公开(公告)号：US20080228589A1

公开(公告)日：2008-09-18

申请号：US12015143

申请日：2008-01-16

申请人： Ryan T. Koehler ,  Kenneth J. Livak ,  Junko Stevens ,  Francisco M. De La Vega ,  Michael Rhodes ,  Laurent R. Bellon ,  Julie Williams ,  Dennis A. Gilbert ,  Charles R. Scafe ,  Hadar I. Avi-Itzhak ,  Lily Xu ,  Susan Eddins ,  Michael W. Hunkapiller ,  Leila G. Smith

发明人： Ryan T. Koehler ,  Kenneth J. Livak ,  Junko Stevens ,  Francisco M. De La Vega ,  Michael Rhodes ,  Laurent R. Bellon ,  Julie Williams ,  Dennis A. Gilbert ,  Charles R. Scafe ,  Hadar I. Avi-Itzhak ,  Lily Xu ,  Susan Eddins ,  Michael W. Hunkapiller ,  Leila G. Smith

IPC分类号： G06Q30/00

CPC分类号： C12Q1/6858 ,  B01L3/545 ,  B01L3/5453 ,  B01L2300/021 ,  C12Q2600/156 ,  G01N35/00663 ,  G06Q30/0621 ,  G06Q30/0633 ,  G06Q30/0641 ,  G06Q50/22 ,  G16B25/00 ,  G16B30/00 ,  G16B35/00 ,  G16B45/00 ,  G16B50/00 ,  G16C20/60 ,  C12Q2547/101

摘要： Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer.

摘要翻译： 提供了检测SNP或基因表达的排序方法和系统。 方法采用PCR和RT-PCR方法。 库存测定的集合使用制造前和制造后质量控制程序组装，并通过互联网提供给消费者。 此外，根据消费者的命令制备定制测定，并且还使用制造前和制造后质量控制程序制备这些测定。 然后将测定物递送给消费者。

公开(公告)号：US20070020638A1

公开(公告)日：2007-01-25

申请号：US11083416

申请日：2005-03-18

申请人： Mike Owen ,  Julie Williams ,  Michael O'Donovan ,  Denise Harold ,  Simon Lovestone

发明人： Mike Owen ,  Julie Williams ,  Michael O'Donovan ,  Denise Harold ,  Simon Lovestone

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The invention relates to variants of the ADAM12 gene and the role these variants have to play in the diagnosis and treatment of a number of conditions including cancer, disorders of myogenesis, adipogenesis, cardiac hypertrophy and Alzheimer's disease, and in particular, Late Onset Alzheimer's Disease.

摘要翻译： 本发明涉及ADAM12基因的变体以及这些变体在诊断和治疗许多病症，包括癌症，造血障碍，脂肪形成，心脏肥大和阿尔茨海默氏病，特别是晚期阿尔茨海默病中必须发挥的作用 。

公开(公告)号：US20240008469A1

公开(公告)日：2024-01-11

申请号：US18367178

申请日：2023-09-12

申请人： Bryan E. Kilbey ,  Julie Williams

发明人： Bryan E. Kilbey ,  Julie Williams

IPC分类号： A01L15/00 ,  A01K13/00 ,  A61D9/00

CPC分类号： A01L15/00 ,  A01K13/007 ,  A61D9/00

摘要： A modular lower leg and hoof wrap configured to hold one or more therapeutic devices proximate an animal's hoof. The invention is intended primarily for use with horses. The components attach to a sole, which is intended to be positioned beneath the animal's hoof. One or more retention panels extend upward from the sole. A first wrap panel and a second wrap panel also extend upward form the sole. Elastic and VELCRO attachment features are preferably used so that each of the components may be positioned in a suitable location for a particular animal's anatomy. Other closure devices, such as buckles or snaps, could also be used.

公开(公告)号：US20170086446A1

公开(公告)日：2017-03-30

申请号：US14866057

申请日：2015-09-25

申请人： Bryan E. Kilbey ,  Julie Williams

发明人： Bryan E. Kilbey ,  Julie Williams

IPC分类号： A01L15/00 ,  A61D9/00 ,  A61D7/00 ,  A01K13/00

CPC分类号： A01L15/00 ,  A01K13/007 ,  A61D7/00 ,  A61D9/00

摘要： A modular lower leg and hoof wrap configured to hold one or more therapeutic devices proximate an animal's hoof. The invention is intended primarily for use with horses. The components attach to a sole, which is intended to be positioned beneath the animal's hoof. One or more retention panels extend upward from the sole. A first wrap panel and a second wrap panel also extend upward form the sole. Elastic and VELCRO attachment features are preferably used so that each of the components may be positioned in a suitable location for a particular animal's anatomy. Other closure devices, such as buckles or snaps, could also be used.

公开(公告)号：US11751553B2

公开(公告)日：2023-09-12

申请号：US17354070

申请日：2021-06-22

申请人： Bryan E. Kilbey ,  Julie Williams

发明人： Bryan E. Kilbey ,  Julie Williams

IPC分类号： A01L15/00 ,  A01K13/00 ,  A61D9/00 ,  A61D7/00

CPC分类号： A01L15/00 ,  A01K13/007 ,  A61D7/00 ,  A61D9/00

摘要： A modular lower leg and hoof wrap configured to hold one or more therapeutic devices proximate an animal's hoof. The invention is intended primarily for use with horses. The components attach to a sole, which is intended to be positioned beneath the animal's hoof. One or more retention panels extend upward from the sole. A first wrap panel and a second wrap panel also extend upward form the sole. Elastic and VELCRO attachment features are preferably used so that each of the components may be positioned in a suitable location for a particular animal's anatomy. Other closure devices, such as buckles or snaps, could also be used.

公开(公告)号：US20210307310A1

公开(公告)日：2021-10-07

申请号：US17354070

申请日：2021-06-22

申请人： Bryan E. Kilbey ,  Julie Williams

发明人： Bryan E. Kilbey ,  Julie Williams

IPC分类号： A01L15/00 ,  A01K13/00 ,  A61D9/00 ,  A61D7/00

摘要： A modular lower leg and hoof wrap configured to hold one or more therapeutic devices proximate an animal's hoof. The invention is intended primarily for use with horses. The components attach to a sole, which is intended to be positioned beneath the animal's hoof. One or more retention panels extend upward from the sole. A first wrap panel and a second wrap panel also extend upward form the sole. Elastic and VELCRO attachment features are preferably used so that each of the components may be positioned in a suitable location for a particular animal's anatomy. Other closure devices, such as buckles or snaps, could also be used.

公开(公告)号：US09464320B2

公开(公告)日：2016-10-11

申请号：US13458879

申请日：2012-04-27

申请人： Ryan T. Koehler ,  Kenneth J. Livak ,  Junko Stevens ,  Francisco M. De La Vega ,  Michael Rhodes ,  Laurent R. Bellon ,  Julie Williams ,  Dawn Madden ,  Dennis A. Gilbert ,  Yu N. Wang ,  Eugene G. Spier ,  Xiaoqing You ,  Lily Xu ,  Jeremy Heil ,  Stephen Glanowski ,  Emily S. Winn-Deen ,  Ivy McMullen ,  Leila G. Smith

发明人： Ryan T. Koehler ,  Kenneth J. Livak ,  Junko Stevens ,  Francisco M. De La Vega ,  Michael Rhodes ,  Laurent R. Bellon ,  Julie Williams ,  Dawn Madden ,  Dennis A. Gilbert ,  Yu N. Wang ,  Eugene G. Spier ,  Xiaoqing You ,  Lily Xu ,  Jeremy Heil ,  Stephen Glanowski ,  Emily S. Winn-Deen ,  Ivy McMullen ,  Leila G. Smith

IPC分类号： G06F19/00 ,  C12N15/11 ,  C12Q1/68 ,  G06F19/28 ,  G06Q30/06 ,  G06Q50/22 ,  G06F19/20 ,  G06F19/22 ,  G06F19/26

CPC分类号： C12Q1/6858 ,  B01L3/545 ,  B01L3/5453 ,  B01L2300/021 ,  C12Q2600/156 ,  C40B50/02 ,  G01N35/00663 ,  G06F19/20 ,  G06F19/22 ,  G06F19/26 ,  G06F19/28 ,  G06Q30/0621 ,  G06Q30/0633 ,  G06Q30/0641 ,  G06Q50/22 ,  C12Q2547/101

摘要： Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer.

摘要翻译： 提供了检测SNP或基因表达的排序方法和系统。 方法采用PCR和RT-PCR方法。 库存测定的集合使用制造前和制造后质量控制程序组装，并通过互联网提供给消费者。 此外，根据消费者的命令制备定制测定，并且还使用制造前和制造后质量控制程序制备这些测定。 然后将测定物递送给消费者。

公开(公告)号：US20120303472A1

公开(公告)日：2012-11-29

申请号：US13458879

申请日：2012-04-27

申请人： Ryan T. KOEHLER ,  Kenneth J. LIVAK ,  Junko STEVENS ,  Francisco M. DE LA VEGA ,  Michael RHODES ,  Laurent R. BELLON ,  Janet S. ZIEGLE ,  Julie WILLIAMS ,  Dawn MADDEN ,  Dennis A. GILBERT ,  Charles R. SCAFE ,  Hadar I. Isaac ,  Yu N. WANG ,  Eugene G. SPIER ,  Xiaoqing YOU ,  Lily XU ,  Jeremy HEIL ,  Stephen GLANOWSKI ,  John SCOTT ,  Emily S. WINN-DEEN ,  Ivy MCMULLEN ,  Lini WU ,  Harold Carey GIRE ,  Michael W. HUNKAPILLER ,  Susan EDDINS ,  Leila G. SMITH

发明人： Ryan T. KOEHLER ,  Kenneth J. LIVAK ,  Junko STEVENS ,  Francisco M. DE LA VEGA ,  Michael RHODES ,  Laurent R. BELLON ,  Janet S. ZIEGLE ,  Julie WILLIAMS ,  Dawn MADDEN ,  Dennis A. GILBERT ,  Charles R. SCAFE ,  Hadar I. Isaac ,  Yu N. WANG ,  Eugene G. SPIER ,  Xiaoqing YOU ,  Lily XU ,  Jeremy HEIL ,  Stephen GLANOWSKI ,  John SCOTT ,  Emily S. WINN-DEEN ,  Ivy MCMULLEN ,  Lini WU ,  Harold Carey GIRE ,  Michael W. HUNKAPILLER ,  Susan EDDINS ,  Leila G. SMITH

IPC分类号： G06Q30/06

CPC分类号： C12Q1/6858 ,  B01L3/545 ,  B01L3/5453 ,  B01L2300/021 ,  C12Q2600/156 ,  C40B50/02 ,  G01N35/00663 ,  G06F19/20 ,  G06F19/22 ,  G06F19/26 ,  G06F19/28 ,  G06Q30/0621 ,  G06Q30/0633 ,  G06Q30/0641 ,  G06Q50/22 ,  C12Q2547/101

摘要： Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer.

摘要翻译： 提供了检测SNP或基因表达的排序方法和系统。 方法采用PCR和RT-PCR方法。 库存测定的集合使用制造前和制造后质量控制程序组装，并通过互联网提供给消费者。 此外，根据消费者的命令制备定制测定，并且还使用制造前和制造后质量控制程序制备这些测定。 然后将测定物递送给消费者。

公开(公告)号：US20120122703A1

公开(公告)日：2012-05-17

申请号：US13376485

申请日：2010-06-22

申请人： Julie Williams ,  Michael John Owen

发明人： Julie Williams ,  Michael John Owen

IPC分类号： C40B20/02 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/156 ,  G01N33/6896 ,  G01N2333/775 ,  G01N2800/2821

摘要： The invention relates to novel variants that associate with Alzheimer's disease AD and their use in kits as a means for diagnosing AD; and also their use in nucleic acid molecules or cells/cell lines for identifying novel therapeutic, label of identification means.

摘要翻译： 本发明涉及与阿尔茨海默病AD相关的新型变体及其在试剂盒中的用途作为诊断AD的手段; 以及它们在核酸分子或细胞/细胞系中的用途，用于鉴定新的治疗，鉴定手段的标签。