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公开(公告)号：US07267823B2
公开(公告)日：2007-09-11
申请号：US10384976
申请日：2003-03-10
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2760/14022 , C12N2760/14122 , C12N2760/14134 , C12N2770/36123 , C12N2770/36143
摘要： Using CTL epitopes to the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described.
摘要翻译： 描述了使用针对埃博拉GP，NP，VP24，VP30，VP35和VP40病毒粒子蛋白的CTL表位，用于诱导免疫反应的方法和组合物，其针对埃博拉病毒感染。
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公开(公告)号：US20130184168A1
公开(公告)日：2013-07-18
申请号：US13350233
申请日：2012-01-13
IPC分类号： C40B30/04 , G01N33/566 , C07H19/207
CPC分类号： G01N33/56911 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to immunoreactive Francisella tularensis antigens and their uses as correlates of protection against tularemia. In one aspect, the invention provides a set of biomarkers for tularemia. In another aspect the invention provides a method of evaluating immunity against tularaemia in a subject, using the biomarkers.
摘要翻译： 本发明涉及免疫反应性拉曼氏菌弧菌抗原及其作为保护免受土拉热病的相关性的用途。 一方面，本发明提供了一套用于土拉热瘤的生物标志物。 在另一方面，本发明提供了一种使用生物标志物评价受试者的免疫性免疫性的方法。
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公开(公告)号：US20130036736A1
公开(公告)日：2013-02-14
申请号：US13590853
申请日：2012-08-21
申请人： Katherine Hart , Timothy James Held
发明人： Katherine Hart , Timothy James Held
IPC分类号： F01K13/02
CPC分类号： F01K13/02 , F01K3/185 , F01K11/00 , F01K25/103 , G05D7/0617
摘要： Embodiments of the invention generally provide a heat engine system, a mass management system (MMS), and a method for regulating pressure in the heat engine system while generating electricity. In one embodiment, the MMS contains a tank fluidly coupled to a pump, a turbine, a heat exchanger, an offload terminal, and a working fluid contained in the tank at a storage pressure. The working fluid may be at a system pressure proximal an outlet of the heat exchanger, at a low-side pressure proximal a pump inlet, and at a high-side pressure proximal a pump outlet. The MMS contains a controller communicably coupled to a valve between the tank and the heat exchanger outlet, a valve between the tank and the pump inlet, a valve between the tank and the pump outlet, and a valve between the tank and the offload terminal.
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公开(公告)号：US09863282B2
公开(公告)日：2018-01-09
申请号：US14469711
申请日：2014-08-27
申请人： Katherine Hart , Timothy James Held
发明人： Katherine Hart , Timothy James Held
CPC分类号： F01K13/02 , F01K3/185 , F01K11/00 , F01K25/103 , G05D7/0617
摘要： Embodiments of the invention generally provide a heat engine system, a mass management system (MMS), and a method for regulating pressure in the heat engine system while generating electricity. In one embodiment, the MMS contains a tank fluidly coupled to a pump, a turbine, a heat exchanger, an offload terminal, and a working fluid contained in the tank at a storage pressure. The working fluid may be at a system pressure proximal an outlet of the heat exchanger, at a low-side pressure proximal a pump inlet, and at a high-side pressure proximal a pump outlet. The MMS contains a controller communicably coupled to a valve between the tank and the heat exchanger outlet, a valve between the tank and the pump inlet, a valve between the tank and the pump outlet, and a valve between the tank and the offload terminal.
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公开(公告)号：US20150000281A1
公开(公告)日：2015-01-01
申请号：US14469711
申请日：2014-08-27
申请人： Katherine Hart , Timothy James Held
发明人： Katherine Hart , Timothy James Held
CPC分类号： F01K13/02 , F01K3/185 , F01K11/00 , F01K25/103 , G05D7/0617
摘要： Embodiments of the invention generally provide a heat engine system, a mass management system (MMS), and a method for regulating pressure in the heat engine system while generating electricity. In one embodiment, the MMS contains a tank fluidly coupled to a pump, a turbine, a heat exchanger, an offload terminal, and a working fluid contained in the tank at a storage pressure. The working fluid may be at a system pressure proximal an outlet of the heat exchanger, at a low-side pressure proximal a pump inlet, and at a high-side pressure proximal a pump outlet. The MMS contains a controller communicably coupled to a valve between the tank and the heat exchanger outlet, a valve between the tank and the pump inlet, a valve between the tank and the pump outlet, and a valve between the tank and the offload terminal.
摘要翻译： 本发明的实施例通常提供热发动机系统，质量管理系统（MMS）以及用于在发电时调节热机系统中的压力的方法。 在一个实施例中，MMS包含在储存压力下流体耦合到泵，涡轮机，热交换器，卸载端子和容纳在罐中的工作流体的罐。 工作流体可以处于靠近热交换器的出口处的系统压力，在泵入口附近的低侧压力处，以及在泵出口附近的高侧压力。 MMS包含可控制地耦合到罐和热交换器出口之间的阀，罐和泵入口之间的阀，罐和泵出口之间的阀以及罐和卸载端之间的阀的控制器。
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公开(公告)号：US20170362963A1
公开(公告)日：2017-12-21
申请号：US15536404
申请日：2015-12-07
申请人： Steven R. HOSTLER , Timothy HELD , Katherine HART , Jason MILLER
发明人： Steven R. Hostler , Timothy Held , Katherine Hart , Jason Miller
CPC分类号： F01K13/025 , F01D15/005 , F01D15/10 , F01D25/125 , F01K13/00 , F01K21/00 , F01K21/02 , F01K23/02 , F01K23/103 , F01K27/02 , Y02E20/14
摘要： A pressure reduction system may include an alternator with a casing and a rotor positioned, at least in part, within a cavity defined by the casing. The pressure reduction system may also include a mass management system that includes a control tank configured to be maintained at a tank pressure lower than a cavity pressure within the cavity of the alternator, thereby forming a pressure differential. A first transfer conduit may transfer a working fluid from the cavity of the alternator to the control tank via the pressure differential. The mass management system may be positioned at an elevation above the alternator, and include a refrigeration loop configured to cool the working fluid contained within the control tank. A second transfer conduit may fluidly couple the alternator and the mass management system, and may transfer the cooled working fluid from the control tank to the cavity via gravitational force.
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公开(公告)号：US08813497B2
公开(公告)日：2014-08-26
申请号：US13590853
申请日：2012-08-21
申请人： Katherine Hart , Timothy James Held
发明人： Katherine Hart , Timothy James Held
CPC分类号： F01K13/02 , F01K3/185 , F01K11/00 , F01K25/103 , G05D7/0617
摘要： Embodiments of the invention generally provide a heat engine system, a mass management system (MMS), and a method for regulating pressure in the heat engine system while generating electricity. In one embodiment, the MMS contains a tank fluidly coupled to a pump, a turbine, a heat exchanger, an offload terminal, and a working fluid contained in the tank at a storage pressure. The working fluid may be at a system pressure proximal an outlet of the heat exchanger, at a low-side pressure proximal a pump inlet, and at a high-side pressure proximal a pump outlet. The MMS contains a controller communicably coupled to a valve between the tank and the heat exchanger outlet, a valve between the tank and the pump inlet, a valve between the tank and the pump outlet, and a valve between the tank and the offload terminal.
摘要翻译： 本发明的实施例通常提供热发动机系统，质量管理系统（MMS）以及用于在发电时调节热机系统中的压力的方法。 在一个实施例中，MMS包含在储存压力下流体耦合到泵，涡轮机，热交换器，卸载端子和容纳在罐中的工作流体的罐。 工作流体可以处于靠近热交换器的出口处的系统压力，在泵入口附近的低侧压力处，以及在泵出口附近的高侧压力。 MMS包含可控制地耦合到罐和热交换器出口之间的阀，罐和泵入口之间的阀，罐和泵出口之间的阀以及罐和卸载端之间的阀的控制器。
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公开(公告)号：US06261567B1
公开(公告)日：2001-07-17
申请号：US09082357
申请日：1998-05-20
IPC分类号： A61K3912
CPC分类号： A61K39/193 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/58 , C12N2760/16134 , C12N2770/24134 , C12N2770/36143
摘要： In this application is described a method for overcoming alphavirus vaccine interference in alphavirus-immune subjects by administration of a second alphavirus vaccine which is altered such that it is not accessible to interfering antibodies. Examples of such alterations are described as well as evidence showing that alphavirus interference likely results from the binding of interfering antibodies to viral proteins expressed on infected cells thereby causing lysis of infected cells.
摘要翻译： 在本申请中描述了通过施用第二种甲病毒疫苗来克服甲病毒 - 免疫受试者中的甲病毒疫苗干扰的方法，所述第二甲病毒疫苗被改变使得其不能被干扰抗体所接近。 描述了这种改变的实例以及证据表明甲病毒病毒干扰可能是由于干扰抗体与感染细胞上表达的病毒蛋白结合而引起的，从而导致感染细胞裂解。
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