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公开(公告)号:US09017974B2
公开(公告)日:2015-04-28
申请号:US14125035
申请日:2012-05-25
申请人: Gang Zheng , Jonathan Lovell
发明人: Gang Zheng , Jonathan Lovell
IPC分类号: C12P17/18 , B01J13/02 , A61K31/704 , C07F9/6561 , C07F9/10 , C09B67/02 , A61K41/00 , A61K47/48 , A61K8/55 , A61Q19/00 , A61K8/14 , C09B69/10
CPC分类号: C12P17/182 , A61K8/14 , A61K8/553 , A61K31/704 , A61K41/0071 , A61K47/544 , A61K2800/10 , A61Q19/00 , B01J13/02 , C07F9/106 , C07F9/6561 , C09B67/0097 , C09B69/108
摘要: There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.
摘要翻译: 本文描述了包含卟啉 - 磷脂共轭物双层的纳米囊。 每个卟啉 - 磷脂缀合物包含一个卟啉,卟啉衍生物或卟啉类似物,其共价连接到一个磷脂的sn-1或sn-2位置之一的脂质侧链。 此外,纳米囊具有定义的sn-1:sn-2卟啉 - 磷脂缀合物的区域异构体比例。
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公开(公告)号:US20140127763A1
公开(公告)日:2014-05-08
申请号:US14125035
申请日:2012-05-25
申请人: Gang Zheng , Jonathan Lovell
发明人: Gang Zheng , Jonathan Lovell
IPC分类号: C12P17/18 , C07F9/6561
CPC分类号: C12P17/182 , A61K8/14 , A61K8/553 , A61K31/704 , A61K41/0071 , A61K47/544 , A61K2800/10 , A61Q19/00 , B01J13/02 , C07F9/106 , C07F9/6561 , C09B67/0097 , C09B69/108
摘要: There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.
摘要翻译: 本文描述了包含卟啉 - 磷脂共轭物双层的纳米囊。 每个卟啉 - 磷脂缀合物包含一个卟啉,卟啉衍生物或卟啉类似物,其共价连接到一个磷脂的sn-1或sn-2位置之一的脂质侧链。 此外,纳米囊具有定义的sn-1:sn-2卟啉 - 磷脂缀合物的区域异构体比例。
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