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1.发明申请公开(公告)号：US20140357903A1
公开(公告)日：2014-12-04
申请号：US14458320
申请日：2014-08-13
申请人： Alan DYKE , Damian Mark GRAINGER , Jonathan Alan MEDLOCK , Hans Guenter NEDDEN , Jacques Jean Marie LE PAIH , Stephen James ROSEBLADE , Andreas SEGER , Vilvanathan SIVAKUMAR , Antonio ZANOTTI-GEROSA
发明人： Alan DYKE , Damian Mark GRAINGER , Jonathan Alan MEDLOCK , Hans Guenter NEDDEN , Jacques Jean Marie LE PAIH , Stephen James ROSEBLADE , Andreas SEGER , Vilvanathan SIVAKUMAR , Antonio ZANOTTI-GEROSA
IPC分类号： C07C29/145 , B01J31/22
CPC分类号： B01J31/1805 , B01J31/2295 , B01J2231/643 , B01J2531/0238 , B01J2531/821 , C07C29/145 , C07C311/05 , C07C311/07 , C07C311/18 , C07C311/20 , C07C2523/70 , C07C2531/18 , C07C2601/14 , C07C2601/16 , C07F15/0046 , C07F15/0053 , C07C33/22
摘要： The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
摘要翻译： 本发明涉及一种氢化含有碳 - 杂原子双键的底物的方法，该方法包括在氢化催化剂存在下使底物与氢气反应的步骤，其中氢化催化剂是式（I ）：R1-10，A和Hal如说明书中所定义。 本发明还提供制备式（I）的络合物及其中间体的方法。
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2.发明申请Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis 审中-公开磺酰化二苯乙二胺，其制备方法及其在转移氢化催化中的应用公开(公告)号：US20090326274A1
公开(公告)日：2009-12-31
申请号：US12493043
申请日：2009-06-26
IPC分类号： C07C45/61 , C07C211/01 , B01J31/02
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译： 描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或 烷氧基取代基。 手性二胺可用于制备适用于转移氢化反应的催化剂。
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公开(公告)号：US20120123142A1
公开(公告)日：2012-05-17
申请号：US13257166
申请日：2010-03-17
申请人： Alan Dyke , Damian Mark Grainger , Jonathan Alan Medlock , Hans Guenter Nedden , Jacques Jean Marie Le Paih , Stephen James Roseblade , Andreas Seger , Vilvanathan Sivakumar , Antonio Zanotti-Gerosa
发明人： Alan Dyke , Damian Mark Grainger , Jonathan Alan Medlock , Hans Guenter Nedden , Jacques Jean Marie Le Paih , Stephen James Roseblade , Andreas Seger , Vilvanathan Sivakumar , Antonio Zanotti-Gerosa
IPC分类号： C07F15/00 , C07C303/40 , C07C311/20 , C07C311/07 , C07C311/18 , C07C29/145 , C07C311/05
CPC分类号： B01J31/1805 , B01J31/2295 , B01J2231/643 , B01J2531/0238 , B01J2531/821 , C07C29/145 , C07C311/05 , C07C311/07 , C07C311/18 , C07C311/20 , C07C2523/70 , C07C2531/18 , C07C2601/14 , C07C2601/16 , C07F15/0046 , C07F15/0053 , C07C33/22
摘要： The present invention relates to a process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
摘要翻译： 本发明涉及用于氢化包含碳 - 杂原子双键的底物的方法，该方法包括在氢化催化剂存在下使底物与氢气反应的步骤，其中氢化催化剂是式（I ）：R1-10，A和Hal如说明书中所定义。 本发明还提供制备式（I）的络合物及其中间体的方法。
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4.发明申请Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis 有权磺酰化二苯乙二胺，其制备方法及其在转移氢化催化中的应用公开(公告)号：US20120077973A1
公开(公告)日：2012-03-29
申请号：US13313889
申请日：2011-12-07
IPC分类号： C07D223/18 , B01J31/02 , C07C311/10
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译： 描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，并且X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或 烷氧基取代基。 手性二胺可用于制备适用于转移氢化反应的催化剂。
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公开(公告)号：US07601867B2
公开(公告)日：2009-10-13
申请号：US11719478
申请日：2005-11-01
IPC分类号： C07C311/21 , C07C311/16 , C07C311/03 , C07C303/38
摘要： A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
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6.发明授权Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis 有权磺酰化二苯基乙二胺，其制备方法和用于转移氢化催化公开(公告)号：US08859815B2
公开(公告)日：2014-10-14
申请号：US13313889
申请日：2011-12-07
IPC分类号： C07C311/13 , C07C311/14 , C07C311/16 , C07C33/20 , C07C33/22 , C07C33/46 , C07C303/38 , B01J31/18 , C07C29/143 , C07C311/18
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译： 描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或 烷氧基取代基。 手性二胺可用于制备适用于转移氢化反应的催化剂。
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7.发明授权公开(公告)号：US09416100B2
公开(公告)日：2016-08-16
申请号：US13257166
申请日：2010-03-17
申请人： Alan Dyke , Damian Mark Grainger , Jonathan Alan Medlock , Hans Guenter Nedden , Jacques Jean Marie Le Paih , Stephen James Roseblade , Andreas Seger , Vilvanathan Sivakumar , Antonio Zanotti-Gerosa
发明人： Alan Dyke , Damian Mark Grainger , Jonathan Alan Medlock , Hans Guenter Nedden , Jacques Jean Marie Le Paih , Stephen James Roseblade , Andreas Seger , Vilvanathan Sivakumar , Antonio Zanotti-Gerosa
IPC分类号： C07C311/05 , C07C311/07 , C07C311/18 , C07C311/20 , C07F15/00 , B01J31/18 , B01J31/22 , C07C29/145
CPC分类号： B01J31/1805 , B01J31/2295 , B01J2231/643 , B01J2531/0238 , B01J2531/821 , C07C29/145 , C07C311/05 , C07C311/07 , C07C311/18 , C07C311/20 , C07C2523/70 , C07C2531/18 , C07C2601/14 , C07C2601/16 , C07F15/0046 , C07F15/0053 , C07C33/22
摘要： The present invention relates to a process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
摘要翻译： 本发明涉及用于氢化包含碳 - 杂原子双键的底物的方法，该方法包括在氢化催化剂存在下使底物与氢气反应的步骤，其中氢化催化剂是式（I ）：R1-10，A和Hal如说明书中所定义。 本发明还提供制备式（I）的络合物及其中间体的方法。
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公开(公告)号：US08680278B2
公开(公告)日：2014-03-25
申请号：US12290438
申请日：2008-10-30
申请人： William A. Kinney , Christopher A. Teleha , Shyamali Ghosh , Bruce E. Maryanoff , Gabriela Grasa , Antonio Zanotti-Gerosa , Jonathan Alan Medlock
发明人： William A. Kinney , Christopher A. Teleha , Shyamali Ghosh , Bruce E. Maryanoff , Gabriela Grasa , Antonio Zanotti-Gerosa , Jonathan Alan Medlock
IPC分类号： C07D215/00 , C07D417/02 , C07D401/00
CPC分类号： C07D401/06 , B01J31/2213 , B01J31/2409 , B01J31/2495 , B01J2231/645 , B01J2531/0263 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07D405/14 , C07D471/04
摘要： The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
摘要翻译： 本发明涉及对映选择性制备取代的哌啶链烷酸整联蛋白拮抗剂化合物的方法。
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9.发明授权Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis 有权磺酰化二苯基乙二胺，其制备方法和用于转移氢化催化公开(公告)号：US07667075B2
公开(公告)日：2010-02-23
申请号：US11719478
申请日：2005-11-01
IPC分类号： C07C311/21 , C07C311/16 , C07C311/03 , C07C303/38
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译： 描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或 烷氧基取代基。 手性二胺可用于制备适用于转移氢化反应的催化剂。
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