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12 条记录 (耗时 0.018 秒)

    Field effect transistor with independently biased gates
    1.
    发明申请
    Field effect transistor with independently biased gates 失效
    具有独立偏置栅极的场效应晶体管

    公开(公告)号：US20070241368A1

    公开(公告)日：2007-10-18

    申请号：US11406838

    申请日：2006-04-18

    申请人： Samson Mil'shtein ,  John Palma

    发明人： Samson Mil'shtein ,  John Palma

    IPC分类号： H01L31/00

    CPC分类号： H01L29/7783 ,  H01L29/42316

    摘要： A field effect transistor (FET) having at least two independently biased gates can provide uniform electric field in the channel region of the FET. The same AC voltage may be applied to each gate for modulating the FET. One of the gates is positioned closer to the channel region than the other gate. Such a FET allows tailoring the electric field in the channel region of the FET so that it is substantially uniform. The FET exhibits desirable performance characteristics, including having a constant transconductance.

    摘要翻译： 具有至少两个独立偏置栅极的场效应晶体管（FET）可以在FET的沟道区域中提供均匀的电场。 可以向每个栅极施加相同的AC电压以调制FET。 一个栅极位于比另一个栅极更靠近沟道区域的位置。 这样的FET允许调整FET的沟道区域中的电场，使得其基本均匀。 FET具有期望的性能特征，包括具有恒定的跨导。

    Gene expression profiling in colon cancers
    2.
    发明申请
    Gene expression profiling in colon cancers 审中-公开
    基因表达谱在结肠癌

    公开(公告)号：US20080014579A1

    公开(公告)日：2008-01-17

    申请号：US10777860

    申请日：2004-02-11

    申请人： Chunmei Liu ,  John Palma ,  Janet A. Warrington

    发明人： Chunmei Liu ,  John Palma ,  Janet A. Warrington

    IPC分类号： C12Q1/68 ,  C40B20/04 ,  C40B30/00

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136

    摘要： Sets of genetic markers for specific tumor classes are described, as well as methods of identifying a biological sample based on these markers. Genes that are differentially expressed between different stages of colorectal tumors are identified. Genes that are differentially expressed between tumors that have metastasized to the regional lymph nodes and tumors that have not metastasized to the regional lymph nodes are identified. Changes in gene expression pattern between two samples or between a sample and a control may be used to determine tumor stage. Also described are diagnostic, prognostic, and therapeutic screening uses for these markers, as well as oligonucleotide arrays comprising these markers.

    摘要翻译： 描述了用于特定肿瘤类别的遗传标记的集合，以及基于这些标记鉴定生物样品的方法。 鉴定在不同阶段的结肠直肠肿瘤之间差异表达的基因。 鉴定了转移到区域淋巴结的肿瘤和尚未转移到区域性淋巴结的肿瘤之间差异表达的基因。 可以使用两个样品之间或样品与对照之间的基因表达模式的变化来确定肿瘤阶段。 还描述了这些标记物的诊断，预后和治疗筛选用途，以及包含这些标记的寡核苷酸阵列。

    Disposable postage stamp marker
    3.
    发明授权
    Disposable postage stamp marker 失效
    一次性邮票标记

    公开(公告)号：US5271322A

    公开(公告)日：1993-12-21

    申请号：US959421

    申请日：1992-10-13

    申请人： John Palma

    发明人： John Palma

    IPC分类号： B41K1/00 ,  G07B17/00 ,  B41K1/42

    CPC分类号： B41K1/00 ,  G07B17/00193 ,  G07B17/00508 ,  G07B2017/00217 ,  G07B2017/00233 ,  G07B2017/00548

    摘要： A disposable postage stamp marker is provided which consists of a frame and a device carried within the frame, for making a predetermined amount of visible impressions of small official government seals on mail to show that postage has been paid for the mail. An apparatus is carried within the frame and is coupled to the visible impressions making a device for enumerating the predetermined amount of visible impressions that can be made.

    摘要翻译： 提供了一个一次性邮票标记，其由框架和在框架内携带的装置组成，用于在邮件上形成预定量的小官方政府印章的可见印象，以显示已经为邮件支付了邮费。 在框架内携带一个装置，并且耦合到可见的印象，形成用于枚举可以进行的预定量的可见印象的装置。

    Methods of analysis of degraded nucleic acid samples
    7.
    发明申请
    Methods of analysis of degraded nucleic acid samples 失效
    降解核酸样品的分析方法

    公开(公告)号：US20050272080A1

    公开(公告)日：2005-12-08

    申请号：US11121849

    申请日：2005-05-03

    申请人： John Palma ,  Eric Schell ,  Alan Williams

    发明人： John Palma ,  Eric Schell ,  Alan Williams

    IPC分类号： C12M1/34 ,  C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/166

    摘要： The invention provides arrays for analysis of compromised nucleic acid samples, for example, nucleic acids obtained from formalin fixed paraffin embedded samples and methods to analyzed these compromised samples. Arrays are disclosed in which the probe selection region used to select probes for the array is the 300 bases of the target MRNA that are immediately upstream of the start of the poly(A) tail of the mRNA. The probes selected for the array are more biased toward the 3′ end of the mRNA than other arrays that are currently available.

    摘要翻译： 本发明提供用于分析受损核酸样品的阵列，例如从福尔马林固定石蜡包埋样品获得的核酸和分析这些受损样品的方法。 公开了阵列，其中用于选择阵列的探针的探针选择区是目标MRNA的300个碱基，其紧邻mRNA的poly（A）尾的起始位置的上游。 针对阵列选择的探针比目前可用的其他阵列更偏向mRNA的3'末端。