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公开(公告)号：US20090191208A1
公开(公告)日：2009-07-30
申请号：US12231777
申请日：2008-09-05
IPC分类号： A61K39/395 , C07K16/12
CPC分类号： C07K16/1235 , A61K2039/505 , A61K2039/545 , C07K16/1214 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , Y02A50/403 , Y02A50/407 , Y02A50/484
摘要： The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
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公开(公告)号：US08263078B2
公开(公告)日：2012-09-11
申请号：US12231797
申请日：2008-09-05
IPC分类号： A61K39/00 , A61K39/38 , A61K39/40 , A61K39/395 , C07K16/00
CPC分类号： C07K16/1235 , A61K2039/505 , A61K2039/545 , C07K16/1214 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , Y02A50/403 , Y02A50/407 , Y02A50/484
摘要： The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
摘要翻译： 本发明提供了一种新型的单克隆抗体，其具有与来自各种革兰氏阴性细菌的鞭毛蛋白的高亲和力，广谱中和反应性，包括但不限于大肠杆菌，沙门氏菌，沙雷氏菌属，变形杆菌属，肠杆菌属，柠檬酸杆菌属，弯曲杆菌属 和假单胞菌属。 本发明还提供了治疗炎症性肠病（IBD）的方法和使用人，其他动物和鸟类中的抗鞭毛蛋白抗体治疗肠细菌感染的方法。
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公开(公告)号：US20100239583A1
公开(公告)日：2010-09-23
申请号：US12717351
申请日：2010-03-04
IPC分类号： A61K39/395 , C07K16/12 , C07K16/46 , C12N5/16 , C07H21/04 , C12N15/13 , A01N63/02 , A01P1/00 , A61P31/04 , A61P31/08 , A61P31/06 , A61P13/02 , A61P7/00 , G01N33/53
CPC分类号： G01N33/56916 , C07K16/1203 , C07K16/1235 , C07K2317/34 , C07K2317/76 , Y02A50/56 , Y02A50/57 , Y02A50/59
摘要： The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating infections and diseases using anti-flagellin antibodies in humans, other animals and birds.
摘要翻译： 本发明提供了一种新型的单克隆抗体，其具有与来自各种革兰氏阴性细菌的鞭毛蛋白的高亲和力，广谱中和反应性，包括但不限于大肠杆菌，沙门氏菌，沙雷氏菌属，变形杆菌属，肠杆菌属，柠檬酸杆菌属，弯曲杆菌属 和假单胞菌属。 本发明还提供了在人，其他动物和鸟类中使用抗鞭毛蛋白抗体治疗感染和疾病的方法。
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公开(公告)号：US08173130B2
公开(公告)日：2012-05-08
申请号：US12231777
申请日：2008-09-05
IPC分类号： A61K39/00 , A61K39/38 , A61K39/40 , A61K39/395
CPC分类号： C07K16/1235 , A61K2039/505 , A61K2039/545 , C07K16/1214 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , Y02A50/403 , Y02A50/407 , Y02A50/484
摘要： The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
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公开(公告)号：US20090208506A1
公开(公告)日：2009-08-20
申请号：US12231797
申请日：2008-09-05
IPC分类号： A61K39/395 , C07K16/00 , C12N5/12 , C12N15/13 , C12N15/63
CPC分类号： C07K16/1235 , A61K2039/505 , A61K2039/545 , C07K16/1214 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , Y02A50/403 , Y02A50/407 , Y02A50/484
摘要： The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
摘要翻译： 本发明提供了一种新型的单克隆抗体，其具有与来自各种革兰氏阴性细菌的鞭毛蛋白的高亲和力，广谱中和反应性，包括但不限于大肠杆菌，沙门氏菌，沙雷氏菌属，变形杆菌属，肠杆菌属，柠檬酸杆菌属，弯曲杆菌属 和假单胞菌属。 本发明还提供了治疗炎症性肠病（IBD）的方法和使用人，其他动物和鸟类中的抗鞭毛蛋白抗体治疗肠细菌感染的方法。
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