公开(公告)号：US07253187B2

公开(公告)日：2007-08-07

申请号：US10770814

申请日：2004-02-03

申请人： Jingrong Cao ,  Jeremy Green ,  Michael Hale ,  Francois Maltais ,  Judy Straub ,  Qing Tang ,  Alex Aronov

发明人： Jingrong Cao ,  Jeremy Green ,  Michael Hale ,  Francois Maltais ,  Judy Straub ,  Qing Tang ,  Alex Aronov

IPC分类号： C07D401/04 ,  A61K31/4427

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

摘要翻译： 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中Z 1和Z 2各自独立地为氮或CH并且环A，T m 第二，第二，第二，第三，第三和第三，第二，如 规范。 该化合物特别可用作ERK2的抑制剂，并且用于治疗由蛋白激酶抑制剂，特别是癌症，炎性疾病，再狭窄，糖尿病和心血管疾病等疾病缓解的哺乳动物疾病。

公开(公告)号：US06743791B2

公开(公告)日：2004-06-01

申请号：US10071699

申请日：2002-02-08

申请人： Jingrong Cao ,  Jeremy Green ,  Michael Hale ,  Francois Maltais ,  Judy Straub ,  Qing Tang ,  Alex Aronov

发明人： Jingrong Cao ,  Jeremy Green ,  Michael Hale ,  Francois Maltais ,  Judy Straub ,  Qing Tang ,  Alex Aronov

IPC分类号： C07D40304

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

摘要翻译： 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中Z 1和Z 2各自独立地为氮或CH，环A，TmR 1，Q 2，R un R 3， 和Sp如说明书中所述。 该化合物特别可用作ERK2的抑制剂，并且用于治疗由蛋白激酶抑制剂，特别是癌症，炎性疾病，再狭窄，糖尿病和心血管疾病等疾病缓解的哺乳动物疾病。

公开(公告)号：US20070265263A1

公开(公告)日：2007-11-15

申请号：US11803878

申请日：2007-05-16

申请人： Jingrong Cao ,  Jeremy Green ,  Michael Hale ,  Francois Maltais ,  Judy Straub ,  Oing Tang ,  Alex Aronov

发明人： Jingrong Cao ,  Jeremy Green ,  Michael Hale ,  Francois Maltais ,  Judy Straub ,  Oing Tang ,  Alex Aronov

IPC分类号： C07D401/02 ,  A61K31/506 ,  A61K31/5375 ,  C07D413/14 ,  C07D403/02 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.