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![SUBSTITUTED 5H-PYRIMIDO[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM](/abs-image/US/2011/01/27/US20110021511A1/abs.jpg.150x150.jpg)
1.发明申请SUBSTITUTED 5H-PYRIMIDO[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM 失效取代的5H-吡啶并[5,4-B]吲哚，其生产方法及其用于治疗血液生成系统的非固体恶性肿瘤的用途公开(公告)号：US20110021511A1
公开(公告)日：2011-01-27
申请号：US12520480
申请日：2007-12-21
申请人： Claudia Reichelt , Alexander Schulze , Mohammed Daghish , Friedrich-Alexander Ludwig , Jochen Heinicke , Konrad Herrmann , Maj Schuster , Sven Letschert , Kenneth Mugridge , Joseph DeAngelo
发明人： Claudia Reichelt , Alexander Schulze , Mohammed Daghish , Friedrich-Alexander Ludwig , Jochen Heinicke , Konrad Herrmann , Maj Schuster , Sven Letschert , Kenneth Mugridge , Joseph DeAngelo
IPC分类号： C07D487/04 , A61P35/02 , A61K31/5377 , A61P35/04 , A61K31/496 , A61P35/00 , A61K31/541
CPC分类号： C07D487/04
摘要： The invention relates to compounds of general formula 1 to processes for the production thereof, to pharmaceutical preparations containing said compounds and/or physiologically compatible salts and/or solvates which can be produced therefrom as well as to the pharmaceutical use of said compounds, the salts or solvates thereof as inductors of apoptosis in the case of non-solid malignant tumors of the hematopoietic system, in particular in the case of leukemias and lymphomas, more particularly in the case of leukemic B lymphocytes.
摘要翻译： 本发明涉及通式1的化合物，其制备方法，含有所述化合物的药物制剂和/或可由其制备的生理上相容的盐和/或溶剂化物以及所述化合物的药物用途，所述盐 或在造血系统的非固体恶性肿瘤的情况下，特别是在白血病和淋巴瘤的情况下，更具体地在白血病B淋巴细胞的情况下，作为细胞凋亡的感应器。
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公开(公告)号：US08336365B2
公开(公告)日：2012-12-25
申请号：US13053420
申请日：2011-03-22
IPC分类号： G01M1/14
CPC分类号： G01N29/30 , G01N29/07 , G01N29/4427
摘要： Disclosed is a method and an NDT/NDI calibration process that automatically detects erroneous TOF readings by providing a predetermined time acceptance window. During the calibration process, TOF readings acquired by a UT device are validated to determine whether the TOF reading for the thin test block falls within the range of the predetermined time acceptance window. If the TOF reading for the thin block (T2) falls out of the predetermined time acceptance window, the operator is alerted of an error and to repeat the TOF test for the thin block.
摘要翻译： 公开了一种方法和NDT / NDI校准过程，其通过提供预定的时间接受窗口来自动检测错误的TOF读数。 在校准过程中，由UT器件获取的TOF读数被验证，以确定薄测试块的TOF读数是否落在预定时间接受窗口的范围内。 如果薄块（T2）的TOF读数落在预定时间接受窗口之外，则操作者被警告一个错误，并重复对该块的TOF测试。
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3.发明授权公开(公告)号：US08156784B2
公开(公告)日：2012-04-17
申请号：US12631065
申请日：2009-12-04
IPC分类号： G01B17/02
CPC分类号： G01B17/02 , G01N29/07 , G01N29/30 , G01N2291/02854 , G01S7/52004 , G01S15/101 , G01S15/88
摘要： A system and method for carrying out non-destructive testing and inspection of test objects to assess their structural integrity uses a calibration module configured to provide V-Path time of flight (TOF) correction data over a plurality of object thickness points, obtained from an object or objects having known thicknesses using the same physical probe as is used for the inspection measurements. When a probe launches acoustical waves into a test object and an instrument and a control system compute a time of flight value of the acoustical waves launched by the probe, the pre-obtained V-Path TOF correction data is used to correct the measured time of flight computed by the instrument.
摘要翻译： 用于对测试对象进行非破坏性测试和检查以评估其结构完整性的系统和方法使用校准模块，该校准模块被配置为在多个对象厚度点上从多个对象厚度点提供V-Path飞行时间（TOF）校正数据， 使用与用于检查测量的物理探针相同的物理探针具有已知厚度的物体或物体。 当探测器将探测声波发射到测试对象中并且仪器和控制系统计算由探测器发射的声波的飞行时间值时，预先获得的V-Path TOF校正数据用于校正测量时间 飞行计算仪器。
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4.发明申请SYSTEM AND METHOD FOR DERIVATION AND REAL-TIME APPLICATION OF ACOUSTIC V-PATH CORRECTION DATA 有权用于传播和实时应用声学V-PATH校正数据的系统和方法公开(公告)号：US20110132067A1
公开(公告)日：2011-06-09
申请号：US12631065
申请日：2009-12-04
IPC分类号： G01B17/02
CPC分类号： G01B17/02 , G01N29/07 , G01N29/30 , G01N2291/02854 , G01S7/52004 , G01S15/101 , G01S15/88
摘要： A system and method for carrying out non-destructive testing and inspection of test objects to assess their structural integrity uses a calibration module configured to provide V-Path time of flight (TOF) correction data over a plurality of object thickness points, obtained from an object or objects having known thicknesses using the same physical probe as is used for the inspection measurements. When a probe launches acoustical waves into a test object and an instrument and a control system compute a time of flight value of the acoustical waves launched by the probe, the pre-obtained V-Path TOF correction data is used to correct the measured time of flight computed by the instrument.
摘要翻译： 用于对测试对象进行非破坏性测试和检查以评估其结构完整性的系统和方法使用校准模块，该校准模块被配置为在多个对象厚度点上从多个对象厚度点提供V-Path飞行时间（TOF）校正数据， 使用与用于检查测量的物理探针相同的物理探针具有已知厚度的物体或物体。 当探测器将探测声波发射到测试对象中并且仪器和控制系统计算由探测器发射的声波的飞行时间值时，预先获得的V-Path TOF校正数据用于校正测量时间 飞行计算仪器。
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5.发明授权
公开(公告)号：US6020308A
公开(公告)日：2000-02-01
申请号：US126930
申请日：1998-07-31
IPC分类号： A61N5/02 , A61F7/00 , A61K31/00 , A61K31/195 , A61K31/198 , A61K31/4045 , A61K31/42 , A61K38/16 , A61K38/42 , A61K41/00 , A61K45/06 , A61P35/00 , A61P43/00 , A61K35/14
CPC分类号： A61K41/0052 , A61K31/00 , A61K31/195 , A61K31/198 , A61K31/4045 , A61K38/42 , Y10S514/832 , Y10S514/833 , Y10S514/929 , Y10S514/93
摘要： The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as as an adjunct to treatment of inappropriate tissue vascularization disorders.
摘要翻译： 本发明涉及NO活性抑制剂如一氧化氮清除剂或NO合成酶抑制剂作为治疗不适当组织血管化病症的辅助剂。
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公开(公告)号：US08013022B2
公开(公告)日：2011-09-06
申请号：US11796451
申请日：2007-04-27
申请人： Joseph DeAngelo , David Needham , Carroll Jones
发明人： Joseph DeAngelo , David Needham , Carroll Jones
CPC分类号： A61J1/10 , A01N1/02 , A01N1/0263 , A61M1/0209 , A61M1/0227 , A61M1/0272 , Y10S514/832 , Y10S514/833 , Y10S514/938 , Y10S514/939 , Y10S516/923 , Y10T428/2982
摘要： Disclosed is a multi-compartment medical device useful in the storage, processing and extended shelf life of perishable products, especially pharmaceutical, food and biological products. Particular biological materials processed according to the present methods are human blood and blood products (RBCs). Also disclosed are processes for preserving food, pharmaceutical and biological products for long-term storage and extended shelf life employing a process that reduces the hydration level of the material to less than native hydration levels of the specific product. The invention further provides stabilized biological products, such as in the form of glassified beads, prepared using a two-phase system according to the described processes that may be rehydrated and prepared for clinical use, and having essentially no loss of biological and/or pharmacological activity.
摘要翻译： 公开了一种多室医疗装置，其用于易腐食品，特别是制药，食品和生物制品的储存，加工和延长的保存期限。 根据本方法处理的特定生物材料是人血液和血液制品（RBC）。 还公开了用于保存食品，药物和生物产品以用于长期储存和延长保存期限的方法，其使用将材料的水合水平降低至小于特定产品的天然水合水平的方法。 本发明进一步提供了稳定的生物产品，例如以玻璃化珠粒的形式，使用根据所述方法的两相系统制备，所述两相系统可以被再水化并制备用于临床应用，并且基本上不丧失生物和/或药理学 活动。
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公开(公告)号：US20090303064A1
公开(公告)日：2009-12-10
申请号：US12477346
申请日：2009-06-03
IPC分类号： G08B21/00
CPC分类号： G01N29/07 , G01N29/30 , G01N29/4427 , G01N2291/02854 , G01N2291/2694
摘要： Alerting a user of a material inspection device to a change in thickness of a material being inspected is disclosed. A thickness offset is determined from calibration information. The calibration information identifies a time of flight of a pulse through a reference sample similar in composition to a material to be inspected. The thickness offset indicates when a thickness of a material being inspected differs from a thickness of the reference sample. A calibration thickness alarm is set, the calibration thickness alarm corresponding to the thickness offset. A change in thickness of the material being inspected is detected. The calibration thickness alarm is engaged to alert the user of the inspection device of a detected change in thickness of the material being inspected.
摘要翻译： 公开了材料检查装置的用户对所检查材料的厚度变化的警示。 从校准信息确定厚度偏移。 校准信息标识通过参考样品的脉冲的飞行时间，其类似于待检查的材料。 厚度偏移表示被检查材料的厚度何时与参考样品的厚度不同。 设置校准厚度报警，校准厚度报警对应于厚度偏移。 检测被检查材料的厚度变化。 校准厚度警报器被接合以向检查装置的用户通知检测到的被检查材料的厚度的变化。
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公开(公告)号：US20050186183A1
公开(公告)日：2005-08-25
申请号：US11007104
申请日：2004-12-08
申请人： Joseph DeAngelo , David Needham , Carroll Jones
发明人： Joseph DeAngelo , David Needham , Carroll Jones
CPC分类号： A61J1/10 , A01N1/02 , A01N1/0263 , A61M1/0209 , A61M1/0227 , A61M1/0272 , Y10S514/832 , Y10S514/833 , Y10S514/938 , Y10S514/939 , Y10S516/923 , Y10T428/2982
摘要： Disclosed is a multi-compartment medical device useful in the storage, processing and extended shelf life of perishable products, especially pharmaceutical, food and biological products. Particular biological materials processed according to the present methods are human blood and blood products (RBCs). Also disclosed are processes for preserving food, pharmaceutical and biological products for long-term storage and extended shelf life employing a process that reduces the hydration level of the material to less than native hydration levels of the specific product. The invention further provides stabilized biological products, such as in the form of glassified beads, prepared using a two-phase system according to the described processes that may be rehydrated and prepared for clinical use, and having essentially no loss of biological and/or pharmacological activity.
摘要翻译： 公开了一种多室医疗装置，其用于易腐食品，特别是制药，食品和生物制品的储存，加工和延长的保存期限。 根据本方法处理的特定生物材料是人血液和血液制品（RBC）。 还公开了用于保存食品，药物和生物产品以用于长期储存和延长保存期限的方法，其使用将材料的水合水平降低至小于特定产品的天然水合水平的方法。 本发明进一步提供了稳定的生物产品，例如以玻璃化珠粒的形式，使用根据所述方法的两相系统制备，所述两相系统可以被再水化并制备用于临床应用，并且基本上不丧失生物和/或药理学 活动。
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9.发明授权
公开(公告)号：US5554638A
公开(公告)日：1996-09-10
申请号：US246882
申请日：1994-05-20
IPC分类号： A61N5/02 , A61F7/00 , A61K31/00 , A61K31/195 , A61K31/198 , A61K31/4045 , A61K31/42 , A61K38/16 , A61K38/42 , A61K41/00 , A61K45/06 , A61P35/00 , A61P43/00 , A61K31/22 , A61K31/415
CPC分类号： A61K41/0052 , A61K31/00 , A61K31/195 , A61K31/198 , A61K31/4045 , A61K38/42 , Y10S514/832 , Y10S514/833 , Y10S514/929 , Y10S514/93
摘要： The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as an antitumor therapy to reduce tumor blood flow and oxygenation. The invention is also directed to administration of a nitric oxide scavenger or a nitric oxide synthase inhibitor to enhance the effectiveness of tumor therapy with hypoxic or acidic chemotherapeutic agents or hyperthermia. The invention is also directed to the administration of a nitric oxide synthase substrate to a subject previously administered a nitric oxide synthase inhibitor, in order to selectively inhibit tumor perfusion. In a specific example, administration of cell free hemoglobin, a nitric oxide scavenger, in conjunction with mitomycin C, a hypoxic cytotoxin, results in a significant delay in tumor growth of a human tumor xenograft in a mouse compared to mitomycin C alone. In another example, the administration of an inhibitor of nitric oxide synthase followed by the administration of a substrate of the enzyme causes a specific irreversible reduction of tumor blood flow, while normal blood flow is restored.
摘要翻译： 本发明涉及NO活性抑制剂如一氧化氮清除剂或NO合成酶抑制剂作为抗肿瘤疗法以减少肿瘤血流和氧合的用途。 本发明还涉及一氧化氮清除剂或一氧化氮合酶抑制剂的施用，以增强用缺氧或酸性化学治疗剂或热疗的肿瘤治疗的有效性。 本发明还涉及向先前施用一氧化氮合酶抑制剂的受试者施用一氧化氮合酶底物，以选择性地抑制肿瘤灌注。 在具体实例中，与丝裂霉素C单独相比，将无细胞血红蛋白（一氧化氮清除剂）与丝裂霉素C（缺氧细胞毒素）联合导致小鼠中人肿瘤异种移植物的肿瘤生长显着延迟。 在另一个实例中，一氧化氮合酶抑制剂的施用随后施用酶底物导致肿瘤血流的特异性不可逆降低，同时正常血流恢复。
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公开(公告)号：US08913006B2
公开(公告)日：2014-12-16
申请号：US13363550
申请日：2012-02-01
CPC分类号： G06F3/0227 , G06F9/445 , G06F9/451
摘要： A non-destructive inspection and testing instrument includes a housing and a first panel with a first type input to be assembled onto the housing and a second panel with a different, second type input to be assembled onto the housing. A first GUI module for the first panel implements a function upon an actuation of the first type input. A second GUI module for the second panel implements the same function upon an actuation of the second type input. A controller is configured to select the first GUI module when the first panel is associated with the instrument and to select the second GUI module when the second panel is associated with the instrument.
摘要翻译： 无损检测和测试仪器包括壳体和具有要组装到壳体上的第一类型输入的第一面板和具有不同的第二类型输入的第二面板，以组装到壳体上。 用于第一面板的第一GUI模块在第一类型输入的致动时实现功能。 用于第二面板的第二GUI模块在第二类型输入的致动时实现相同的功能。 控制器被配置为当第一面板与仪器相关联时选择第一GUI模块，并且当第二面板与仪器相关联时选择第二GUI模块。
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