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    Method and apparatus for repairing bone
    1.
    发明申请
    Method and apparatus for repairing bone 有权
    骨修复方法及装置

    公开(公告)号：US20060280803A1

    公开(公告)日：2006-12-14

    申请号：US11407409

    申请日：2006-04-19

    申请人： Mukesh Kumar ,  Ned Hamman ,  Michael Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl Carter

    发明人： Mukesh Kumar ,  Ned Hamman ,  Michael Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl Carter

    IPC分类号： A61K35/32

    CPC分类号： A61L27/365 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/02 ,  A61M5/204 ,  A61M5/3129

    摘要： Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.

    摘要翻译： 用于施用于人或动物受试者的骨表面的成形组合物，包括：骨材料; 以及包含变性软化骨的载体，其中所述组合物形成适于施用于骨的形状。 提供用于制备用于施用于人或动物对象的骨表面的成形组合物的方法包括混合脱矿质骨和水; 加热混合物形成载体; 将载体与骨混合以形成可成型组合物; 并模塑可模制组合物以产生形成的组合物。 提供了几种用于水合形成的骨组合物的装置。 还提供了水合形成的骨组合物的方法。

    Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
    2.
    发明授权
    Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone 有权
    骨移植组合物，其包含骨材料和包含变性脱矿质骨的载体

    公开(公告)号：US07670384B2

    公开(公告)日：2010-03-02

    申请号：US11407409

    申请日：2006-04-19

    申请人： Mukesh Kumar ,  Ned M. Hamman ,  Michael D. Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl L. Carter

    发明人： Mukesh Kumar ,  Ned M. Hamman ,  Michael D. Leach ,  John Manocchio ,  Paul D'Antonio ,  Daryl L. Carter

    IPC分类号： A61F2/28 ,  A61K35/32

    CPC分类号： A61L27/365 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/02 ,  A61M5/204 ,  A61M5/3129

    摘要： Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.

    摘要翻译： 用于施用于人或动物受试者的骨表面的成形组合物，包括：骨材料; 以及包含变性软化骨的载体，其中所述组合物形成适于施用于骨的形状。 提供用于制备用于施用于人或动物对象的骨表面的成形组合物的方法包括混合脱矿质骨和水; 加热混合物形成载体; 将载体与骨混合以形成可成型组合物; 并模塑可模制组合物以产生形成的组合物。 提供了几种用于水合形成的骨组合物的装置。 还提供了水合形成的骨组合物的方法。

    Method and apparatus for preparing bone
    3.
    发明申请
    Method and apparatus for preparing bone 审中-公开
    骨的制备方法及装置

    公开(公告)号：US20060083769A1

    公开(公告)日：2006-04-20

    申请号：US10964950

    申请日：2004-10-14

    申请人： Mukesh Kumar ,  Ned Hamman ,  Michael Leach

    发明人： Mukesh Kumar ,  Ned Hamman ,  Michael Leach

    IPC分类号： A61K35/32 ,  A61F2/00

    CPC分类号： A61L27/365 ,  A61B17/8825 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/02

    摘要： Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Apparatus are provided comprising a retaining tube and a hydrating tube. Methods of hydrating a formed bone composition are also provided.

    摘要翻译： 用于施用于人或动物受试者的骨表面的成形组合物，包括：骨材料; 以及包含变性软化骨的载体，其中所述组合物形成适于施用于骨的形状。 提供用于制备用于施用于人或动物对象的骨表面的成形组合物的方法包括混合脱矿质骨和水; 加热混合物形成载体; 将载体与骨混合以形成可成型组合物; 并模塑可模制组合物以产生形成的组合物。 提供了包括保持管和水合管的装置。 还提供了水合形成的骨组合物的方法。

    Airflow control in floor mode for vehicle with multiple seating rows
    5.
    发明授权
    Airflow control in floor mode for vehicle with multiple seating rows 有权
    具有多个座位排的车辆的地面模式下的气流控制

    公开(公告)号：US09102215B2

    公开(公告)日：2015-08-11

    申请号：US13274729

    申请日：2011-10-17

    申请人： Mukesh Kumar ,  Paul B. Hoke ,  Martha E. Nefcy ,  David Wong

    发明人： Mukesh Kumar ,  Paul B. Hoke ,  Martha E. Nefcy ,  David Wong

    IPC分类号： B60H1/00 ,  F28F27/00 ,  F24F11/00

    CPC分类号： B60H1/00842 ,  B60H1/00021 ,  B60H1/00735 ,  B60H1/00742 ,  B60H2001/002 ,  F24F11/30 ,  F24F2110/00 ,  F24F2110/10 ,  F24F2120/10

    摘要： A comfort system is provided for a motor vehicle. A seat occupancy sensor determines whether a third row zone is occupied. At least one flow controller is provided in the floor duct for controllably supplying the conditioned airflow to at least the third row outlet. If the third row zone is occupied, then a second row outlet and the third row outlet are turned on to supply a conditioned airflow to a front seat zone, a second row zone, and the third row zone. If the third row zone is not occupied, then the third row outlet is closed off. If the second row zone is not occupied, then the second and third row outlets are closed off. If occupied, then the second row outlet is turned on until a desired comfort level is achieved in the second row zone.

    摘要翻译： 为汽车提供舒适系统。 座椅占用传感器确定第三行区域是否被占用。 至少一个流量控制器设置在地板管道中，用于可控地将经调节的气流提供给至少第三排出口。 如果第三排区域被占用，则第二排出口和第三排出口被打开以向前排座位区域，第二排区域和第三行区域提供经调节的气流。 如果第三排区域未被占用，则第三行出口被关闭。 如果第二行区域未被占用，则第二和第三行出口被关闭。 如果被占用，则第二排出口被打开，直到在第二行区域中达到期望的舒适度。

    Air ducts formed in automotive structural members
    6.
    发明授权
    Air ducts formed in automotive structural members 有权
    在汽车结构件中形成的空气管道

    公开(公告)号：US08641134B2

    公开(公告)日：2014-02-04

    申请号：US13437423

    申请日：2012-04-02

    申请人： Robert S. Sawyer ,  Mukesh Kumar ,  Martha E. Nefcy

    发明人： Robert S. Sawyer ,  Mukesh Kumar ,  Martha E. Nefcy

    IPC分类号： B60H1/24

    CPC分类号： B60H1/00564 ,  B60H1/245 ,  B60H1/246

    摘要： An air duct for an automotive vehicle is blow molded with an elongated, hollow structural member to be used as a portion of a body of the vehicle. The structural member has an inner wall defining an elongated cavity communicating with first and second access holes at respective longitudinal positions along the structural member. A parison comprised of a thermally insulating material is inserted into the internal cavity. A source of inflation gas is connected to a mouth portion or the parison. The parison is heated and inflated within the internal cavity to an expanded shape to form the air duct disposed against the inner wall and spanning the first and second access holes. The air duct at one of the access holes is configured as an air inlet. The air duct at the other one of the access holes is configured as an air outlet.

    摘要翻译： 用于机动车辆的空气管道是吹塑成型的，具有细长的中空结构件，用作车身的一部分。 结构构件具有限定在沿着结构构件的各个纵向位置处与第一和第二进入孔连通的细长腔的内壁。 将由隔热材料构成的型坯插入内部空腔。 膨胀气体源连接到口部或型坯。 型坯在内腔内被加热膨胀成扩张形状，以形成靠在内壁上并横跨第一和第二进入孔的空气通道。 一个进入孔的空气管道被构造为空气入口。 在另一个进入孔的空气管道被配置为空气出口。

    Air Ducts Formed in Automotive Structural Members
    7.
    发明申请
    Air Ducts Formed in Automotive Structural Members 有权
    空气管道组成汽车结构件

    公开(公告)号：US20130257106A1

    公开(公告)日：2013-10-03

    申请号：US13437423

    申请日：2012-04-02

    申请人： Robert S. Sawyer ,  Mukesh Kumar ,  Martha E. Nefcy

    发明人： Robert S. Sawyer ,  Mukesh Kumar ,  Martha E. Nefcy

    IPC分类号： B60H1/26 ,  B29C49/22

    CPC分类号： B60H1/00564 ,  B60H1/245 ,  B60H1/246

    摘要： An air duct for an automotive vehicle is blow molded with an elongated, hollow structural member to be used as a portion of a body of the vehicle. The structural member has an inner wall defining an elongated cavity communicating with first and second access holes at respective longitudinal positions along the structural member. A parison comprised of a thermally insulating material is inserted into the internal cavity. A source of inflation gas is connected to a mouth portion or the parison. The parison is heated and inflated within the internal cavity to an expanded shape to form the air duct disposed against the inner wall and spanning the first and second access holes. The air duct at one of the access holes is configured as an air inlet. The air duct at the other one of the access holes is configured as an air outlet.

    摘要翻译： 用于机动车辆的空气管道是吹塑成型的，具有细长的中空结构件，用作车身的一部分。 结构构件具有限定在沿着结构构件的各个纵向位置处与第一和第二进入孔连通的细长腔的内壁。 将由隔热材料构成的型坯插入内部空腔。 膨胀气体源连接到口部或型坯。 型坯在内腔内被加热膨胀成扩张形状，以形成靠在内壁上并横跨第一和第二进入孔的空气通道。 一个进入孔的空气管道被构造为空气入口。 在另一个进入孔的空气管道被配置为空气出口。

    Modular Junction Seal Of An Orthopedic Implant
    8.
    发明申请
    Modular Junction Seal Of An Orthopedic Implant 有权
    矫形植入物的模块接头密封

    公开(公告)号：US20130204389A1

    公开(公告)日：2013-08-08

    申请号：US13366510

    申请日：2012-02-06

    申请人： Mukesh Kumar ,  Robert M. Ronk ,  Daniel E. Williamson

    发明人： Mukesh Kumar ,  Robert M. Ronk ,  Daniel E. Williamson

    IPC分类号： A61F2/32

    CPC分类号： A61F2/3609 ,  A61F2002/30332 ,  A61F2002/30589 ,  A61F2002/30682 ,  A61F2002/365

    摘要： A seal for preventing a bodily fluid from penetrating an orthopedic implant comprising a tapered section adapted to conformingly mate to a stem of a first implant component, and a collar section extending from and circumferentially surrounding a portion of the tapered section, the collar section adapted to mate to a base of a second implant component such that the tapered section and collar section define an opening therethrough configured to receive the first implant component.

    摘要翻译： 一种用于防止体液穿透整形外科植入物的密封件，包括适于与第一植入部件的杆顺从地配合的锥形部分，以及从锥形部分的一部分延伸并周向围绕锥形部分的颈环部分， 配合到第二植入部件的基部，使得锥形部分和凸缘部分限定通过其构造成接收第一植入部件的开口。

    DRUG DELIVERY AND DIAGNOSTIC SYSTEM FOR ORTHOPEDIC IMPLANTS
    9.
    发明申请
    DRUG DELIVERY AND DIAGNOSTIC SYSTEM FOR ORTHOPEDIC IMPLANTS 有权
    用于正交植入物的药物递送和诊断系统

    公开(公告)号：US20110218644A1

    公开(公告)日：2011-09-08

    申请号：US13039362

    申请日：2011-03-03

    申请人： Jason Meridew ,  Mukesh Kumar ,  Tayler E. Kreider

    发明人： Jason Meridew ,  Mukesh Kumar ,  Tayler E. Kreider

    IPC分类号： A61M25/04 ,  A61F2/36

    CPC分类号： A61M5/14 ,  A61F2/34 ,  A61F2/3662 ,  A61F2/389 ,  A61F2002/3068 ,  A61F2002/368 ,  A61F2002/3694 ,  A61M5/14276 ,  A61M39/0208 ,  A61M2205/3523 ,  A61M2210/086

    摘要： A drug delivery and diagnostic system can include an orthopedic implant having an outer attachment surface. A conduit can be coupled to the outer attachment surface. The conduit can have an inlet and a plurality of perforations formed along a length thereof. The conduit can be adapted to pass fluid between the inlet and the perforations. A subcutaneous port can be fluidly coupled to the inlet and be adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.

    摘要翻译： 药物递送和诊断系统可以包括具有外部附接表面的矫形植入物。 管道可以联接到外部附接表面。 导管可以具有沿其长度形成的入口和多个穿孔。 导管可适于在入口和穿孔之间传递流体。 皮下端口可以流体地联接到入口，并且适于沿着导管和通过整形外科植入物的外部附接表面的穿孔穿过入口传送流体。

    COMPOSITIONS COMPRISING ANTI-ICAM-1 ANTIBODIES
    10.
    发明申请
    COMPOSITIONS COMPRISING ANTI-ICAM-1 ANTIBODIES 审中-公开
    包含抗ICAM-1抗体的组合物

    公开(公告)号：US20110052601A1

    公开(公告)日：2011-03-03

    申请号：US12390246

    申请日：2009-02-20

    申请人： Shyam S. Mohapatra ,  Aruna Behera ,  Hiroto Matsuse ,  Mukesh Kumar

    发明人： Shyam S. Mohapatra ,  Aruna Behera ,  Hiroto Matsuse ,  Mukesh Kumar

    IPC分类号： A61K39/42 ,  A61P11/00 ,  A61P31/12

    CPC分类号： C12N15/1138 ,  C12N15/111 ,  C12N2310/11 ,  C12N2320/32

    摘要： There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding.

    摘要翻译： 提供了一种通过施用有效量的用于调节ICAM-1表达的试剂来预防呼吸道感染的方法。 还提供了用于预防呼吸道感染的组合物，包括调节ICAM表达的药剂。 通过施用有效量的妨碍RSV与ICAM-1的结合的试剂来预防RSV感染的方法。 还提供了通过施用有效量的下调ICAM-1的表达的试剂，从而降低RSV与ICAM-1的结合来预防RSV感染的方法。 提供了通过施用有效量的用于下调ICAM-1表达的试剂来治疗RSV感染的方法。 提供了通过施用有效量的阻断ICAM结合位点的试剂阻断RSV-ICAM-1相互作用的方法。 还提供了用于阻断RSV-ICAM-1相互作用的化合物，其包括用于阻断结合的ICAM位点的试剂。