的方法。