公开(公告)号：US20100268106A1

公开(公告)日：2010-10-21

申请号：US12761290

申请日：2010-04-15

申请人： Bradley N. Johnson ,  Kanchan Joshi ,  Ying-Lan Chang ,  Ray Radtkey

发明人： Bradley N. Johnson ,  Kanchan Joshi ,  Ying-Lan Chang ,  Ray Radtkey

IPC分类号： A61B5/097

CPC分类号： A61B5/097 ,  A61B5/0803 ,  A61B5/082 ,  A61B5/14539 ,  B82Y30/00 ,  G01N33/497 ,  G01N2001/2282

摘要： The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate/breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.

摘要翻译： 本发明提供了一种用于呼出凝结水中分析物的直接取样器和检测器。 呼吸冷凝液中的分析物在到达传感器表面之前凝结，或者直接凝结在传感器表面上瞬间被检测到。 因为在患者呼气后立即进行分析或测定，所以分析物的稳定性得到显着改善，可提供准确，可靠，一致和临床适用的结果。 在某些实施方案中，提供组合的呼吸冷凝物/呼吸取样器和检测器，使得能够对在单个采样会话中提供的冷凝和气相分析物进行复用分析。 呼吸被收集并引导到一个或多个子系统。 在每个子系统内，呼吸部分被冷凝或防止冷凝。 该技术还允许实时连续监测，从而允许立即反馈医疗专业人员和附加硬件，如呼吸机，麻醉机，药物输注系统和心脏起搏器。

公开(公告)号：US09357946B2

公开(公告)日：2016-06-07

申请号：US12761290

申请日：2010-04-15

申请人： Bradley N. Johnson ,  Kanchan Joshi ,  Ying-Lan Chang ,  Ray Radtkey

发明人： Bradley N. Johnson ,  Kanchan Joshi ,  Ying-Lan Chang ,  Ray Radtkey

IPC分类号： A61B5/08 ,  A61B5/097 ,  A61B5/145 ,  B82Y30/00 ,  G01N33/497 ,  G01N1/22

CPC分类号： A61B5/097 ,  A61B5/0803 ,  A61B5/082 ,  A61B5/14539 ,  B82Y30/00 ,  G01N33/497 ,  G01N2001/2282

摘要： The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate/breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.

摘要翻译： 本发明提供了一种用于呼出凝结水中分析物的直接取样器和检测器。 呼吸冷凝液中的分析物在到达传感器表面之前凝结，或者直接凝结在传感器表面上瞬间被检测到。 因为在患者呼气后立即进行分析或测定，所以分析物的稳定性得到显着改善，可提供准确，可靠，一致和临床适用的结果。 在某些实施方案中，提供组合的呼吸冷凝物/呼吸取样器和检测器，使得能够对在单个采样会话中提供的冷凝和气相分析物进行复用分析。 呼吸被收集并引导到一个或多个子系统。 在每个子系统内，呼吸部分被冷凝或防止冷凝。 该技术还允许实时连续监测，从而允许立即反馈医疗专业人员和附加硬件，如呼吸机，麻醉机，药物输注系统和心脏起搏器。

公开(公告)号：US08993346B2

公开(公告)日：2015-03-31

申请号：US13389247

申请日：2010-08-06

申请人： Ray Radtkey ,  Kanchan Joshi ,  Bradley N. Johnson ,  Ying-Lan Chang

发明人： Ray Radtkey ,  Kanchan Joshi ,  Bradley N. Johnson ,  Ying-Lan Chang

IPC分类号： G01N33/563 ,  G01N33/553 ,  G01N33/543 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/02 ,  G01N27/22

CPC分类号： G01N33/5438 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/16 ,  C01B32/162 ,  C01B32/174 ,  G01N27/226

摘要： Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.

摘要翻译： 本文提供了一种新的混合材料系统，mCNT，包括用于生物和医学感测应用的磁性碳纳米管。 在某些实施例中，系统包括在碳纳米管（CNT）内部的磁性材料。 碳纳米管内的磁性颗粒的量可以使得mCNT可以响应于小型，低成本的便携式磁体。 外部CNT表面保持完整，用于生物分子附着或其他功能化。 这种新型材料的性能增强包括改进的灵敏度，减少的响应时间和减少的样品体积。 根据各种实施方案，mCNT是用于粘附参与这些测定的分子或作为主动感测元件的底物。 还提供了在印刷电极上制造二维mCNT和CNT网络的方法。

公开(公告)号：US20120178187A1

公开(公告)日：2012-07-12

申请号：US13389247

申请日：2010-08-06

申请人： Ray Radtkey ,  Kanchan Joshi ,  Bradley N. Johnson ,  Ying-Lan Chang

发明人： Ray Radtkey ,  Kanchan Joshi ,  Bradley N. Johnson ,  Ying-Lan Chang

IPC分类号： G01N33/551 ,  B82Y5/00

CPC分类号： G01N33/5438 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/16 ,  C01B32/162 ,  C01B32/174 ,  G01N27/226

摘要： Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.

摘要翻译： 本文提供了一种新的混合材料系统，mCNT，包括用于生物和医学感测应用的磁性碳纳米管。 在某些实施例中，系统包括在碳纳米管（CNT）内部的磁性材料。 碳纳米管内的磁性颗粒的量可以使得mCNT可以响应于小型，低成本的便携式磁体。 外部CNT表面保持完整，用于生物分子附着或其他功能化。 这种新型材料的性能增强包括改进的灵敏度，减少的响应时间和减少的样品体积。 根据各种实施方案，mCNT是用于粘附参与这些测定的分子或作为主动感测元件的底物。 还提供了在印刷电极上制造二维mCNT和CNT网络的方法。