公开(公告)号：US09683216B2

公开(公告)日：2017-06-20

申请号：US13299748

申请日：2011-11-18

申请人： Jung-Woog Shin ,  Dong-Hwa Kim

发明人： Jung-Woog Shin ,  Dong-Hwa Kim

IPC分类号： C12N5/071 ,  A61F2/06

CPC分类号： C12N5/0691 ,  A61F2/062 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/165 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2501/91 ,  C12N2506/1353 ,  C12N2521/00 ,  C12N2527/00 ,  C12N2533/30 ,  C12N2533/40

摘要： The present invention relates to a method for preparation of an artificial blood vessel using a tube-type porous biodegradable scaffold having a double layered structure and a stem cell, and an artificial blood vessel made by the same. Specifically, the present invention relates to a method for preparation of an artificial blood vessel by separately seeding a stem cell onto the inner membrane and an outer membrane of a tube-type porous biodegradable scaffold having a double layered structure, wherein the inner membrane and the outer membrane having different biodegradable polymer nano-fiber arrangements are continuously linked, and by inducing differentiation; and an artificial blood vessel made by the same.

公开(公告)号：US20120253456A1

公开(公告)日：2012-10-04

申请号：US13299748

申请日：2011-11-18

申请人： Jung-Woog SHIN ,  Dong-Hwa KIM

发明人： Jung-Woog SHIN ,  Dong-Hwa KIM

IPC分类号： A61F2/82 ,  C12N5/0789 ,  C12N5/0735 ,  C12N5/071 ,  C12N5/0775

CPC分类号： C12N5/0691 ,  A61F2/062 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/165 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2501/91 ,  C12N2506/1353 ,  C12N2521/00 ,  C12N2527/00 ,  C12N2533/30 ,  C12N2533/40

摘要： The present invention relates to a method for preparation of an artificial blood vessel using a tube-type porous biodegradable scaffold having a double layered structure and a stem cell, and an artificial blood vessel made by the same. Specifically, the present invention relates to a method for preparation of an artificial blood vessel by separately seeding a stem cell onto the inner membrane and an outer membrane of a tube-type porous biodegradable scaffold having a double layered structure, wherein the inner membrane and the outer membrane having different biodegradable polymer nano-fiber arrangements are continuously linked, and by inducing differentiation; and an artificial blood vessel made by the same.

摘要翻译： 本发明涉及使用具有双层结构的管型多孔生物可降解支架和干细胞以及由其制造的人造血管来制备人造血管的方法。 具体地说，本发明涉及一种通过将干细胞单独接种到内膜上的人造血管的制备方法和具有双层结构的管型多孔生物降解性支架的外膜，其中，内膜和 具有不同生物降解性聚合物纳米纤维排列的外膜连续连接，并通过诱导分化; 和由其制成的人造血管。

公开(公告)号：US09681953B2

公开(公告)日：2017-06-20

申请号：US14006401

申请日：2012-02-20

申请人： Jung Woog Shin ,  Ji Won Shin ,  So Hee Park

发明人： Jung Woog Shin ,  Ji Won Shin ,  So Hee Park

IPC分类号： A61F2/28 ,  A61L27/12 ,  A61L27/56 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58 ,  A61F2/30

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2002/30766 ,  A61L27/12 ,  A61L27/3817 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/02 ,  A61L2430/06

摘要： The present invention relates to a complex support body for regenerating bone-cartilage, a method for manufacturing thereof, and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient, and more particularly, to a complex support body for regenerating bone-cartilage, which comprises a bone regeneration layer consisting of a biodegradable polymer and a biocompatible ceramic, and a cartilage regeneration layer, which is coupled to the bone regeneration layer and in which cells that can be differentiated into cartilages cells are fixed; a method for manufacturing thereof; and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient. The complex support body of the present invention for regenerating bone-cartilage is manufactured as a three-dimensional support body, which is similar to a living tissue, according to a bioplotting method, and exerts the effect of regeneration into a bone tissue and a cartilage tissue, respectively, depending on materials encountered in the environment where the complex support body for regenerating bone-cartilage is used.

公开(公告)号：US20140012393A1

公开(公告)日：2014-01-09

申请号：US14006401

申请日：2012-02-20

申请人： Jung Woog Shin ,  Ji Won Shin ,  So Hee Park

发明人： Jung Woog Shin ,  Ji Won Shin ,  So Hee Park

IPC分类号： A61F2/28

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2002/30766 ,  A61L27/12 ,  A61L27/3817 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/02 ,  A61L2430/06

摘要： The present invention relates to a complex support body for regenerating bone-cartilage, a method for manufacturing thereof, and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient, and more particularly, to a complex support body for regenerating bone-cartilage, which comprises a bone regeneration layer consisting of a biodegradable polymer and a biocompatible ceramic, and a cartilage regeneration layer, which is coupled to the bone regeneration layer and in which cells that can be differentiated into cartilages cells are fixed; a method for manufacturing thereof; and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient. The complex support body of the present invention for regenerating bone-cartilage is manufactured as a three-dimensional support body, which is similar to a living tissue, according to a bioplotting method, and exerts the effect of regeneration into a bone tissue and a cartilage tissue, respectively, depending on materials encountered in the environment where the complex support body for regenerating bone-cartilage is used.

摘要翻译： 本发明涉及一种用于再生骨软骨的复合体支撑体，其制造方法和用于治疗骨和软骨相关疾病的组合物，其包含其作为活性成分，更具体地涉及一种用于再生的复合体 骨软骨，其包含由生物可降解聚合物和生物相容性陶瓷组成的骨再生层，和软骨再生层，其与骨再生层连接，其中可分化成软骨细胞的细胞被固定; 其制造方法; 以及用于治疗骨和软骨相关疾病的组合物，其包含其作为活性成分。 根据生物绘图方法，本发明的用于再生骨软骨的复合支撑体被制造为与生物体组织相似的三维支撑体，并且将再生的效果发挥到骨组织和软骨中 组织，这取决于在使用用于再生骨软骨的复合体支撑体的环境中遇到的材料。