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    ANTIBODY CAPABLE OF BINDING TO SPECIFIC REGION OF PERIOSTIN, AND METHOD FOR MEASURING PERIOSTIN USING SAME
    1.
    发明申请
    ANTIBODY CAPABLE OF BINDING TO SPECIFIC REGION OF PERIOSTIN, AND METHOD FOR MEASURING PERIOSTIN USING SAME 有权
    能够结合周期蛋白的特定区域的抗体以及使用其测量周期蛋白的方法

    公开(公告)号：US20140308685A1

    公开(公告)日：2014-10-16

    申请号：US14342996

    申请日：2012-09-06

    申请人： Kenji Izuhara ,  Shoichiro Ohta ,  Kazuhiko Arima ,  Hiroshi Shiraishi ,  Shoichi Suzuki ,  Tomoaki Hoshino ,  Yoshinori Azuma ,  Junya Ono

    发明人： Kenji Izuhara ,  Shoichiro Ohta ,  Kazuhiko Arima ,  Hiroshi Shiraishi ,  Shoichi Suzuki ,  Tomoaki Hoshino ,  Yoshinori Azuma ,  Junya Ono

    IPC分类号： G01N33/68 ,  C07K16/18

    CPC分类号： G01N33/6893 ,  C07K16/18 ,  C07K2317/14 ,  C07K2317/33 ,  G01N2333/47 ,  G01N2800/12

    摘要： The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin or a cleavage product thereof. The method and the reagent for measuring periostin and the method for improving accuracy in periostin measurement of the present invention is characterized by detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin. The method of testing for pulmonary fibrosis or interstitial pneumonia of the present invention includes the steps of a) measuring the amount or concentration of periostin in a sample derived from a subject, which measuring includes detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin and b) comparing the amount or concentration of the periostin in the sample derived from the subject with an amount or concentration of periostin in a sample derived from a living body not suffering from pulmonary fibrosis and interstitial pneumonia.

    摘要翻译： 本发明提供了一种精度更高的用于测定样品中的骨膜素的方法和试剂，提高骨膜素测定精度的方法以及以更高的精度测定肺纤维化或间质性肺炎的方法。 本发明的抗体与选自由EMI区域，R1区域，R2区域和骨膜素的R3区域或其切割产物组成的组中的至少一个区域结合。 用于测定骨膜素的方法和试剂以及本发明的骨膜素测定精度的提高方法的特征在于，检测从由EMI区域，R1区域，R2区域和R3组成的组中选择的至少一个区域 骨膜素的区域 本发明的肺纤维化或间质性肺炎的检测方法包括以下步骤：a）测量衍生自受试者的样品中骨膜素的量或浓度，所述测量包括检测至少一个选自以下的区域： EMI区域，R1区域，R2区域和骨膜素的R3区域，以及b）将源自受试者的样品中骨膜素的量或浓度与衍生自活体的样品中骨膜素的量或浓度进行比较 不患肺纤维化和间质性肺炎。

    Methods of testing for bronchial asthma or chronic obstructive pulmonary disease
    2.
    发明申请
    Methods of testing for bronchial asthma or chronic obstructive pulmonary disease 审中-公开
    支气管哮喘或慢性阻塞性肺疾病的检测方法

    公开(公告)号：US20050208496A1

    公开(公告)日：2005-09-22

    申请号：US10631467

    申请日：2003-07-31

    申请人： Noriko Ohtani ,  Yuji Sugita ,  Mutsuo Yamaya ,  Hiroshi Kubo ,  Hiroichi Nagai ,  Kenji Izuhara

    发明人： Noriko Ohtani ,  Yuji Sugita ,  Mutsuo Yamaya ,  Hiroshi Kubo ,  Hiroichi Nagai ,  Kenji Izuhara

    IPC分类号： A01K67/027 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P11/00 ,  A61P11/06 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/68 ,  G01N37/00

    CPC分类号： G01N33/6893 ,  C12Q1/6809 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2500/00 ,  G01N2800/122

    摘要： An objective of the present invention is to provide a method of testing for bronchial asthma or chronic obstructive pulmonary disease, a method of screening for candidate compounds for treating bronchial asthma or chronic obstructive pulmonary disease, and a pharmaceutical agent for treating bronchial asthma or chronic obstructive pulmonary disease. The present invention identified genes whose expression levels varied between respiratory epithelial cells that had been stimulated by IL-13 to induce the goblet cell differentiation, and unstimulated respiratory epithelial cells. The respiratory epithelial cells were cultured according to the air interface method. The genes were revealed to be useful as markers for testing for bronchial asthma or chronic obstructive pulmonary disease and screening for therapeutic agents for such diseases. Specifically, the present invention provides methods of testing for bronchial asthma or chronic obstructive pulmonary disease and methods of screening for compounds to treat the diseases based on the comparison of the expression levels of marker genes identified as described above.

    摘要翻译： 本发明的目的是提供支气管哮喘或慢性阻塞性肺疾病的检测方法，用于治疗支气管哮喘或慢性阻塞性肺疾病的候选化合物的筛选方法，以及用于治疗支气管哮喘或慢性阻塞性肺病的药剂 肺病。 本发明鉴定了由IL-13刺激的呼吸上皮细胞诱导杯状细胞分化的表达水平变化的基因和未刺激的呼吸上皮细胞。 根据空气界面方法培养呼吸道上皮细胞。 这些基因被揭示为可用作测试支气管哮喘或慢性阻塞性肺疾病和筛选这些疾病的治疗剂的标记物。 具体地，本发明提供了用于支气管哮喘或慢性阻塞性肺疾病的检测方法以及基于如上所述鉴定的标记基因的表达水平的比较来筛选化合物治疗疾病的方法。

    Antibody capable of binding to specific region of periostin, and method of measuring periostin using the same
    5.
    发明授权
    Antibody capable of binding to specific region of periostin, and method of measuring periostin using the same 有权
    能够结合骨膜素的特定区域的抗体以及使用其的骨膜素测定方法

    公开(公告)号：US09347954B2

    公开(公告)日：2016-05-24

    申请号：US14342996

    申请日：2012-09-06

    申请人： Kenji Izuhara ,  Shoichiro Ohta ,  Kazuhiko Arima ,  Hiroshi Shiraishi ,  Shoichi Suzuki ,  Tomoaki Hoshino ,  Yoshinori Azuma ,  Junya Ono

    发明人： Kenji Izuhara ,  Shoichiro Ohta ,  Kazuhiko Arima ,  Hiroshi Shiraishi ,  Shoichi Suzuki ,  Tomoaki Hoshino ,  Yoshinori Azuma ,  Junya Ono

    IPC分类号： C07K16/18 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  C07K16/18 ,  C07K2317/14 ,  C07K2317/33 ,  G01N2333/47 ,  G01N2800/12

    摘要： The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin or a cleavage product thereof. The method and the reagent for measuring periostin and the method for improving accuracy in periostin measurement of the present invention is characterized by detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin. The method of testing for pulmonary fibrosis or interstitial pneumonia of the present invention includes the steps of a) measuring the amount or concentration of periostin in a sample derived from a subject, which measuring includes detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin and b) comparing the amount or concentration of the periostin in the sample derived from the subject with an amount or concentration of periostin in a sample derived from a living body not suffering from pulmonary fibrosis and interstitial pneumonia.

    摘要翻译： 本发明提供了一种精度更高的用于测定样品中的骨膜素的方法和试剂，提高骨膜素测定精度的方法以及以更高的精度测定肺纤维化或间质性肺炎的方法。 本发明的抗体与选自由EMI区域，R1区域，R2区域和骨膜素的R3区域或其切割产物组成的组中的至少一个区域结合。 用于测定骨膜素的方法和试剂以及本发明的骨膜素测定精度的提高方法的特征在于，检测从由EMI区域，R1区域，R2区域和R3组成的组中选择的至少一个区域 骨膜素的区域 本发明的肺纤维化或间质性肺炎的检测方法包括以下步骤：a）测量衍生自受试者的样品中骨膜素的量或浓度，所述测量包括检测至少一个选自以下的区域： EMI区域，R1区域，R2区域和骨膜素的R3区域，以及b）将源自受试者的样品中骨膜素的量或浓度与衍生自活体的样品中骨膜素的量或浓度进行比较 不患肺纤维化和间质性肺炎。