公开(公告)号：US20130200005A1

公开(公告)日：2013-08-08

申请号：US13879354

申请日：2011-10-14

申请人： Scott A. Mangiacotti ,  Parrish M. Galliher ,  Joseph J. Arduino ,  Michael Fisher ,  John J. Vicalvi, JR. ,  Joseph Makowiecki

发明人： Scott A. Mangiacotti ,  Parrish M. Galliher ,  Joseph J. Arduino ,  Michael Fisher ,  John J. Vicalvi, JR. ,  Joseph Makowiecki

IPC分类号： B01D61/22

CPC分类号： B01D61/22 ,  B01D61/145 ,  B01D2311/08 ,  B01D2311/25 ,  B01D2313/18 ,  B01D2313/20 ,  B01D2313/243 ,  B01D2313/58 ,  B01D2315/16 ,  B01D2317/08 ,  B01D2319/06 ,  C02F1/444 ,  C02F2209/005 ,  C02F2209/02 ,  C02F2209/03 ,  C02F2209/05 ,  C02F2209/11 ,  C02F2209/40 ,  B01D2311/04

摘要： A disposable filtration system can include a disposable filter housing having an ultrafiltration filter contained therein. The disposable filtration system can further include a feed inlet and retentate outlet in fluid communication on one side of the filter and a permeate conduit on the other side of the filter for withdrawing permeate that passes through the filter. The system can include at least one disposable pressure control valve in fluid communication with either the retentate outlet or the permeate conduit and configured to regulate the pressure within the housing.

摘要翻译： 一次性过滤系统可以包括其中包含超滤过滤器的一次性过滤器壳体。 一次性过滤系统还可以包括在过滤器的一侧处流体连通的进料入口和滞留物出口，以及在过滤器的另一侧的渗透管道，用于抽出通过过滤器的渗透物。 该系统可以包括至少一个一次性压力控制阀，其与渗余物出口或渗透物导管流体连通，并被配置成调节壳体内的压力。

公开(公告)号：US20130186834A1

公开(公告)日：2013-07-25

申请号：US13825829

申请日：2011-09-23

申请人： John J. Vicalvi ,  Joseph Makowiecki ,  Joseph D. Crowell ,  Parrish M. Galliher

发明人： John J. Vicalvi ,  Joseph Makowiecki ,  Joseph D. Crowell ,  Parrish M. Galliher

IPC分类号： B01D15/22

CPC分类号： B01D15/22 ,  B01F7/00141 ,  B01F7/00858 ,  B01F7/161 ,  B01F7/162 ,  B01F7/1695 ,  B01F7/22 ,  B01F13/0211 ,  B01F13/065 ,  B01F13/0827 ,  B01F15/00162 ,  B01F15/00175 ,  B01F15/0022 ,  B01F15/00227 ,  B01F15/0085 ,  B01F15/065 ,  G01N30/50 ,  G01N30/56 ,  G01N30/6017 ,  G01N30/603 ,  G01N2030/565

摘要： Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium, such as a chromatography resin. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion during use while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration. Alternatively, the agitator in the lowered position permits the chromatography resin packing material to operate in a mixed, slurry configuration.

摘要翻译： 公开了用于层析的方法和系统，其采用配置成装配在支撑结构内并适于接收过滤或吸收介质如色谱树脂的柔性容器。 柔性容器可以包括至少一个入口，至少一个出口和周边地密封在容器内的分离屏障，以将容器分离成树脂容纳部分和排出部分。 挡板可以构造成在使用期间将树脂材料从排水部分排除，同时允许流体通过。 一次性色谱系统还可以包括设置在柔性容器内的一个或多个搅拌器，并可调节地构造成在柔性容器中升高或降低。 当搅拌器处于升起位置时，树脂包装材料可以以沉降的填充床构型运行。 或者，处于降低位置的搅拌器允许色谱树脂包装材料以混合的浆料配置运行。

公开(公告)号：US10463988B2

公开(公告)日：2019-11-05

申请号：US13825829

申请日：2011-09-23

申请人： John J. Vicalvi ,  Joseph Makowiecki ,  Joseph D. Crowell ,  Parrish M. Galliher

发明人： John J. Vicalvi ,  Joseph Makowiecki ,  Joseph D. Crowell ,  Parrish M. Galliher

IPC分类号： B01D15/22 ,  G01N30/56 ,  B01F7/00 ,  B01F7/16 ,  B01F13/02 ,  B01F15/00 ,  B01F7/22 ,  B01F13/06 ,  B01F13/08 ,  G01N30/50 ,  G01N30/60 ,  B01F15/06

摘要： Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium, such as a chromatography resin. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion during use while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration. Alternatively, the agitator in the lowered position permits the chromatography resin packing material to operate in a mixed, slurry configuration.

公开(公告)号：US10010831B2

公开(公告)日：2018-07-03

申请号：US13879354

申请日：2011-10-14

申请人： Scott A. Mangiacotti ,  Parrish M. Galliher ,  Joseph J. Arduino ,  Michael Fisher ,  John J. Vicalvi, Jr. ,  Joseph Makowiecki

发明人： Scott A. Mangiacotti ,  Parrish M. Galliher ,  Joseph J. Arduino ,  Michael Fisher ,  John J. Vicalvi, Jr. ,  Joseph Makowiecki

IPC分类号： B01D35/00 ,  B01D61/22 ,  B01D61/14 ,  C02F1/44

CPC分类号： B01D61/22 ,  B01D61/145 ,  B01D2311/08 ,  B01D2311/25 ,  B01D2313/18 ,  B01D2313/20 ,  B01D2313/243 ,  B01D2313/58 ,  B01D2315/16 ,  B01D2317/08 ,  B01D2319/06 ,  C02F1/444 ,  C02F2209/005 ,  C02F2209/02 ,  C02F2209/03 ,  C02F2209/05 ,  C02F2209/11 ,  C02F2209/40 ,  B01D2311/04

摘要： A disposable filtration system can include a disposable filter housing having an ultrafiltration filter contained therein. The disposable filtration system can further include a feed inlet and retentate outlet in fluid communication on one side of the filter and a permeate conduit on the other side of the filter for withdrawing permeate that passes through the filter. The system can include at least one disposable pressure control valve in fluid communication with either the retentate outlet or the permeate conduit and configured to regulate the pressure within the housing.