-
1.发明授权公开(公告)号：US07695675B2
公开(公告)日：2010-04-13
申请号：US11079934
申请日：2005-03-14
申请人： Klaus Kaiser , Hans-Juergen Henzler , Joerg Kauling , Rolf Treckmann , Kathryn Remington , Cynthia J. Galloway
发明人： Klaus Kaiser , Hans-Juergen Henzler , Joerg Kauling , Rolf Treckmann , Kathryn Remington , Cynthia J. Galloway
CPC分类号： B01J19/123 , A23L3/28 , A61K41/0019 , A61L2/0005 , A61L2/0011 , A61L2/10 , A61M1/3681 , A61M1/3683 , A61M2205/053 , B01J19/2405 , B01J2219/00139 , B01J2219/00164 , B01J2219/00168 , C02F1/325 , C02F2201/32 , C02F2201/3223 , C02F2201/328 , Y10S422/905
摘要： A method of inactivating microorganisms such as viruses within a fluid such as a biological fluid is disclosed. The method includes the steps of providing a UV reactor, which may take the form of an elongated generally annular reaction chamber surrounding at least one elongated UV lamp, moving the fluid within the reaction chamber in a primary flow directed along the length of the UV lamp, and inducing a circulating secondary flow within the fluid with the secondary flow being superimposed on the primary flow. As the fluid moves through the reaction chamber in the primary flow, it is circulated repeatedly toward and away from the UV lamp in the circulating secondary flow to provide uniform and controllable exposure of the entire volume of fluid to ultraviolet radiation. Microorganisms such as viruses are thus inactivated while desirable components in the fluid, such as proteins, are preserved without the use of a free radical scavenger.
摘要翻译： 公开了一种灭活诸如生物流体之类的流体中的微生物如病毒的方法。 该方法包括以下步骤：提供UV反应器，UV反应器可采取围绕至少一个细长UV灯的细长的大致环形的反应室的形式，使反应室内的流体以沿着UV灯长度的一次流动 并且在所述流体中引起循环次级流，其中所述次流叠加在所述主流上。 当流体在初级流中移动通过反应室时，它在循环的二次流中反复地朝向和远离UV灯循环，以提供整个体积的流体对紫外线辐射的均匀和可控的曝光。 因此，微生物如病毒灭活，而流体中的期望组分（例如蛋白质）在不使用自由基清除剂的情况下被保存。
-
公开(公告)号：US5658746A
公开(公告)日：1997-08-19
申请号：US552432
申请日：1995-11-03
IPC分类号： C12N15/09 , A61K47/48 , C12N15/02 , G01N33/554 , G01N33/566 , G01N33/68 , G01N33/567 , G01N33/53 , G01N33/531
CPC分类号： A61K47/48546 , A61K47/48369 , G01N33/554 , G01N33/566 , G01N33/6857 , G01N33/6863
摘要： A method of controlling the amount of a biologically active substance binding to a cell surface having both receptors to the substance and receptors for the Fc domain of an antibody that can complex with the substance or other antibodies that can complex with the substance. By exploiting the generally more numerous Fc receptor sites, substance binding can be increased and/or controlled. Method contemplates controlling amounts of substances such as cytokines, hormones, and growth factors that are associated with cells such as monocytes, macrophages, granulocytes, B cells, T cells, and platelets. Method is illustrated using conjugated antibodies to tissue necrosis factor (TNF) to increase the binding of TNF to monocytes.
摘要翻译： 控制与具有物质受体的细胞表面的结合的生物活性物质的量和与可与物质复合的物质或其它抗体复合的抗体Fc结构域的受体的量的方法。 通过利用通常更多的Fc受体位点，可以增加和/或控制物质结合。 方法考虑控制与诸如单核细胞，巨噬细胞，粒细胞，B细胞，T细胞和血小板等细胞相关的细胞因子，激素和生长因子的物质的量。 说明使用组织坏死因子（TNF）的结合抗体来增加TNF与单核细胞的结合的方法。
-
公开(公告)号：US5786458A
公开(公告)日：1998-07-28
申请号：US672255
申请日：1996-06-28
CPC分类号： A61L2/0023 , C07K1/22
摘要： A process for viral inactivation of a solution containing a biologically active protein, wherein the process comprises the steps of 1) contacting the solution with an immobilized ligand under conditions which allow protein to bind to the ligand, 2) subjecting the bound protein to a viral inactivation method under conditions which would result in substantial denaturation of the protein if it were not bound to the ligand, and 3) recovering the protein by washing the immobilized protein under conditions which favor the release of the protein into the solution under conditions in which the recovered protein retains its biological activity.
摘要翻译： 用于病毒灭活含有生物活性蛋白质的溶液的方法，其中所述方法包括以下步骤：1）使所述溶液与固定的配体在允许蛋白质结合所述配体的条件下接触，2）使结合的蛋白质与病毒 灭活方法，如果不结合配体会导致蛋白质的显着变性，以及3）在有利于将蛋白质释放到溶液中的条件下洗涤固定的蛋白质来回收蛋白质，其条件是 回收的蛋白质保留其生物活性。
-
-
搜索结果
3 条记录 (耗时 0.022 秒)