摘要:
Provided herein are methods of treating hypercalcemia in a subject, comprising administering to the subject a therapeutically effective amount of a composition that decreases the expression level and/or activity of GPR64. Compositions comprising the therapeutic agents and methods of screening for agonists and inhibitors of GPR64 are also provided. Compositions and methods for treating primary hyperparathyroidism, secondary hyperparathyroidism, hypoparathyroidism, and osteoporosis without hyperparathyroidism are also provided.
摘要:
A bilateral upper limb exercise device (10) for exercising a user's arms comprising a central mounting structure (12) that is mountable to a fixed surface or structure (15), left and right limb supports (14a,14b) for supporting the forearm and/or hand of a respective arm of the user, and a pair of articulated linkage arms (22a,22b) that are pivotably coupled to opposite sides of the central mounting structure (12) and which are arranged to support a respective limb support (14a,14b) for movement in at least two degrees of freedom in a two-dimensional (2D) movement plane. A mirroring mechanism is also operatively coupled to the articulated linkage arms (22a,22b) such that movement of the opposing limb support relative to a central line of symmetry of the device.
摘要:
A method is disclosed to monitor the status of devices disposed in a computing system. The method provides a computing device comprising a plurality of devices, and a system monitoring algorithm comprising a monitoring interval and a device status for each of (N) devices disposed in the computing device, where those (N) devices comprise a portion or all of the plurality of devices. The method sets for each value of (i), the (i)th monitoring interval and the (i)th device status, where the (i)th device status is selected from the group comprising active and inactive; where (i) is greater than or equal to 1 and less than or equal to (N). As long as the (i)th device status is set to active, the method monitors the status of the (i)th device at the expiration of each (i)th monitoring interval. On the other hand, as long as the (i)th device status is set to inactive, the method does not monitoring the status of the (i)th device at the expiration of each (i)th monitoring interval.
摘要:
The present invention relates to the use of extra particulate additives in selected chemically processed toner compositions for use in an image forming apparatus. The extra particulate additive may have a controlled aspect ratio and be combined with the chemically processed toner. The chemically processed toner may provide toner particles having controlled diameters and rheological properties that may be combined with a release agent. The release agent may also be selected with respect to, e.g., concentration and/or mean domain size within the toner particles including considerations of coating chemistry and/or DSC melting behavior.
摘要:
The present disclosure relates to methods for increasing heme uptake in a Gram-negative bacterium comprising expressing at least one transgenic heme transport gene in the bacterium. The present disclosure also relates to heme protein production cells comprising at least one transgenic heme transport gene and a heme protein gene and plasmids comprising one or more heme transport genes and a promoter operable to promote expression of the genes by iron depletion or by the addition of an inducer molecule. The present disclosure also relates to systems for heme protein production.
摘要:
A personal ballistic protective device having a first layer comprised of ballistic material and a second layer comprised of buoyant material. The second layer preferably has a density sufficient to counteract a density of at least the first layer of ballistic material such that the first layer and the second layer have a combined density substantially equal to or less than the density of water. A method of counteracting negative buoyancy in a personal protective device is also disclosed.
摘要:
Toner is rounded by vigorously mixing less than about 5 percent by weight of particulate silica to the total weight of a starting toner in a closed, recirculating air system. The starting toner contains at least about 4.5 percent by weight of the starting toner of a wax and additionally contains at least 5 percent by weight of the starting toner of a softening agent. The temperature during the mixing is no more than 13 degrees C. above the onset of the glass transition temperature of the starting toner. The final toner comprises rounded starting toner having particulate silica embedded during the mixing process.
摘要:
A portable container for holding office products and documents includes a rigid structural portion capable of holding hanging folders in a cascading configuration and a cover portion attached to the rigid structural portion. The cover portion may be made from a pliable material, to make the container lightweight and aesthetically pleasing. The container may include a wire insert for supporting hanging file folders.
摘要:
A radar system embeds information into the radar picture data for display on any display device. The radar receiver communicates weather data to a signal processor which generates a weather array. An I/O processor transmits data in the weather array to a display device via a picture bus. Alphanumeric data which is to be embedded into or combined with the weather array is stored in a message array. Font information for each alphanumeric character is stored in a font array. The message array and the font array are combined and translated into a text array which corresponds to the weather array. Prior to transmitting each radial of data to the display device, the I/O processor copies the appropriate radial data from the text array to the weather array thereby causing the desired alphanumeric characters to be displayed on the display device.