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公开(公告)号：US20100104509A1
公开(公告)日：2010-04-29
申请号：US12519149
申请日：2007-12-13
IPC分类号： A61K51/00 , C07K16/00 , A61K39/395
CPC分类号： C07K16/2803 , A61K47/6803 , A61K47/6849 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Human monoclonal antibodies that specifically bind to CD19 with high affinity are disclosed The antibodies are capable of internalizing into CD19-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies are also provided Also provided are methods for detecting CD19, as well as methods for treating cancers, such as B cell malignancies, for example, non-Hodgkin's lymphoma, chronic lymphocytic leukemias, follicular lymphomas, diffuse large cell lymphomas of B lineage, and multiple myelomas using an anti-CD 19 anti-body
摘要翻译： 公开了以高亲和力特异性结合CD19的人单克隆抗体。抗体能够内化成表达CD19的细胞或能够介导抗原依赖性细胞毒性编码抗体，表达载体，宿主细胞的核酸分子和表达 还提供了抗体还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含抗体的药物组合物。还提供了用于检测CD19的方法，以及用于治疗癌症的方法，例如B细胞恶性肿瘤，例如非霍奇金淋巴瘤 ，慢性淋巴细胞性白血病，滤泡性淋巴瘤，B系弥漫性大细胞淋巴瘤，以及使用抗CD19抗体的多种骨髓瘤
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公开(公告)号：US20090142349A1
公开(公告)日：2009-06-04
申请号：US11917750
申请日：2006-06-20
申请人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
发明人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
IPC分类号： A61K39/395 , C07K16/18 , C12N15/13 , C12N15/85 , C12N5/10 , C12P21/08 , A61P35/00 , A61P19/02
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/732 , C07K2317/77 , Y02A50/412
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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公开(公告)号：US08097703B2
公开(公告)日：2012-01-17
申请号：US11917750
申请日：2006-06-20
申请人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
发明人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/732 , C07K2317/77 , Y02A50/412
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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公开(公告)号：US20100150950A1
公开(公告)日：2010-06-17
申请号：US12518838
申请日：2007-12-13
申请人： Marco A. Coccia , Jonathan A. Terrett , David John King , Chin Pan , Josephine Cardarelli , Mark Yamanaka , Ann Karla Henning
发明人： Marco A. Coccia , Jonathan A. Terrett , David John King , Chin Pan , Josephine Cardarelli , Mark Yamanaka , Ann Karla Henning
IPC分类号： A61K39/395 , C07K16/00 , A61K38/16 , A61P35/00 , A61P29/00 , A61P31/12 , A61P37/00 , C12N5/09
CPC分类号： C07K16/2875 , A61K47/65 , A61K47/6809 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CD70 with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human CD70. In certain embodiments, the antibodies are capable of being internalized into CD70-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD70, as well as methods for treating cancers, such as renal cancer and lymphomas, using an anti-CD7Q antibody of this disclosure.
摘要翻译： 本公开提供了以高亲和力特别是人单克隆抗体特异性结合CD70的分离的单克隆抗体。 优选地，抗体结合人CD70。 在某些实施方案中，抗体能够内化于表达CD70的细胞中，或能够介导抗原依赖性细胞毒性。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了使用本公开的抗CD7Q抗体检测CD70的方法以及用于治疗癌症（例如肾癌和淋巴瘤）的方法。
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公开(公告)号：US08481683B2
公开(公告)日：2013-07-09
申请号：US12517183
申请日：2007-11-30
申请人： David John King , Alison Witte , Heidi N. LeBlanc , Richard Theolis , Asna Masood , Mark Yamanaka , Kyra D. Zens , Sarah R. Reed , Tim Sproul , Chetana Rao-Naik , David Passmore , Dawn M. Tanamachi , Kristopher Toy
发明人： David John King , Alison Witte , Heidi N. LeBlanc , Richard Theolis , Asna Masood , Mark Yamanaka , Kyra D. Zens , Sarah R. Reed , Tim Sproul , Chetana Rao-Naik , David Passmore , Dawn M. Tanamachi , Kristopher Toy
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , A61K39/40 , C07K1/00
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K47/6829 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/3061 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure.
摘要翻译： 本公开提供了以高亲和力特别是人单克隆抗体特异性结合CD22的分离的单克隆抗体。 还提供编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测CD22的方法，以及使用本公开的抗CD22抗体治疗各种癌症和炎性和自身免疫性疾病的方法。
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公开(公告)号：US20100143368A1
公开(公告)日：2010-06-10
申请号：US12517183
申请日：2007-11-30
申请人： David John King , Alison Witte , Heidi N. LeBlanc , Richard Theolis , Asna Masood , Mark Yamanaka , Kyra D. Emory , Sarah R. Reed , Tim Sproul , Chetana Rao-Naik , David Passmore
发明人： David John King , Alison Witte , Heidi N. LeBlanc , Richard Theolis , Asna Masood , Mark Yamanaka , Kyra D. Emory , Sarah R. Reed , Tim Sproul , Chetana Rao-Naik , David Passmore
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K47/6829 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/3061 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure.
摘要翻译： 本公开提供了以高亲和力特别是人单克隆抗体特异性结合CD22的分离的单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测CD22的方法，以及使用本公开的抗CD22抗体治疗各种癌症和炎性和自身免疫性疾病的方法。
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公开(公告)号：US08124738B2
公开(公告)日：2012-02-28
申请号：US12065436
申请日：2006-09-26
申请人： Jonathan Alexander Terret , Li-sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
发明人： Jonathan Alexander Terret , Li-sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
IPC分类号： C07K16/00 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
摘要翻译： 本公开提供以高亲和力特异性结合CD70的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症，自身免疫疾病，炎症和病毒感染的方法。
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公开(公告)号：US20090028872A1
公开(公告)日：2009-01-29
申请号：US12065436
申请日：2006-09-26
申请人： Jonathan Alexander Terret , Li-Sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
发明人： Jonathan Alexander Terret , Li-Sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
摘要翻译： 本公开提供以高亲和力特异性结合CD70的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症，自身免疫疾病，炎症和病毒感染的方法。
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公开(公告)号：US20080279868A1
公开(公告)日：2008-11-13
申请号：US12088066
申请日：2006-09-26
申请人： Sharon Elaine Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Bilal Sufi , Haichun Huang , David John King , Chin Pan , Josephine M. Cardarelli
发明人： Sharon Elaine Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Bilal Sufi , Haichun Huang , David John King , Chin Pan , Josephine M. Cardarelli
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
摘要： The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.
摘要翻译： 本公开提供了抗体 - 药物偶联物，其是有效的细胞毒素，其中药物通过接头与抗体连接。 本公开还涉及含有抗体 - 药物共轭物的组合物，以及使用它们的治疗方法。
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公开(公告)号：US07402662B2
公开(公告)日：2008-07-22
申请号：US11374231
申请日：2006-03-13
申请人： Dilijeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
发明人： Dilijeet Singh Athwal , Derek Thomas Brown , Andrew Neil Charles Weir , Andrew George Popplewell , Andrew Paul Chapman , David John King
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04 , C07H21/04
CPC分类号： C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.
摘要翻译： 公开了含有至少一种衍生自对人TNFα具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体，其中至少一个CDR是杂交CDR。 进一步公开的是编码抗体分子链，载体，转化宿主细胞的链DNA序列和抗体分子在治疗由TNFα介导的疾病中的用途。
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