公开(公告)号：US20070265263A1

公开(公告)日：2007-11-15

申请号：US11803878

申请日：2007-05-16

申请人： Jingrong Cao ,  Jeremy Green ,  Michael Hale ,  Francois Maltais ,  Judy Straub ,  Oing Tang ,  Alex Aronov

发明人： Jingrong Cao ,  Jeremy Green ,  Michael Hale ,  Francois Maltais ,  Judy Straub ,  Oing Tang ,  Alex Aronov

IPC分类号： C07D401/02 ,  A61K31/506 ,  A61K31/5375 ,  C07D413/14 ,  C07D403/02 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

公开(公告)号：US20050215550A1

公开(公告)日：2005-09-29

申请号：US11030004

申请日：2005-01-05

申请人： Oing Tang ,  Francois Maltais ,  James Janetka ,  Michael Hale

发明人： Oing Tang ,  Francois Maltais ,  James Janetka ,  Michael Hale

IPC分类号： A61K31/4155 ,  A61K31/4439 ,  A61K31/5377 ,  A61K45/00 ,  A61P1/16 ,  A61P3/10 ,  A61P5/00 ,  A61P7/00 ,  A61P7/04 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P17/06 ,  A61P19/00 ,  A61P21/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P27/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P39/00 ,  A61P43/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  A61K31/416 ,  C07D413/14 ,  C07D43/14

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14

摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: where B, R1, n, R3, Q, and R4 are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

摘要翻译： 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中B，R 1，n，R 3，Q和R 4， SUP>在说明书中描述。 该化合物可用于治疗由蛋白激酶抑制剂，特别是癌症，炎症性疾病，再狭窄和心血管疾病等疾病减轻的哺乳动物的疾病状态。

公开(公告)号：US07279476B2

公开(公告)日：2007-10-09

申请号：US11030004

申请日：2005-01-05

申请人： Oing Tang ,  Francois Maltais ,  James Walter Janetka ,  Michael Robin Hale

发明人： Oing Tang ,  Francois Maltais ,  James Walter Janetka ,  Michael Robin Hale

IPC分类号： A61K31/5377 ,  A61K31/44 ,  A61K31/415 ,  C07D413/14 ,  C07D401/14

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14

摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: where B, R1, n, R3, Q, and R4 are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

摘要翻译： 本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中B，R 1，n，R 3，Q和R 4， SUP>在说明书中描述。 该化合物可用于治疗由蛋白激酶抑制剂，特别是癌症，炎症性疾病，再狭窄和心血管疾病等疾病减轻的哺乳动物的疾病状态。

公开(公告)号：US5835880A

公开(公告)日：1998-11-10

申请号：US503943

申请日：1995-07-19

申请人： Zhongxue Gan ,  Wei-Ping Wang ,  Oing Tang ,  Ruiming Zhang ,  John Moh

发明人： Zhongxue Gan ,  Wei-Ping Wang ,  Oing Tang ,  Ruiming Zhang ,  John Moh

IPC分类号： G01S5/16 ,  G05D1/02 ,  G06T7/00 ,  G06K9/00 ,  G08G1/017

CPC分类号： G06K9/00791 ,  G01S5/16 ,  G05D1/0251 ,  G06K9/3216 ,  G06K9/3241 ,  G06T7/0075 ,  G06K2209/23

摘要： In an apparatus and method for automatic vehicle following, a pair of video cameras are mounted on the front portion of a following vehicle, and each camera generates image data indicative of a respective image of a distinctive mark located on a rearward portion of a lead vehicle. An image processor generates two one-dimensional image-intensity distributions for each mark image based on the image data, and in turn generates a respective edge-intensity distribution based on each image-intensity distribution. The edge-intensity distributions are each generated by taking the first derivative of the respective image-intensity distribution. The image processor in turn generates a respective feature vector based on each edge-intensity distribution, wherein the vector components of each feature vector define select characteristics of the respective mark image. The center points of the two corresponding mark images are determined based on the feature vectors, and a signal processor generates signals indicative of the following distance and the heading angle of the lead vehicle based on the image center points. A window enclosing each mark image is moved upon generating a new mark image to the approximate center point of the preceding image, to substantially follow image movements from one camera image frame to the next, and thereby suppress noise and enhance the image-processing speed of the apparatus.

摘要翻译： 在用于自动车辆跟随的装置和方法中，一对摄像机安装在后续车辆的前部，并且每个摄像机产生指示位于引导车辆的后部上的特征标记的各自图像的图像数据 。 图像处理器基于图像数据为每个标记图像生成两个一维图像强度分布，并且依次生成基于每个图像强度分布的相应边缘强度分布。 边缘强度分布各自通过取出各个图像强度分布的一阶导数来产生。 图像处理器又基于每个边缘强度分布产生相应的特征向量，其中每个特征向量的向量分量定义相应标记图像的选择特征。 基于特征矢量确定两个对应的标记图像的中心点，并且信号处理器基于图像中心点产生指示跟随距离和前导车辆的前进角度的信号。 在产生新的标记图像到前一图像的近似中心点的同时移动包围每个标记图像的窗口，以基本上跟随从一个相机图像帧到下一个图像帧的图像移动，从而抑制噪声并提高图像处理速度 该装置。