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7 条记录 (耗时 0.011 秒)

    Biologically useful polymer preparations
    2.
    发明授权
    Biologically useful polymer preparations 失效
    生物有用的聚合物制剂

    公开(公告)号：US4772484A

    公开(公告)日：1988-09-20

    申请号：US63583

    申请日：1987-06-17

    申请人： Judith P. Kitchell ,  Stanton R. de Riel

    发明人： Judith P. Kitchell ,  Stanton R. de Riel

    IPC分类号： A61K9/70 ,  A61L15/22 ,  A01N1/02

    CPC分类号： A61K9/7053 ,  A61K9/7007 ,  A61L15/225

    摘要： Described and claimed are biologically useful crosslinked copolymers of vinyl pyrrolidone and allylamine suitable for various preventative and therapeutic applications to intact or injured skin. Coatings of these copolymers, either preformed or prepared in situ on the skin may deliver medicaments to the skin, may serve as an iontophoretic medium, may provide electrical contact with the body, may regulate or control moisture loss from injured integument. Monolithic devices for the delivery of pharmaceutically active agents within living tissue may be formulated from these copolymers.

    摘要翻译： 描述和要求保护的是乙烯基吡咯烷酮和烯丙胺的生物有用的交联共聚物，其适用于完整或受伤皮肤的各种预防和治疗应用。 这些共聚物的涂层，在皮肤上预先形成或原位制备，可将药物递送至皮肤，可用作离子电渗介质，可提供与身体的电接触，可调节或控制损伤皮肤的水分流失。 可以从这些共聚物配制用于在活组织内递送药物活性剂的单片装置。

    Biologically useful polymer preparations
    3.
    发明授权
    Biologically useful polymer preparations 失效

    公开(公告)号：US4692328A

    公开(公告)日：1987-09-08

    申请号：US780162

    申请日：1985-09-24

    申请人： Judith P. Kitchell ,  Stanton R. de Riel

    发明人： Judith P. Kitchell ,  Stanton R. de Riel

    IPC分类号： A61K9/70 ,  A61L15/22 ,  A61K31/74

    CPC分类号： A61K9/7053 ,  A61K9/7007 ,  A61L15/225

    摘要： Described and claimed are biologically useful crosslinked copolymers of vinyl pyrrolidone and allylamine suitable for various preventative and therapeutic applications to intact or injured skin. Coatings of these copolymers, either preformed or prepared in situ on the skin may deliver medicaments to the skin, may serve as an iontophoretic medium, may provide electrical contact with the body, may regulate or control moisture loss from injured integument. Monolithic devices for the delivery of pharmaceutically active agents within living tissue may be formulated from these copolymers.

    Immunobooster for delayed release of immunogen
    4.
    发明授权
    Immunobooster for delayed release of immunogen 失效
    免疫球蛋白用于免疫原的延迟释放

    公开(公告)号：US5656298A

    公开(公告)日：1997-08-12

    申请号：US396363

    申请日：1995-02-28

    申请人： Judith P. Kitchell ,  Stephen C. Crooker

    发明人： Judith P. Kitchell ,  Stephen C. Crooker

    IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/26 ,  A61K39/39 ,  A61K9/14

    CPC分类号： A61K39/39 ,  A61K9/1611 ,  A61K9/1647 ,  A61K9/2009 ,  A61K9/204 ,  A61K2039/55505 ,  A61K2039/55555

    摘要： An immunobooster capable of delivering an immunogen to an individual or animal in a controlled release manner is described. The immunobooster contains an immunogen/hydrophobic polymer matrix with a swelling agent such that the swelling agent can swell in an aqueous environment and burst the matrix. The immunogen is released in a pulsed release manner after a desired time interval has elapsed subsequent to administration of the immunobooster. The immunobooster eliminates the need for multiple administrations of immunogen in order to build lasting immunity. Also described are methods of preparing and using the immunobooster, and kits containing the immunobooster.

    摘要翻译： 描述了能够以受控释放方式向个体或动物递送免疫原的免疫球体。 免疫球蛋白含有具有溶胀剂的免疫原/疏水性聚合物基质，使得溶胀剂可在水性环境中溶胀并使基质爆裂。 在给予免疫球蛋白后经过所需时间间隔后，以脉冲释放的方式释放免疫原。 免疫球蛋白消除了多次免疫原的施用，以建立持久的免疫力。 还描述了制备和使用免疫球蛋白的方法和含有免疫球蛋白的试剂盒。

    Controlled, sustained release delivery system for treating drug dependency
    6.
    发明授权
    Controlled, sustained release delivery system for treating drug dependency 失效
    用于治疗药物依赖性的受控的持续释放递送系统

    公开(公告)号：US5486362A

    公开(公告)日：1996-01-23

    申请号：US140280

    申请日：1993-10-21

    申请人： Judith P. Kitchell ,  Indu A. Muni ,  Yvonne N. Boyer

    发明人： Judith P. Kitchell ,  Indu A. Muni ,  Yvonne N. Boyer

    IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/70 ,  A61K31/445 ,  A61F2/02 ,  A61K9/48 ,  A61K9/50

    CPC分类号： A61K31/445 ,  A61K9/1647 ,  A61K9/7023 ,  A61K9/009 ,  Y10S514/81 ,  Y10S514/811 ,  Y10S514/812 ,  Y10S514/813 ,  Y10S514/953 ,  Y10S514/955 ,  Y10S514/963 ,  Y10S514/965

    摘要： A drug delivery system useful in treating an individual for a drug dependence is described. One embodiment of the system is useful for aiding individuals in the cessation of smoking or chewing nicotine containing products is described. The delivery system includes a physical constraint modulation system (PCMS.TM.) containing lobeline. The drug delivery system is capable of delivering lobeline to an individual in a controlled, sustained release manner and providing long-term therapeutic levels of lobeline to the individual. The delivery of lobeline in such a manner reduces or eliminates the individual's smoking or chewing habit. The PCMS may be a biodegradable polymer containing the lobeline capable of subcutaneous or intramuscular injection or implantation into the individual or may be part of a transdermal patch containing lobeline. Also described are methods of using the drug delivery systems in treating other drug dependencies and kits containing the drug delivery systems.

    摘要翻译： 描述了可用于治疗个体药物依赖性的药物递送系统。 该系统的一个实施方案可用于帮助个体停止吸烟或咀嚼含有尼古丁的产品。 递送系统包括包含小叶的物理约束调制系统（PCMS TM）。 药物递送系统能够以受控的，持续释放的方式向个体递送小叶，并向个体提供长期治疗水平的叶片。 以这种方式递送小叶减少或消除个体的吸烟或咀嚼习惯。 PCMS可以是包含能够皮下或肌内注射或植入个体的小叶的可生物降解的聚合物，或者可以是含有叶的透皮贴片的一部分。 还描述了使用药物递送系统来治疗其它药物依赖性的方法和含有药物递送系统的试剂盒。