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1.发明授权公开(公告)号：US07691995B2
公开(公告)日：2010-04-06
申请号：US10195034
申请日：2002-07-12
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
摘要翻译： 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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2.发明授权公开(公告)号：US08232260B2
公开(公告)日：2012-07-31
申请号：US13031522
申请日：2011-02-21
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vitro with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
摘要翻译： 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适调控序列的这些工程化RNA前体编码的核酸分子引入体外，工程改造的RNA前体的表达可以在时间上和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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公开(公告)号：US20100234448A1
公开(公告)日：2010-09-16
申请号：US12727783
申请日：2010-03-19
IPC分类号： A61K31/7088 , C12N15/113 , C12N15/63 , C12N5/10
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
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4.发明申请公开(公告)号：US20080200420A1
公开(公告)日：2008-08-21
申请号：US12079531
申请日：2008-03-26
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
摘要翻译： 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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5.发明申请公开(公告)号：US20060009402A1
公开(公告)日：2006-01-12
申请号：US10195034
申请日：2002-07-12
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
摘要翻译： 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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6.发明授权公开(公告)号：US08557785B2
公开(公告)日：2013-10-15
申请号：US12729360
申请日：2010-03-23
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
摘要翻译： 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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7.发明申请公开(公告)号：US20110207224A1
公开(公告)日：2011-08-25
申请号：US13031522
申请日：2011-02-21
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vitro with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
摘要翻译： 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适调控序列的这些工程化RNA前体编码的核酸分子引入体外，工程改造的RNA前体的表达可以在时间上和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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8.发明申请公开(公告)号：US20100233810A1
公开(公告)日：2010-09-16
申请号：US12729360
申请日：2010-03-23
IPC分类号： C12N5/02
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
摘要翻译： 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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公开(公告)号：US08530438B2
公开(公告)日：2013-09-10
申请号：US12727783
申请日：2010-03-19
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
摘要翻译： 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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10.发明授权公开(公告)号：US07893036B2
公开(公告)日：2011-02-22
申请号：US12079531
申请日：2008-03-26
CPC分类号： C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
摘要： The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
摘要翻译： 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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