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1.
公开(公告)号:US20140242651A1
公开(公告)日:2014-08-28
申请号:US14220301
申请日:2014-03-20
CPC分类号: C12P7/62 , C12N9/20 , C12P41/004
摘要: The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacylglycerol lipase mutants, as for example derived from Candida antarctica lipase B (CALB); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of a mutated triacylglycerol lipase in a method of preparing mono-acylated polyols. The invention also provides novel mutants, coding sequences thereof, and recombinant microorganisms carrying said coding sequences.
摘要翻译: 本发明涉及由三酰基甘油脂肪酶突变体催化的单酰化多元醇的生物催化方法,例如衍生自南极假丝酵母脂肪酶B(CALB); 通过相同的酶突变体催化的对映选择性制备不对称单酰化多元醇的生物催化方法; 以及在制备单酰化多元醇的方法中使用突变的三酰基甘油脂肪酶。 本发明还提供了新的突变体,其编码序列和携带所述编码序列的重组微生物。
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公开(公告)号:US07491836B2
公开(公告)日:2009-02-17
申请号:US10553275
申请日:2004-04-13
IPC分类号: C07C59/00
CPC分类号: A61K9/02 , A61K9/0019 , A61K9/2031 , A61K9/4866 , C08G65/3322 , C12P7/62
摘要: New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene/alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3—(CH2)x—CH—(CH2)y—CO—[—O—R3—]z—O—R1 R2—O (I); wherein for example R1 is methyl, R2 is optionally substituted C14-C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.
摘要翻译: 具有聚氧亚烷基二醇羟基脂肪酸衍生物或单烷基化聚氧亚烷基二醇羟基脂肪酸衍生物的新型非离子表面活性剂,其具有链长为25-455个重复单元的聚氧化烯/烷基聚氧化烯链和羟基位置上的特定取代基 根据通式(I)CH 3 - (CH 2)x -CH-(CH 2)y -CO - [ - O-R 3 - ] z O-R 1 R 2 -O(I)的特定羟基脂肪酸; 其中例如R 1是甲基,R 2是任选取代的C 14 -C 22酰基,烷基或烯基,R 3是亚乙基,x是2-12,y是7-17,(x + y)是3-19,z是25 -57; 有利地通过涉及酶法制备,包含它们的制剂,它们作为增溶剂的用途和涉及用于制备它们的水解酶的方法。
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公开(公告)号:US08715970B2
公开(公告)日:2014-05-06
申请号:US13496342
申请日:2010-09-16
CPC分类号: C12P7/62 , C12N9/20 , C12P41/004
摘要: The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacylglycerol lipase mutants, as for example derived from Candida antarctica lipase B (CALB); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of a mutated triacylglycerol lipase in a method of preparing mono-acylated polyols. The invention also provides novel mutants, coding sequences thereof, and recombinant microorganisms carrying said coding sequences.
摘要翻译: 本发明涉及由三酰基甘油脂肪酶突变体催化的单酰化多元醇的生物催化方法,例如衍生自南极假丝酵母脂肪酶B(CALB); 通过相同的酶突变体催化的对映选择性制备不对称单酰化多元醇的生物催化方法; 以及在制备单酰化多元醇的方法中使用突变的三酰基甘油脂肪酶。 本发明还提供了新的突变体,其编码序列和携带所述编码序列的重组微生物。
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公开(公告)号:US20120171738A1
公开(公告)日:2012-07-05
申请号:US13496342
申请日:2010-09-16
CPC分类号: C12P7/62 , C12N9/20 , C12P41/004
摘要: The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacyl-glycerol lipase mutants, as for example derived from Candida antarctica lipase B (CALB); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of a mutated triacylglycerol lipase in a method of preparing mono-acylated polyols. The invention also provides novel mutants, coding sequences thereof, and recombinant microorganisms carrying said coding sequences.
摘要翻译: 本发明涉及由三酰基甘油脂肪酶突变体催化的单酰化多元醇的生物催化方法,例如衍生自南极假丝酵母脂肪酶B(CALB); 通过相同的酶突变体催化的对映选择性制备不对称单酰化多元醇的生物催化方法; 以及在制备单酰化多元醇的方法中使用突变的三酰基甘油脂肪酶。 本发明还提供了新的突变体,其编码序列和携带所述编码序列的重组微生物。
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5.
公开(公告)号:US20060287542A1
公开(公告)日:2006-12-21
申请号:US10553275
申请日:2004-04-13
IPC分类号: C07C255/28 , C07C229/02
CPC分类号: A61K9/02 , A61K9/0019 , A61K9/2031 , A61K9/4866 , C08G65/3322 , C12P7/62
摘要: New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene / alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3—(CH2)x—CH—(CH2)y—CO—[—O—R3—]z—O—R1 R2—O (I); wherein for example R1 is methyl, R2 is optionally substituted C14—C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.
摘要翻译: 具有聚氧亚烷基二醇羟基脂肪酸衍生物或单烷基化聚氧亚烷基二醇羟基脂肪酸衍生物的新型非离子表面活性剂,其具有链长为25-455个重复单元的聚氧化烯/烷基聚氧化烯链和羟基位置上的特定取代基 指定的羟基脂肪酸,根据通式(I)CH 3 - (CH 2)x - CH-(CH - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -O(I); 其中例如R 1是甲基,R 2是任选取代的C 14 -C 22酰基,烷基, 或链烯基,R 3是亚乙基,x是2-12,y是7-17,(x + y)是3-19,z是25-57; 有利地通过涉及酶法制备,包含它们的制剂,它们作为增溶剂的用途和涉及用于制备它们的水解酶的方法。
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