公开(公告)号：US07546804B1

公开(公告)日：2009-06-16

申请号：US11548103

申请日：2006-10-10

申请人： Anthony E. Tartarilla, III ,  Henry Kerwien ,  Thomas DeVoe ,  Joseph Leone ,  Luke Helsel ,  Nicholas Turner

发明人： Anthony E. Tartarilla, III ,  Henry Kerwien ,  Thomas DeVoe ,  Joseph Leone ,  Luke Helsel ,  Nicholas Turner

IPC分类号： F42C19/00 ,  C06C7/00 ,  F42B5/26

CPC分类号： F42B5/38 ,  F42B3/113 ,  F42C19/085

摘要： An artillery charge includes a generally cylindrical body with a hollow core; propellant disposed in the body and first energetic material disposed in the hollow core; and a seal disposed over one end of the hollow core, the seal including second energetic material disposed therein. A laser igniter ignites the second energetic material in the seal, thereby providing more reliable ignition of the first energetic material and the propellant. The artillery charge reliably ignites using a lower powered laser than known charges.

摘要翻译： 火炮装药包括具有中空芯的大致圆筒体; 布置在体内的推进剂和设置在中空芯中的第一能量材料; 以及设置在所述中空芯的一端上的密封件，所述密封件包括设置在其中的第二能量材料。 激光点火器点燃密封件中的第二能量材料，从而为第一能量材料和推进剂提供更可靠的点燃。 使用比已知费用更低功率的激光可靠地点燃火炮充电。

公开(公告)号：US20180030754A1

公开(公告)日：2018-02-01

申请号：US15660460

申请日：2017-07-26

申请人： Joseph Leone

发明人： Joseph Leone

IPC分类号： E04H17/14 ,  E04H17/16

CPC分类号： E04H17/1443 ,  E04H17/1439 ,  E04H17/168 ,  E04H2017/1478 ,  E04H2017/1491

摘要： This invention relates to a fencing system and method for assembling a fence panel. The fencing system comprises pickets, braces and rails which can be assembled into a fence panel. The fence panel can be assembled by inserting the pickets through the slots of the brace and the opening of the rails when the brace is in the unlocked position. The assembled fence panel can be locked into place by longitudinally driving the braces relative to their respective rails from the unlocked position to the locked position.

公开(公告)号：US20080280842A1

公开(公告)日：2008-11-13

申请号：US11664564

申请日：2005-10-17

申请人： Malcolm MacCoss ,  David B. Olsen ,  Joseph Leone ,  Philippe L. Durette

发明人： Malcolm MacCoss ,  David B. Olsen ,  Joseph Leone ,  Philippe L. Durette

IPC分类号： A61K31/7064 ,  C07H19/04 ,  A61P31/12

CPC分类号： C07H19/14

摘要： The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such fluorinated pyrrolo[2,3-d]pyrimidine nucleoside alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the fluorinated pyrrolo[2,3-d]pyrimidine nucleoside of the present invention.

摘要翻译： 本发明提供了作为RNA依赖性RNA病毒聚合酶抑制剂的氟化吡咯并[2,3，d]嘧啶核苷化合物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。 本发明还描述了含有这种氟化吡咯并[2,3-d]嘧啶核苷的药物组合物，或者与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合。 还公开了本发明的氟化吡咯并[2,3-d]嘧啶核苷抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

公开(公告)号：US07756185B1

公开(公告)日：2010-07-13

申请号：US11998979

申请日：2007-10-31

申请人： Josiah W. Fay ,  Joseph Leone

发明人： Josiah W. Fay ,  Joseph Leone

IPC分类号： H01S3/09

CPC分类号： H01S3/093 ,  H01S3/025 ,  H01S3/061

摘要： A hardened pump laser comprises a hardened pump chamber that combines the functions of a conventional flash lamp and a conventional laser cavity flow tube. The hardened pump chamber comprises a hardened filter tube and electrodes. The electrodes are sealed to the hardened filter tube. A chamber in the hardened filter tube is filled with gas through the electrodes, then sealed. The hardened pump chamber performs the laser pumping function while further performing filtering and diffusion functions.

摘要翻译： 硬化泵激光器包括硬化泵室，其结合了常规闪光灯和常规激光腔流动管的功能。 硬化的泵室包括硬化的过滤管和电极。 电极被密封到硬化的过滤管上。 硬化过滤管中的一个腔室中充满了通过电极的气体，然后密封。 硬化泵室执行激光泵浦功能，同时进一步执行滤波和扩散功能。

公开(公告)号：US20210056652A1

公开(公告)日：2021-02-25

申请号：US16548847

申请日：2019-08-23

申请人： Joseph Adorno ,  Joseph Leone

发明人： Joseph Adorno ,  Joseph Leone

IPC分类号： G06Q50/22 ,  G16H10/60 ,  G06Q10/06 ,  G08B7/06

摘要： A child services platform is provided which may be utilized by one or more caregivers in electronic data communication with one or more child welfare entities. The one or more caregivers may determine a set of at least one first parameters associated with one or more minor children and may record the set of at least one first parameters into an electronic database. Responsive to determining the set of at least one first parameters, the one or more child welfare entities may determine a set of at least one second parameters associated with the one or more caregivers and may record the set of at least one second parameters into the electronic database. The set of at least one first parameters and the set of at least one second parameters may characterize a relationship between the one or more minor children and the one or more caregivers.

公开(公告)号：US08218597B1

公开(公告)日：2012-07-10

申请号：US12115195

申请日：2008-05-05

申请人： Josiah W. Fay ,  Joseph Leone ,  Henry Kerwien ,  Thomas DeVoe ,  Gregory Burke ,  Arthur A. Karpinski

发明人： Josiah W. Fay ,  Joseph Leone ,  Henry Kerwien ,  Thomas DeVoe ,  Gregory Burke ,  Arthur A. Karpinski

IPC分类号： H01S3/09

CPC分类号： H01S3/025 ,  F41A19/58 ,  H01S3/061 ,  H01S3/09408 ,  H01S3/0941 ,  H01S3/1611 ,  H01S3/1643

摘要： A diode pumped solid-state laser for high shock, high vibration environments such as those found in laser ignition systems for artillery systems.

摘要翻译： 用于高冲击，高振动环境的二极管泵浦固态激光器，例如用于炮兵系统的激光点火系统中的那些。