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公开(公告)号：US20090324702A1
公开(公告)日：2009-12-31
申请号：US12192927
申请日：2008-08-15
申请人： Shigeto Yoshida , Masanori Kawasaki , Makoto Matsumoto , Yoshio Ohba , Masahiro Saito , Yoshihiro Goto , Katsuya Inagaki , Masami Mizukoshi , Norimitsu Hariguchi , Kuniko Hirota
发明人： Shigeto Yoshida , Masanori Kawasaki , Makoto Matsumoto , Yoshio Ohba , Masahiro Saito , Yoshihiro Goto , Katsuya Inagaki , Masami Mizukoshi , Norimitsu Hariguchi , Kuniko Hirota
CPC分类号： A61K39/015 , A61K9/0043 , A61K9/007 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/394 , Y02A50/41 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza; and methods for preventing and treating infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient; and methods for preventing and treating infectious diseases such as malaria and influenza comprising administrating the recombinant baculovirus to patients.
摘要翻译： 本发明提供新型转移载体和重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物，其可用作传染病如疟疾和流感的预防或治疗药物; 以及预防和治疗疟疾和流感等传染病的方法。 更具体地，本发明提供能够表达在双重启动子控制下与病毒基因融合的外源基因的重组转移载体; 重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物; 以及用于预防和治疗诸如疟疾和流感的传染病的方法，包括向患者施用重组杆状病毒。
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公开(公告)号：US09333249B2
公开(公告)日：2016-05-10
申请号：US12192927
申请日：2008-08-15
申请人： Shigeto Yoshida , Masanori Kawasaki , Makoto Matsumoto , Yoshio Ohba , Masahiro Saito , Yoshihiro Goto , Katsuya Inagaki , Masami Mizukoshi , Norimitsu Hariguchi , Kuniko Hirota
发明人： Shigeto Yoshida , Masanori Kawasaki , Makoto Matsumoto , Yoshio Ohba , Masahiro Saito , Yoshihiro Goto , Katsuya Inagaki , Masami Mizukoshi , Norimitsu Hariguchi , Kuniko Hirota
IPC分类号： A61K39/145 , C12N15/00 , A61K35/76 , A61K9/127 , A61K39/015 , A61K39/04 , C07K14/005 , A61K39/12 , A61K9/00 , A61K39/00
CPC分类号： A61K39/015 , A61K9/0043 , A61K9/007 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/394 , Y02A50/41 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza; and methods for preventing and treating infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient; and methods for preventing and treating infectious diseases such as malaria and influenza comprising administrating the recombinant baculovirus to patients.
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公开(公告)号：US09327018B2
公开(公告)日：2016-05-03
申请号：US13617825
申请日：2012-09-14
申请人： Shigeto Yoshida , Masanori Kawasaki , Makoto Matsumoto , Yoshio Ohba , Masahiro Saito , Yoshihiro Goto , Katsuya Inagaki , Masami Mizukoshi , Norimitsu Hariguchi , Kuniko Hirota
发明人： Shigeto Yoshida , Masanori Kawasaki , Makoto Matsumoto , Yoshio Ohba , Masahiro Saito , Yoshihiro Goto , Katsuya Inagaki , Masami Mizukoshi , Norimitsu Hariguchi , Kuniko Hirota
IPC分类号： A61K39/12 , A61P33/06 , C12N7/01 , A61K39/015 , A61K39/04 , A61K39/145 , C07K14/005 , A61K9/00 , A61K39/00
CPC分类号： A61K39/015 , A61K9/0043 , A61K9/007 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/394 , Y02A50/41 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza; and methods for preventing and treating infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient; and methods for preventing and treating infectious diseases such as malaria and influenza comprising administrating the recombinant baculovirus to patients.
摘要翻译： 本发明提供新型转移载体和重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物，其可用作传染病如疟疾和流感的预防或治疗药物; 以及预防和治疗疟疾和流感等传染病的方法。 更具体地，本发明提供能够表达在双重启动子控制下与病毒基因融合的外源基因的重组转移载体; 重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物; 以及用于预防和治疗诸如疟疾和流感的传染病的方法，包括向患者施用重组杆状病毒。
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公开(公告)号：US20130022637A1
公开(公告)日：2013-01-24
申请号：US13617825
申请日：2012-09-14
申请人： Shigeto YOSHIDA , Masanori KAWASAKI , Makoto MATSUMOTO , Yoshio OHBA , Masahiro SAITO , Yoshihiro GOTO , Katsuya INAGAKI , Masami MIZUKOSHI , Norimitsu HARIGUCHI , Kuniko HIROTA
发明人： Shigeto YOSHIDA , Masanori KAWASAKI , Makoto MATSUMOTO , Yoshio OHBA , Masahiro SAITO , Yoshihiro GOTO , Katsuya INAGAKI , Masami MIZUKOSHI , Norimitsu HARIGUCHI , Kuniko HIROTA
CPC分类号： A61K39/015 , A61K9/0043 , A61K9/007 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/394 , Y02A50/41 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza; and methods for preventing and treating infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient; and methods for preventing and treating infectious diseases such as malaria and influenza comprising administrating the recombinant baculovirus to patients.
摘要翻译： 本发明提供新型转移载体和重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物，其可用作传染病如疟疾和流感的预防或治疗药物; 以及预防和治疗疟疾和流感等传染病的方法。 更具体地，本发明提供能够表达在双重启动子控制下与病毒基因融合的外源基因的重组转移载体; 重组杆状病毒; 生产方法; 含有重组杆状病毒作为活性成分的药物; 以及用于预防和治疗诸如疟疾和流感的传染病的方法，包括向患者施用重组杆状病毒。
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公开(公告)号：US20110201086A1
公开(公告)日：2011-08-18
申请号：US12705317
申请日：2010-02-12
CPC分类号： C12N15/86 , A61K39/015 , A61K2039/5256 , C12N7/00 , C12N2710/14043 , C12N2710/14143 , C12N2760/16134 , Y02A50/386 , Y02A50/394 , Y02A50/41 , Y02A50/412
摘要： To provide a method for producing, at high purity, a recombinant baculovirus which exhibits intended immunogenicity and is useful for a pharmaceutical (e.g., a vaccine), a transfer vector for use in the production of the recombinant baculovirus, and a method for producing the transfer vector. The method for producing a transfer vector which includes therein a fusion gene containing at least one gene encoding a virus-particle-forming protein and a gene encoding a foreign immunogenic protein, the method including modifying the polynucleotide sequence of the gene encoding the virus-particle-forming protein so as not to alter the amino acid residues constituting a corresponding naturally occurring virus-particle-forming protein and/or modifying the polynucleotide sequence of the gene so that a portion of the amino acid residues constituting the naturally occurring virus-particle-forming protein is deleted.
摘要翻译： 为了提供高纯度生产显示预期免疫原性并可用于药物（例如疫苗）的重组杆状病毒的方法，用于生产重组杆状病毒的转移载体，以及用于生产重组杆状病毒的方法 传输向量。 一种转移载体的制备方法，其中包含含有编码病毒颗粒形成蛋白质的至少一种基因和编码外源免疫原性蛋白质的基因的融合基因，所述方法包括修饰编码病毒颗粒的基因的多核苷酸序列 形成蛋白质，以便不改变构成相应的天然存在的病毒颗粒形成蛋白质的氨基酸残基和/或修饰该基因的多核苷酸序列，使得构成天然存在的病毒颗粒形成蛋白的部分氨基酸残基 形成蛋白质被删除。
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