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公开(公告)号：US20120270792A1
公开(公告)日：2012-10-25
申请号：US13328821
申请日：2011-12-16
申请人： Wylie W. Vale, JR. , Kathy A. Lewis , Marilyn H. Perrin , Koichi S. Kunitake , Jean E. Rivier , Jozsef Gulyas
发明人： Wylie W. Vale, JR. , Kathy A. Lewis , Marilyn H. Perrin , Koichi S. Kunitake , Jean E. Rivier , Jozsef Gulyas
CPC分类号： A61K38/2228 , A61K38/00 , C07K14/57509 , C07K14/695
摘要： A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
摘要翻译： 公众人类基因组数据库的搜索确定了人类EST，GenBank登录号AW293249，其与已知的河豚urocortin序列具有高同源性。 从人类基因组DNA扩增全长序列并进行测序。 新序列与人尿皮质素I和尿皮质素II的序列同源性比较显示，该序列编码了一种新的人类urocortin，其命名为urocortin III（UcnIII）。 虽然urocortin III对CRF-R1或CRF-R2没有高亲和力，但CRF-R2的亲和力大于对CRF-R1的亲和力。 Urocortin III能够刺激表达CRF-R2α或bgr的细胞中的环AMP产生。 因此，亲和力足够高，使得尿皮质素III可以作为CRF-R2的天然激动剂。 然而，urocortin III也可能是未被鉴定的受体的更强的激动剂。
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公开(公告)号：US07851588B2
公开(公告)日：2010-12-14
申请号：US12366816
申请日：2009-02-06
IPC分类号： A61K38/12
CPC分类号： C07K14/47 , A61K38/00 , C07K14/57509
摘要： CRF peptide analogs that bind to CRFR1 with an affinity far greater than they bind to CRFR2. Some of these analogs exhibit CRF agonist activity. One exemplary analog that may be made by solid-phase synthesis is:(cyclo 31-34)[Ac-Pro4,D-Phe12,Nle18,21,Glu31,Lys34]-sucker urotensin(4-41).
摘要翻译： 结合CRFR1的CRF肽类似物的亲和力远远大于它们与CRFR2结合的亲和力。 这些类似物中的一些表现出CRF激动剂活性。 可以通过固相合成制备的一个示例性类似物是：（环31-34）[Ac-Pro4，D-Phe12，Nle18,21，Glu31，Lys34]刺激性尿素转运蛋白（4-41）。
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公开(公告)号：US07498300B2
公开(公告)日：2009-03-03
申请号：US10763935
申请日：2004-01-22
IPC分类号： A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/57509
摘要： CRF peptide analogs that bind to CRFR1 with an affinity far greater than they bind to CRFR2. These analogs exhibit CRF agonist activity. One exemplary analog that may be made by solid-phase synthesis is (cyclo 31-34)[Ac-Pro4, D-Phe12, Nle21,38, Glu31, Lys34]-r/hCRF(4-41).
摘要翻译： 结合CRFR1的CRF肽类似物的亲和力远远大于它们与CRFR2结合的亲和力。 这些类似物表现出CRF激动剂活性。 可以通过固相合成制备的一个示例性类似物是（环31-34）[Ac-Pro4，D-Phe12，Nle21,38，Glu31，Lys34] -r / hCRF（4-41）。
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公开(公告)号：US20060003937A1
公开(公告)日：2006-01-05
申请号：US11214371
申请日：2005-08-29
申请人： Wylie Vale , Kathy Lewis , Marilyn Perrin , Koichi Kunitake , Jean Rivier , Jozsef Gulyas
发明人： Wylie Vale , Kathy Lewis , Marilyn Perrin , Koichi Kunitake , Jean Rivier , Jozsef Gulyas
CPC分类号： A61K38/2228 , A61K38/00 , C07K14/57509 , C07K14/695
摘要： A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
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5.发明授权Process and apparatus for producing a urea fatty acid adduct consisting of solid particles 失效用于生产由固体颗粒组成的尿素脂肪酸加合物的方法和设备
公开(公告)号：US4145446A
公开(公告)日：1979-03-20
申请号：US792561
申请日：1977-05-02
申请人： Eva Kurucz , Piroska Lukacs , Lajos Kollar , Jozsef Barics , Jozsef Gulyas , Laszlo Zolna , Balazs Juhasz , Lajos Fodor , Sandor Gal , Janos Hollo , Erno Pungor , Janisz Sztatisz , Jeno Zolnay
发明人： Eva Kurucz , Piroska Lukacs , Lajos Kollar , Jozsef Barics , Jozsef Gulyas , Laszlo Zolna , Balazs Juhasz , Lajos Fodor , Sandor Gal , Janos Hollo , Erno Pungor , Janisz Sztatisz , Jeno Zolnay
CPC分类号： B01J2/04 , A23K20/105 , A23K20/158 , A23K50/15 , Y10S426/807
摘要： A process is disclosed for the production of a urea-fatty acid adduct composed of discrete solid particles and having high protein and starch equivalent values wherein an aqueous solution or melt of urea at increased temperature is reacted with a fatty acid or a mixture of fatty acid and neutral fat at an increased temperature in a weight ratio of urea to fatty acid between 40 : 60 and 60 : 40 in a confined reacting space for about 2.5 to 10 seconds and wherein the mixture has been sprayed into a spraying space to allow the particles to crystallize in the air stream from the spraying.
摘要翻译： 公开了一种用于生产由离散固体颗粒组成的具有高蛋白质和淀粉当量值的尿素 - 脂肪酸加合物的方法，其中将水溶液或升高温度的尿素熔体与脂肪酸或脂肪酸的混合物反应 和在限制反应空间中在40-60和60:40之间的尿素与脂肪酸的重量比在升高的温度下的中性脂肪约2.5至10秒，并且其中混合物已被喷雾到喷雾空间中以允许颗粒 在喷雾的气流中结晶。
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公开(公告)号：US20090149629A1
公开(公告)日：2009-06-11
申请号：US12366816
申请日：2009-02-06
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , C07K14/57509
摘要： CRF peptide analogs that bind to CRFR1 with an affinity far greater than they bind to CRFR2. Some of these analogs exhibit CRF agonist activity. One exemplary analog that may be made by solid-phase synthesis is:(cyclo 31-34)[Ac-Pro4, D-Phe12, Nle18,21, Glu31, Lys34]-sucker urotensin(4-41).
摘要翻译： 结合CRFR1的CRF肽类似物的亲和力远远大于它们与CRFR2结合的亲和力。 这些类似物中的一些表现出CRF激动剂活性。 可以通过固相合成制备的一个示例性类似物是：（环31-34）[Ac-Pro4，D-Phe12，Nle18,21，Glu31，Lys34]刺激性尿素转运蛋白（4-41）。
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公开(公告)号：US08084413B2
公开(公告)日：2011-12-27
申请号：US12266430
申请日：2008-11-06
申请人： Wylie W. Vale, Jr. , Kathy A. Lewis , Marilyn H. Perrin , Koichi S. Kunitake , Jean E. Rivier , Jozsef Gulyas
发明人： Wylie W. Vale, Jr. , Kathy A. Lewis , Marilyn H. Perrin , Koichi S. Kunitake , Jean E. Rivier , Jozsef Gulyas
IPC分类号： C07K14/00
CPC分类号： A61K38/2228 , A61K38/00 , C07K14/57509 , C07K14/695
摘要： A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
摘要翻译： 公众人类基因组数据库的搜索确定了人类EST，GenBank登录号AW293249，其与已知的河豚urocortin序列具有高同源性。 从人类基因组DNA扩增全长序列并进行测序。 新序列与人尿皮质素I和尿皮质素II的序列同源性比较显示，该序列编码了一种新的人类urocortin，其命名为urocortin III（UcnIII）。 虽然urocortin III对CRF-R1或CRF-R2没有高亲和力，但CRF-R2的亲和力大于对CRF-R1的亲和力。 Urocortin III能够刺激表达CRF-R2α或bgr的细胞中的环AMP产生。 因此，亲和力足够高，使得尿皮质素III可以作为CRF-R2的天然激动剂。 然而，urocortin III也可能是未被鉴定的受体的更强的激动剂。
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公开(公告)号：US07141546B1
公开(公告)日：2006-11-28
申请号：US10210889
申请日：2002-07-31
CPC分类号： C07K14/4703 , A61K38/00 , G01N33/74 , G01N2500/02
摘要： CRF peptide analogs that bind to CRFR2 with an affinity far greater than they bind to CRFR1. These analogs exhibit CRF antagonist activity, and they can be based upon the native structures of sauvagine, CRF, and urocortin.
摘要翻译： 结合CRFR2的CRF肽类似物的亲和力远远大于它们与CRFR1结合的亲和力。 这些类似物显示CRF拮抗剂活性，它们可以基于sauvagine，CRF和尿皮质素的天然结构。
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公开(公告)号：US4914189A
公开(公告)日：1990-04-03
申请号：US011152
申请日：1987-02-05
申请人： Andrew V. Schally , Jozsef Gulyas , Sandor Bajusz
发明人： Andrew V. Schally , Jozsef Gulyas , Sandor Bajusz
IPC分类号： A61K38/27 , A61K38/00 , A61K38/04 , C07K1/04 , C07K1/06 , C07K1/113 , C07K14/00 , C07K14/575 , C07K14/60
摘要： Human pancreatic GRF (hpGRF), rat hypothalamic GRF (rGRF) and porcine hypothalamic GRF (pGRF) have been earlier characterized and synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals, including humans, which have resistance to enzymatic degradation in the body, and which have the sequence: ##STR1## wherein Q.sup.1 is an omega or alpha-omega substituted alkyl,Q.sup.2 is a lower omega-quanidino-alkyl group.R.sub.2 is Ala, D-Ala, or D-N-Methyl-AlaR.sub.3 is Asp, D-Asp, Glu, or D-GluR.sub.8 is Asn, D-Asn, Ser, or D-SerR.sub.10 is Tyr or D-TyrR.sub.12 is Lys, D-Lys Arg or OrnR.sub.13 is Val or IleR.sub.14 is Leu or D-LeuR.sub.15 is Gly, N-Methyl-Gly, or D-AlaR.sub.17 is Leu or D-LeuR.sub.18 is Tyr or SerR.sub.23 is Leu or D-LeuR.sub.24 is Gln or HisR.sub.25 is Asp, D-Asp, Glu, or D-GluR.sub.27 is Met, D-Met, Ala, Nle, Ile, Val, Nva, LeuR.sub.28 is Asn or SerThe peptides as well as nontoxic salts thereof may be administered to animals, including humans and cold-blooded animals, to stimulate the release of GH and may be used diagnostically.
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公开(公告)号：US08445425B2
公开(公告)日：2013-05-21
申请号：US13328821
申请日：2011-12-16
申请人： Wylie W. Vale, Jr. , Kathy A. Lewis , Marilyn H. Perrin , Koichi S. Kunitake , Jean E. Rivier , Jozsef Gulyas
发明人： Wylie W. Vale, Jr. , Kathy A. Lewis , Marilyn H. Perrin , Koichi S. Kunitake , Jean E. Rivier , Jozsef Gulyas
IPC分类号： C07K14/00
CPC分类号： A61K38/2228 , A61K38/00 , C07K14/57509 , C07K14/695
摘要： A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
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