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1.发明申请公开(公告)号：US20160113920A1
公开(公告)日：2016-04-28
申请号：US14922114
申请日：2015-10-23
IPC分类号： A61K31/4706 , A61K45/06 , A61K31/131
CPC分类号： A61K31/4706 , A61K31/131 , A61K45/06 , A61K2300/00
摘要： Compositions and methods including Amodiaquine (AQ) or N-Desethy Amodiaquine (DEAQ) are provided for treating, inhibiting, or preventing cathepsin B dependent pathogens and toxins in a host cell or infected subject. Compositions and methods also include AQ or DEAQ in combination with an antibiotic for more effective clearance of the pathogen and/or toxins.
摘要翻译： 提供包括阿莫地喹（AQ）或N-去乙基阿莫地喹（DEAQ）的组合物和方法用于治疗，抑制或预防宿主细胞或感染受试者中组织蛋白酶B依赖性病原体和毒素。 组合物和方法还包括与抗生素组合的AQ或DEAQ，以更有效地清除病原体和/或毒素。
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公开(公告)号：US20130291965A1
公开(公告)日：2013-11-07
申请号：US13859680
申请日：2013-04-09
发明人： Anna Hickerson
IPC分类号： F16K15/00
CPC分类号： F16K15/00 , F16K15/142 , Y10T137/7837
摘要： A valve has a generally hollow core with one open end and one closed end, and at least one side port in a sidewall of the core. The valve also includes a sleeve that fits over the core and covers the side port(s). The cracking pressure of the valve is tunable by varying the parameters of the sleeve.
摘要翻译： 阀具有通常为中空的芯，其具有一个开口端和一个封闭端，以及在该芯的侧壁中的至少一个侧端口。 该阀还包括套筒，该套筒套在芯部上并覆盖侧面端口。 阀的开启压力可通过改变套筒的参数来调节。
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公开(公告)号：US20200308593A1
公开(公告)日：2020-10-01
申请号：US16804305
申请日：2020-02-28
IPC分类号： C12N15/81
摘要： In accordance with the invention, isolated nucleic acids, expression methods, host cells, expression vectors, and DNA constructs for producing proteins, and proteins produced using the expression methods are described. More particularly, nucleic acids isolated from Pichia pastoris wherein the nucleic acids have promoter activity are described. The invention also relates to expression methods, host cells, expression vectors, and DNA constructs, for using the Pichia pastoris promoters to produce proteins, and to the proteins produced using the expression methods.
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公开(公告)号：US10369119B2
公开(公告)日：2019-08-06
申请号：US15770142
申请日：2016-10-21
IPC分类号： A61K31/10 , A61P31/14 , A61P31/04 , A61K38/14 , A61K45/06 , A61K31/4164 , A61K31/43 , A61K31/496 , A61K31/546 , A61K31/65 , A61K31/7048 , A61K31/7056 , A61K31/131
摘要： Compositions and methods including Bithionol are provided for treating, inhibiting, or preventing caspase-dependent pathogenic agents in a host cell or infected subject. Examples of caspase-dependent pathogenic agents include ricin, anthrax toxin, Botulinum neurotoxin A, diphtheria toxin, Pseudomonas aeruginosa exotoxin A, cholera toxin, Zika virus, and combinations thereof. Compositions and methods also include Bithionol in combination with an antibiotic for more effective clearance of the pathogen and/or toxins.
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公开(公告)号：US20180303769A1
公开(公告)日：2018-10-25
申请号：US15770142
申请日：2016-10-21
CPC分类号： A61K31/10 , A61K31/131 , A61K31/4164 , A61K31/43 , A61K31/496 , A61K31/546 , A61K31/65 , A61K31/7048 , A61K31/7056 , A61K38/14 , A61K45/06 , A61K2300/00 , A61P31/04 , A61P31/14 , Y02A50/391 , Y02A50/469
摘要： Compositions and methods including Bithionol are provided for treating, inhibiting, or preventing caspase-dependent pathogenic agents in a host cell or infected subject. Examples of caspase-dependent pathogenic agents include ricin, anthrax toxin, Botulinum neurotoxin A, diphtheria toxin, Pseudomonas aeruginosa exotoxin A, cholera toxin, Zika virus, and combinations thereof. Compositions and methods also include Bithionol in combination with an antibiotic for more effective clearance of the pathogen and/or toxins.
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公开(公告)号：US20180023121A1
公开(公告)日：2018-01-25
申请号：US15699718
申请日：2017-09-08
发明人： Angelika Niemz , Anna Hickerson , Kristina Roskos , Hsiang-Wei Lu
CPC分类号： C12Q1/686 , B01L3/502723 , B01L3/50273 , B01L7/00 , B01L2300/0663 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , F04B17/00
摘要： A disposable and inexpensive biological diagnostic cartridge for the amplification and detection of nucleic acids includes a configuration having a reaction pouch for amplification which is compressed by a flexible pump pouch for detection of the amplified reaction.
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公开(公告)号：US09797006B2
公开(公告)日：2017-10-24
申请号：US13860453
申请日：2013-04-10
发明人： Angelika Niemz , Anna Hickerson , Kristina Roskos , Hsiang-Wei Lu
CPC分类号： C12Q1/686 , B01L3/502723 , B01L3/50273 , B01L7/00 , B01L2300/0663 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , F04B17/00
摘要： A disposable and inexpensive biological diagnostic cartridge for the amplification and detection of nucleic acids includes a configuration having a reaction pouch for amplification which is compressed by a flexible pump pouch for detection of the amplified reaction.
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公开(公告)号：US20210355498A1
公开(公告)日：2021-11-18
申请号：US17180430
申请日：2021-02-19
IPC分类号： C12N15/81
摘要： In accordance with the invention, isolated nucleic acids, expression methods, host cells, expression vectors, and DNA constructs for producing proteins, and proteins produced using the expression methods are described. More particularly, nucleic acids isolated from Pichia pastoris wherein the nucleic acids have promoter activity are described. The invention also relates to expression methods, host cells, expression vectors, and DNA constructs, for using the Pichia pastoris promoters to produce proteins, and to the proteins produced using the expression methods.
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公开(公告)号：US20160097053A1
公开(公告)日：2016-04-07
申请号：US14773474
申请日：2014-03-07
IPC分类号： C12N15/81
CPC分类号： C12N15/815 , C12N15/81
摘要： In accordance with the invention, isolated nucleic acids, expression methods, host cells, expression vectors, and DNA constructs for producing proteins, and proteins produced using the expression methods are described. More particularly, nucleic acids isolated from Pichia pastoris wherein the nucleic acids have promoter activity are described. The invention also relates to expression methods, host cells, expression vectors, and DNA constructs, for using the Pichia pastoris promoters to produce proteins, and to the proteins produced using the expression methods.
摘要翻译： 根据本发明，描述了使用表达方法产生的分离的核酸，表达方法，宿主细胞，表达载体和用于产生蛋白质的DNA构建体和蛋白质。 更具体地，描述了从巴斯德毕赤酵母中分离的核酸，其中核酸具有启动子活性。 本发明还涉及使用巴斯德毕赤酵母启动子产生蛋白质的表达方法，宿主细胞，表达载体和DNA构建体，以及使用表达方法产生的蛋白质。
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10.发明申请Human tyrosine-DNA phosphodiesterase variant polypeptides and methods of use therefor 失效人酪氨酸-DNA磷酸二酯酶变体多肽及其用途的方法公开(公告)号：US20030124587A1
公开(公告)日：2003-07-03
申请号：US10265012
申请日：2002-10-04
发明人： Chen-Chen Kan , Ting-Jen Cheng
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/16 , C12P021/02 , C12N005/06
摘要： The present invention provides human tyrosine-DNA phosphodiesterases (TDPs). In particular, the present invention provides novel recombinant nucleic acids and proteins, including mutant TDPs, vectors, and TDP-producing cells, as well as co-factors for enzyme activity. The present invention further provides methods for high through-put enzymatic assay systems utilizing the TDPs of the present invention.
摘要翻译： 本发明提供人酪氨酸 - 磷酸二酯酶（TDP）。 特别地，本发明提供新的重组核酸和蛋白质，包括突变体TDP，载体和产生TDP的细胞，以及酶活性的辅因子。 本发明还提供了利用本发明的TDP的高通量酶分析系统的方法。
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