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公开(公告)号：US08680278B2
公开(公告)日：2014-03-25
申请号：US12290438
申请日：2008-10-30
申请人： William A. Kinney , Christopher A. Teleha , Shyamali Ghosh , Bruce E. Maryanoff , Gabriela Grasa , Antonio Zanotti-Gerosa , Jonathan Alan Medlock
发明人： William A. Kinney , Christopher A. Teleha , Shyamali Ghosh , Bruce E. Maryanoff , Gabriela Grasa , Antonio Zanotti-Gerosa , Jonathan Alan Medlock
IPC分类号： C07D215/00 , C07D417/02 , C07D401/00
CPC分类号： C07D401/06 , B01J31/2213 , B01J31/2409 , B01J31/2495 , B01J2231/645 , B01J2531/0263 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07D405/14 , C07D471/04
摘要： The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
摘要翻译： 本发明涉及对映选择性制备取代的哌啶链烷酸整联蛋白拮抗剂化合物的方法。
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公开(公告)号：US20090124804A1
公开(公告)日：2009-05-14
申请号：US12290438
申请日：2008-10-30
IPC分类号： C07D401/14 , C07D401/02
CPC分类号： C07D401/06 , B01J31/2213 , B01J31/2409 , B01J31/2495 , B01J2231/645 , B01J2531/0263 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07D405/14 , C07D471/04
摘要： The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
摘要翻译： 本发明涉及对映选择性制备取代的哌啶链烷酸整联蛋白拮抗剂化合物的方法。
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公开(公告)号：US09079896B2
公开(公告)日：2015-07-14
申请号：US12533257
申请日：2009-07-31
IPC分类号： C07D487/12 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters and prodrugs thereof, pharmaceutical compositions containing compounds of formula (I) and the use of said compounds and compositions as urotensin II receptor antagonists.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，酯和前药，含有式（I）化合物的药物组合物以及所述化合物和组合物作为尿素转运蛋白II受体拮抗剂的用途。
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公开(公告)号：US20110136824A1
公开(公告)日：2011-06-09
申请号：US13026549
申请日：2011-02-14
申请人： Bruce E. Maryanoff , William A. Kinney , Edward C. Lawson , Diane K. Luci , Nikolay Marchenko , Sergey Sviridov , Shyamali Ghosh
发明人： Bruce E. Maryanoff , William A. Kinney , Edward C. Lawson , Diane K. Luci , Nikolay Marchenko , Sergey Sviridov , Shyamali Ghosh
IPC分类号： A61K31/496 , C07D403/10 , C07D209/48 , A61K31/4035 , C07D403/14 , A61P9/00 , A61P13/12 , A61P1/18 , A61P25/28
CPC分类号： C07D209/48 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/14 , C07D487/08 , C07D513/04
摘要： The invention is directed to Urotensin II antagonists. More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating Urotensin-II mediated disorders. Pharmaceutical and veterinary compositions and methods of treating cardiovascular disorders and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及尿激素II拮抗剂。 更具体地，本发明涉及某些新化合物，其制备方法，组合物，中间体及其衍生物以及用于治疗促肾上腺素II介导的病症的方法。 还描述了使用本发明化合物治疗心血管疾病和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US08536174B2
公开(公告)日：2013-09-17
申请号：US13459708
申请日：2012-04-30
IPC分类号： A61K31/4995 , C07D487/08
CPC分类号： C07D209/48 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/14 , C07D487/08 , C07D513/04
摘要： The invention is directed to Urotensin II antagonists. More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating Urotensin-II mediated disorders. Pharmaceutical and veterinary compositions and methods of treating cardiovascular disorders and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及尿激素II拮抗剂。 更具体地，本发明涉及某些新化合物，其制备方法，组合物，中间体及其衍生物以及用于治疗促肾上腺素II介导的病症的方法。 还描述了使用本发明化合物治疗心血管疾病和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US20100029616A1
公开(公告)日：2010-02-04
申请号：US12533257
申请日：2009-07-31
IPC分类号： A61K31/496 , C07D471/04 , C07D487/04 , A61K31/55 , A61P9/00 , A61P9/12 , A61P9/10 , A61P3/10 , A61P11/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters and prodrugs thereof, pharmaceutical compositions containing compounds of formula (I) and the use of said compounds and compositions as urotensin II receptor antagonists.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，酯和前药，含有式（I）化合物的药物组合物以及所述化合物和组合物作为尿素转运蛋白II受体拮抗剂的用途。
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公开(公告)号：US07915260B2
公开(公告)日：2011-03-29
申请号：US11651848
申请日：2007-01-10
申请人： Bruce E. Maryanoff , William A. Kinney , Edward C. Lawson , Diane K. Luci , Nikolay Marchenko , Sergey Sviridov , Shyamali Ghosh
发明人： Bruce E. Maryanoff , William A. Kinney , Edward C. Lawson , Diane K. Luci , Nikolay Marchenko , Sergey Sviridov , Shyamali Ghosh
IPC分类号： A61K31/501 , A61K31/496 , C07D209/48 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/14 , C07D417/12 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4035 , A61K31/551 , C07D451/02 , C07D487/08
CPC分类号： C07D209/48 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/14 , C07D487/08 , C07D513/04
摘要： The invention is directed to Urotensin II antagonists. More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating Urotensin-II mediated disorders. Pharmaceutical and veterinary compositions and methods of treating cardiovascular disorders and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及尿激素II拮抗剂。 更具体地，本发明涉及某些新化合物，其制备方法，组合物，中间体及其衍生物以及用于治疗促肾上腺素II介导的病症的方法。 还描述了使用本发明化合物治疗心血管疾病和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US20120214817A1
公开(公告)日：2012-08-23
申请号：US13459708
申请日：2012-04-30
申请人： Bruce E Maryanoff , William A. Kinney , Edward C. Lawson , Diane K. Luci , Nikolay Marchenko , Sergey Sviridov , Shyamali Ghosh
发明人： Bruce E Maryanoff , William A. Kinney , Edward C. Lawson , Diane K. Luci , Nikolay Marchenko , Sergey Sviridov , Shyamali Ghosh
IPC分类号： A61K31/4995 , A61K31/496 , A61K31/439 , A61K31/454 , A61K31/4035 , C07D403/14 , C07D471/08 , C07D403/10 , C07D401/10 , C07D209/48 , C07D409/14 , A61P9/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P1/12 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/08 , A61P25/24 , A61P25/06 , A61P25/18 , A61P25/22 , A61P21/00 , A61K31/506
CPC分类号： C07D209/48 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/14 , C07D487/08 , C07D513/04
摘要： The invention is directed to Urotensin II antagonists. More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating Urotensin-II mediated disorders. Pharmaceutical and veterinary compositions and methods of treating cardiovascular disorders and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及尿激素II拮抗剂。 更具体地，本发明涉及某些新化合物，其制备方法，组合物，中间体及其衍生物以及用于治疗促肾上腺素II介导的病症的方法。 还描述了使用本发明化合物治疗心血管疾病和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US08193191B2
公开(公告)日：2012-06-05
申请号：US13026549
申请日：2011-02-14
IPC分类号： C07D487/08 , A61K31/4995
CPC分类号： C07D209/48 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/14 , C07D487/08 , C07D513/04
摘要： The invention is directed to Urotensin II antagonists. More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating Urotensin-II mediated disorders. Pharmaceutical and veterinary compositions and methods of treating cardiovascular disorders and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及尿激素II拮抗剂。 更具体地，本发明涉及某些新化合物，其制备方法，组合物，中间体及其衍生物以及用于治疗促肾上腺素II介导的病症的方法。 还描述了使用本发明化合物治疗心血管疾病和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US08110683B2
公开(公告)日：2012-02-07
申请号：US12975900
申请日：2010-12-22
申请人： Bart De Corte , William A. Kinney , Bruce E. Maryanoff , Shyamali Ghosh , Li Liu
发明人： Bart De Corte , William A. Kinney , Bruce E. Maryanoff , Shyamali Ghosh , Li Liu
IPC分类号： C07D239/06
CPC分类号： C07D471/04 , A61K31/4523 , A61K45/06 , A61K51/0455 , A61K51/0459 , C07D401/12 , C07D401/14 , C07D405/14 , Y02P20/582 , A61K2300/00
摘要： The invention is directed to piperidinyl compounds that selectively bind integrin receptors and methods for treating an integrin mediated disorder.
摘要翻译： 本发明涉及选择性结合整联蛋白受体的哌啶基化合物和用于治疗整联蛋白介导的病症的方法。
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