公开(公告)号：US07695675B2

公开(公告)日：2010-04-13

申请号：US11079934

申请日：2005-03-14

申请人： Klaus Kaiser ,  Hans-Juergen Henzler ,  Joerg Kauling ,  Rolf Treckmann ,  Kathryn Remington ,  Cynthia J. Galloway

发明人： Klaus Kaiser ,  Hans-Juergen Henzler ,  Joerg Kauling ,  Rolf Treckmann ,  Kathryn Remington ,  Cynthia J. Galloway

IPC分类号： B08B17/00 ,  A61L2/00 ,  B01J19/08 ,  G01N23/00 ,  B01D63/00 ,  B01D21/26

CPC分类号： B01J19/123 ,  A23L3/28 ,  A61K41/0019 ,  A61L2/0005 ,  A61L2/0011 ,  A61L2/10 ,  A61M1/3681 ,  A61M1/3683 ,  A61M2205/053 ,  B01J19/2405 ,  B01J2219/00139 ,  B01J2219/00164 ,  B01J2219/00168 ,  C02F1/325 ,  C02F2201/32 ,  C02F2201/3223 ,  C02F2201/328 ,  Y10S422/905

摘要： A method of inactivating microorganisms such as viruses within a fluid such as a biological fluid is disclosed. The method includes the steps of providing a UV reactor, which may take the form of an elongated generally annular reaction chamber surrounding at least one elongated UV lamp, moving the fluid within the reaction chamber in a primary flow directed along the length of the UV lamp, and inducing a circulating secondary flow within the fluid with the secondary flow being superimposed on the primary flow. As the fluid moves through the reaction chamber in the primary flow, it is circulated repeatedly toward and away from the UV lamp in the circulating secondary flow to provide uniform and controllable exposure of the entire volume of fluid to ultraviolet radiation. Microorganisms such as viruses are thus inactivated while desirable components in the fluid, such as proteins, are preserved without the use of a free radical scavenger.

摘要翻译： 公开了一种灭活诸如生物流体之类的流体中的微生物如病毒的方法。 该方法包括以下步骤：提供UV反应器，UV反应器可采取围绕至少一个细长UV灯的细长的大致环形的反应室的形式，使反应室内的流体以沿着UV灯长度的一次流动 并且在所述流体中引起循环次级流，其中所述次流叠加在所述主流上。 当流体在初级流中移动通过反应室时，它在循环的二次流中反复地朝向和远离UV灯循环，以提供整个体积的流体对紫外线辐射的均匀和可控的曝光。 因此，微生物如病毒灭活，而流体中的期望组分（例如蛋白质）在不使用自由基清除剂的情况下被保存。

公开(公告)号：US20070003430A1

公开(公告)日：2007-01-04

申请号：US11079934

申请日：2005-03-14

申请人： Klaus Kaiser ,  Hans-Juergen Henzler ,  Joerg Kauling ,  Rolf Treckmann ,  Kathryn Remington ,  Cynthia Galloway

发明人： Klaus Kaiser ,  Hans-Juergen Henzler ,  Joerg Kauling ,  Rolf Treckmann ,  Kathryn Remington ,  Cynthia Galloway

IPC分类号： A61L2/10

CPC分类号： B01J19/123 ,  A23L3/28 ,  A61K41/0019 ,  A61L2/0005 ,  A61L2/0011 ,  A61L2/10 ,  A61M1/3681 ,  A61M1/3683 ,  A61M2205/053 ,  B01J19/2405 ,  B01J2219/00139 ,  B01J2219/00164 ,  B01J2219/00168 ,  C02F1/325 ,  C02F2201/32 ,  C02F2201/3223 ,  C02F2201/328 ,  Y10S422/905

摘要： A method of inactivating microorganisms such as viruses within a fluid such as a biological fluid is disclosed. The method includes the steps of providing a UV reactor, which may take the form of an elongated generally annular reaction chamber surrounding at least one elongated UV lamp, moving the fluid within the reaction chamber in a primary flow directed along the length of the UV lamp, and inducing a circulating secondary flow within the fluid with the secondary flow being superimposed on the primary flow. As the fluid moves through the reaction chamber in the primary flow, it is circulated repeatedly toward and away from the UV lamp in the circulating secondary flow to provide uniform and controllable exposure of the entire volume of fluid to ultraviolet radiation. Microorganisms such as viruses are thus inactivated while desirable components in the fluid, such as proteins, are preserved without the use of a free radical scavenger.

摘要翻译： 公开了一种灭活诸如生物流体之类的流体中的微生物如病毒的方法。 该方法包括以下步骤：提供UV反应器，UV反应器可采取围绕至少一个细长UV灯的细长的大致环形的反应室的形式，使反应室内的流体以沿着UV灯长度的一次流动 并且在所述流体中引起循环次级流，其中所述次流叠加在所述主流上。 当流体在初级流中移动通过反应室时，它在循环的二次流中反复地朝向和远离UV灯循环，以提供整个体积的流体对紫外线辐射的均匀和可控的曝光。 因此，微生物如病毒灭活，而流体中的期望组分（例如蛋白质）在不使用自由基清除剂的情况下被保存。