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    Materials And Methods For Treating Coagulation Disorders
    6.
    发明申请
    Materials And Methods For Treating Coagulation Disorders 审中-公开
    治疗凝血障碍的材料和方法

    公开(公告)号：US20070129429A1

    公开(公告)日：2007-06-07

    申请号：US11551302

    申请日：2006-10-20

    申请人： Pascal Druzgala ,  Xiaoming Zhang ,  Jurg Pfister

    发明人： Pascal Druzgala ,  Xiaoming Zhang ,  Jurg Pfister

    IPC分类号： A61K31/366 ,  C07D405/02

    CPC分类号： A61K31/366 ,  A61K31/37 ,  C07D311/56

    摘要： This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

    摘要翻译： 本发明涉及更容易被代谢药物解毒系统代谢的化合物。 特别地，教导了被设计成在化合物的结构内包含酯的华法林类似物。 本发明教导了在药物合成期间降低包括将酯基引入药物的药物的毒性的方法。 本发明还涉及治疗凝血障碍的方法，其包括施用被设计为由血清或细胞内水解酶和酯酶代谢的化合物。 还教导了含有华法林酯类药物组合物。

    Materials and methods for the treatment of gastroesophageal reflux disease
    7.
    再颁专利
    Materials and methods for the treatment of gastroesophageal reflux disease 有权
    用于治疗胃食管反流病的材料和方法

    公开(公告)号：USRE42412E1

    公开(公告)日：2011-05-31

    申请号：US11962592

    申请日：2007-12-21

    申请人： Pascal Druzgala ,  Peter G. Milner ,  Jurg Pfister ,  Cyrus Becker

    发明人： Pascal Druzgala ,  Peter G. Milner ,  Jurg Pfister ,  Cyrus Becker

    IPC分类号： A61K31/445 ,  C07D211/56

    CPC分类号： C07D211/58 ,  A61K31/4468 ,  C07D211/46

    摘要： The subject invention provides novel compounds and compositions for the safe and effective treatment of gastroesophageal reflux and related conditions. In a preferred embodiment, the compositions of the subject invention comprise esterified cisapride derivatives. These compositions possess potent activity in treating gastroesophageal reflux disease and substantially reduce adverse effects associated with the administration of cisapride. These adverse effects include, but are not limited to, diarrhea, abdominal cramping and elevations of blood pressure and heart rate.

    摘要翻译： 本发明提供了用于安全有效地治疗胃食管反流和相关病症的新型化合物和组合物。 在优选的实施方案中，本发明的组合物包含酯化的西沙必利衍生物。 这些组合物在治疗胃食管反流疾病中具有有效的活性，并且显着减少与西沙必利施用相关的不良反应。 这些不良影响包括但不限于腹泻，腹部绞痛和血压升高和心率升高。

    Coupling device for making a permanent pipe connection
    9.
    发明授权
    Coupling device for making a permanent pipe connection 失效
    用于制造永久性管道连接的联接装置

    公开(公告)号：US4598938A

    公开(公告)日：1986-07-08

    申请号：US717229

    申请日：1985-03-18

    申请人： Hans Boss ,  Jurg Pfister, deceased ,  by Lisa Pfister, administrator

    发明人： Hans Boss ,  Jurg Pfister, deceased ,  by Lisa Pfister, administrator

    IPC分类号： B21D39/04 ,  F16L20060101 ,  F16L13/14 ,  F16L21/04

    CPC分类号： F16L13/146 ,  B21D39/04 ,  Y10T29/49913 ,  Y10T29/49934

    摘要： In this pipe connection, the pipe end part (5) is pressed, as a result of cold-forming in zones, by means of a press ring (4) to be displaced axially, to form a positive leak-proof connection with a connection piece (1) inserted into the pipe end part and belonging to a pipe fitting (2). A sleeve (3) to be pushed onto the pipe end part is provided with an annular outer bead (7) and, when the press ring is pressed on, is deformed in such a way that the sleeve material is displaced radially inwards in the bead zone (8), the pipe end part and connection piece acquiring an annular recess (9). Moreover, the press ring (4) has at its rear end an annular inner bead (10) which at the same time displaces the sleeve material radially inwards at the rear sleeve end, as a result of which further pressing takes place at the end (12) of the connection piece (1). The gap between the pipe and connection piece is thus closed, so that no crevice corrosion can occur.

    摘要翻译： PCT No.PCT / CH84 / 00114 Sec。 371日期1985年3月18日 102（e）1985年3月18日PCT提交1984年7月12日PCT公布。 出版物WO85 / 00646 日期为1985年2月14日。在该管道连接中，由于在区域中冷成型，管端部（5）通过压环（4）被轴向移动，以形成正的 与插入管端部并属于管接头（2）的连接件（1）的防漏连接。 被推入管端部的套筒（3）设置有环形外胎圈（7），并且当按压环时，其变形使得套筒材料在胎圈中径向向内位移 （8），管端部和连接件获取环形凹部（9）。 此外，压环（4）在其后端处具有环形内胎圈（10），其同时在后套筒端部沿径向向内移动套筒材料，由此在末端进一步压紧（ 12）。 因此，管和连接件之间的间隙被封闭，从而不会发生缝隙腐蚀。