公开(公告)号：US09376438B2

公开(公告)日：2016-06-28

申请号：US14117927

申请日：2012-05-16

申请人： David Michael Goldstein ,  Kenneth Albert Brameld

发明人： David Michael Goldstein ,  Kenneth Albert Brameld

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P29/00 ,  A61P19/02 ,  A61P11/06 ,  A61P17/06

CPC分类号： C07D487/04

摘要： The present disclosure provides compounds of Formula (I)and pharmaceutically acceptable salts that are tyrosine kinase inhibitors,in particular BLK, BMX, EGFR, HER2, HER4, ITK, Jak3, TEC, Btk, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts and processes for preparing such compounds and pharmaceutically acceptable salts.

摘要翻译： 本公开提供式（I）化合物和其药学上可接受的盐，其是酪氨酸激酶抑制剂，特别是BLK，BMX，EGFR，HER2，HER4，ITK，Jak3，TEC，Btk和TXK，因此可用于治疗 通过抑制酪氨酸激酶如癌症和炎性疾病如关节炎等可治疗的疾病。 还提供了含有这些化合物的药物组合物和药学上可接受的盐以及制备这些化合物和药学上可接受的盐的方法。

公开(公告)号：USD246292S

公开(公告)日：1977-11-08

申请号：US605366

申请日：1975-08-15

申请人： Kenneth Albert Jordan

设计人： Kenneth Albert Jordan

公开(公告)号：US4024734A

公开(公告)日：1977-05-24

申请号：US605368

申请日：1975-08-15

申请人： Kenneth Albert Jordan

发明人： Kenneth Albert Jordan

IPC分类号： D04B35/14 ,  B65H63/028 ,  B65H63/06 ,  D03D51/24 ,  B65H63/02 ,  D04B35/18

CPC分类号： B65H63/028 ,  B65H2701/31

摘要： A yarn fault detector suitable for mounting on a main frame of a knitting machine or on a side creel. The detector has two yarn guides on a guide frame that is biased to an operative yarn guiding position but movable overcenter to a yarn releasing position. End portions of a freely pivotable stop bar contact the yarn guides in the operative position of the guide frame to assure adequate contact with both guides. A variable bias is applied to the guide frame by means of a loop of flexible material on a rotary shaft, and a spring under tension between the loop and an eccentric cranked portion of the guide frame, the tension being dependent on the length of the loop wrapped around the shaft by rotation of the shaft. The loop and shaft are made by a one-piece moulding operation.The invention relates to yarn fault detectors, sometimes known as "top detectors," for detecting breaks and excessive tensions in yarns supplied to textile machinery such as knitting machines, from creels mounted at the top of such machines. Such detectors include lightweight pivotally mounted detector wires which rest on a yarn passing over a pair of guides and which, when the yarn breaks, fall to complete an electrical circuit for actuating a stop motion relay to stop the machine. Excessive tensions in the yarn wound on the creel are detected by pivotally mounting the guides and urging them to an operative yarn guiding position by means of an overcentre device. The top detector in use is positioned so that any tension in the yarn passing from the creel and over the guides to the machine tends to urge the guides to move overcentre to a yarn releasing position, in which case the detector wire falls to complete the circuit for the stopmotion relay as above. The guides are generally provided with ceramic guiding surfaces on a wire frame, and the bias urging the guides overcentre to the operative yarn guiding position is preferably variable.One problem that has been experienced when using such detectors is that when there is rapid decrease in the rate of demand for yarn by the machine, the yarn passing from the creel to the top detector tends to overshoot the guides and the resulting slackening of the yarn can cause the yarn to become wrapped around the guide nearer the creel rather than passing smoothly over it. It has been proposed to avoid this occurrence by causing the guide nearer the creel to contact a lug on the frame of the top detector, so that there is no space between the guide and lug to permit the yarn to depart from its intended path. The provision of one such lug is perfectly satisfactory when the top detector is designed solely for mounting on the frame of the machine. It is however desirable for the top detectors to be mountable optionally on side creels or on the frame of the machine, using the same snap-on fitment at one side of the top detector for both mountings. When the top detectors are designed in this way it is found that the direction of yarn travel is reversed when the detector is turned round and mounted on a side creel, relative to that when it is mounted on the frame of the machine. Thus the lug referred to above is no longer associated with the guide nearer the creel, and it is necessary to provide an additional lug for cooperation with the other of the guides. The disadvantage of such a construction is that it is very rare for the guides both firmly to contact their associated lugs at all times. What in fact happens is that the frame mounting the guides is not quite in alignment with the plane of the lugs, so that only one of the guides is in contact with its associated lug. This tendency is much more pronounced when the tension biasing the guides upwardly to their operative positions is very light. If only the guide remote from the creel is firmly in contact with its associated lug, the yarn can become wrapped around the above guide in precisely the manner indicated above.Another problem associated with such fault detectors is the difficulty of producing a variable bias on the guide frames. In the past the coil springs in such fault detectors have been tensioned by engaging one end of the spring in a U-loop of filament the free ends of which are entrapped in the central split of a cotter pin. A knob is mounted on an end of the cotter pin by means of a grub screw, and turning of the knob causes the filament to wrap around the cotter pin, thus shortening the length of filament between the cotter pin and spring and extending the spring so as to increase its tension. There are problems in assembling and using such a device. Assembly is difficult as the free ends of the U-loop of filament have to be inserted in the split of the cotter pin. Generally this is made easier by first heat-welding the free ends to one another, but this in itself is a time-consuming operation. When assembled, the device has to be set to provide an appropriate minimum or maximum tension to the spring so as to provide meaning to calibrations on the knob. This is achieved by gripping the bent-over end of the cotter pin with pliers and turning the pin until the desired reference (maximum or minimum) tension is obtained, and then tightening the grub screw to fix the knob on the opposite end of the cotter pin with the knob in the desired angular condition. This too is a time-consuming operation.OBJECTS OF THE INVENTIONIt is an object of the present invention to provide a top detector which avoids the above problems of entanglement of the yarn in the yarn guides.It is a further object of the present invention to provide a top detector of simple and economical construction in which the bias on the guide frame can be easily adjusted.It is a further object of the present invention to provide a top detector in which the calibration of the bias on the guide frame can be re-zeroed in a simple and rapid manner.Other objects will become apparent from the following description.SUMMARY OF THE INVENTIONThe invention provides a yarn fault detector for textile machinery, comprisinga housing,detector wire means pivotally mounted on said housing,a pivotable guide frame pivotally mounted on said housing and movable overcentre between an operative yarn guiding position and a yarn releasing position,means within said housing biasing said guide frame to its yarn guiding or releasing positions,a pair of yarn guides on said guide frame,a fixed guard frame having side guards, one at each side of said pair of yarn guides, extending from said guide frame for further guiding yarn through the detector and,a freely pivotable stop bar on said fixed guard frame for contacting both of said yarn guides when said guide frame is in its operative position.Because the yarn guides contact a freely pivotable stop bar rather than fixed lugs, there is always good contact between the guides and the stop bar sufficient to prevent the yarn from passing therebetween, irrespective of the direction of passage of the yarn. When the pivotal axis of the stop bar is midway between the yarn guides, the force opposing the bias urging the guide frame to its operative position is shared equally between the two guides.The guides are preferably ceramic guides on a wire pivotable guide frame. The stop bar may be mounted by any desired means, such as by a pivot pin or by having its ends freely slidable in slots in a frame of the top detector and its mid portion engageable with a fulcrum when the guide frame biases the stop bar thereagainst. The stop bar may be of any desired cross-section.The invention also provides a yarn fault detector for textile machinery, comprisinga housing,detector wire means pivotally mounted on said housing,a pivotable guide frame pivotally mounted on said housing and movable overcentre between an operative yarn guiding position and a yarn releasing position,a one-piece moulding of a resilient plastics material having an integral loop portion and a shaft portion and being rotatably mounted within said housing,a control knob externally of said housing, associated with said one-piece moulding for effecting rotation thereof,a cranked portion of said guide frame internally of said housing, andresilient means between said cranked guide frame portion and said loop portion for biasing said guide frame towards its yarn guiding and releasing conditions with a bias that is dependent on the amount of said loop portion that is wrapped around said shaft portion. In use, the guide frame is biased to its operative position with a bias that may be varied by rotating the rotary shaft to wrap more or less of the flexible loop thereon. The loop portion is advantageously pre-stretched to reduce its tendency to creep. The rotary shaft may be rotatable by means of a knob splined to the shaft and removable axially, so that the knob can be removed axially, turned to any desired angular orientation and pushed back onto or into the shaft. This facilitates rapid setting of the knob to a given reference position of maximum or minimum tension.Preferably the rotary shaft is made from a resilient plastics material such as nylon and also comprises an integral serrated disc the serrations of which are adapted in use to ride over a projection, such as a ridge or dimple, to give a resistance to turning.

摘要翻译： 一种适用于安装在针织机的主框架或侧架架上的纱线故障检测器。 检测器在引导框架上具有两个导纱器，该引导框架被偏压到可操作的纱线引导位置，但可移动的越过中心到纱线释放位置。 可自由枢转的止动杆的端部在引导框架的操作位置接触导纱器，以确保与两个引导件的充分接触。 通过旋转轴上的柔性材料环和引导框架的偏心曲柄部分之间的张力下的弹簧将可变偏压施加到引导框架，张力取决于环的长度 通过轴的旋转缠绕在轴上。 环和轴通过一体式成型操作制成。

公开(公告)号：US3977665A

公开(公告)日：1976-08-31

申请号：US489443

申请日：1974-07-17

申请人： Kenneth Albert Bowman ,  Royston Gilbert Breddy ,  Royston John West

发明人： Kenneth Albert Bowman ,  Royston Gilbert Breddy ,  Royston John West

IPC分类号： B42C19/06 ,  B41F13/58

CPC分类号： B42C19/06

摘要： An in-line book making system produces sets of signatures ready for "come and go" binding. Webs printing in respective presses are slit collated and folded into signatures which are fed in succession to two collecting pockets, one pocket receiving a batch of signatures totalling all the pages of the book and then the other pocket receiving a similar batch. The batches are fed in identical orientations from the respective pockets to respective conveyors, which cause a relative rotation of the batches through 180.degree.. The two batches are then brought together, when they together contain all the pages for two books in a disposition which can be bound in come and go binding and then cut apart.The signatures may be made by a former-folding process.The conveyor system may additionally be operable to eliminate the 180.degree. relative rotation, in case simple binding is desired.

摘要翻译： 一个在线书籍制作系统生成了一套准备好“走出去”的签名。 在相应的印刷机中印刷的网印被对照并折叠成签名，这些签名被连续馈送到两个收集袋，一个口袋接收一批总数为书的所有页面的签名，然后另一个口袋接收相似的批次。 批料以相同的方向从相应的袋输送到相应的输送机，这导致批料相对旋转180°。 然后把这两个批次放在一起，当它们一起包含两本书的所有页面，这些书籍可以捆绑在一起，然后分开。

公开(公告)号：US20140221398A1

公开(公告)日：2014-08-07

申请号：US14117927

申请日：2012-05-16

申请人： David Michael Goldstein ,  Kenneth Albert Brameld

发明人： David Michael Goldstein ,  Kenneth Albert Brameld

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The present disclosure provides compounds and pharmaceutically acceptable salts that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, Jak3, TEC, Btk, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts and processes for preparing such compounds and pharmaceutically acceptable salts.

摘要翻译： 本公开提供了酪氨酸激酶抑制剂，特别是BLK，BMX，EGFR，HER2，HER4，ITK，Jak3，TEC，Btk和TXK的化合物和药学上可接受的盐，因此可用于治疗可通过抑制 酪氨酸激酶如癌症和炎性疾病如关节炎等。 还提供了含有这些化合物的药物组合物和药学上可接受的盐以及制备这些化合物和药学上可接受的盐的方法。

公开(公告)号：US20130226933A1

公开(公告)日：2013-08-29

申请号：US13404157

申请日：2012-02-24

申请人： David Kenneth ALBERT

发明人： David Kenneth ALBERT

IPC分类号： G06F17/30

CPC分类号： G06F17/30867 ,  G06F17/3053 ,  G06Q10/063 ,  G06Q10/0633

摘要： A system and method for determining a newsworthiness score for a news story, including the steps of receiving data describing a news story from a client, comparing the data describing the news story to a set of pre-determined factors, locating the factors that are present on the set of pre-determined factors in the data, adding pre-calculated values to a running total, the newsworthiness score, for each factor found in the data.

摘要翻译： 一种用于确定新闻故事的新闻可靠度得分的系统和方法，包括从客户接收描述新闻故事的数据的步骤，将描述新闻故事的数据与一组预先确定的因素进行比较，找出存在的因素 对数据中的一组预先确定的因素，将数据中的每个因素的预计值添加到运行总计的新闻可靠性分数。

公开(公告)号：US20060153914A1

公开(公告)日：2006-07-13

申请号：US11370842

申请日：2006-03-09

申请人： Kenneth Albert ,  Paul Maes

发明人： Kenneth Albert ,  Paul Maes

IPC分类号： A61K31/553 ,  A61K9/22

CPC分类号： A61K9/5078 ,  A61K9/2081 ,  A61K31/553

摘要： A controlled-release Galenical preparation of pharmaceutically acceptable Diltiazem including the pharmaceutically acceptable salts thereof, suitable for evening dosing every 24 hours containing from about 120 mg to about 540 mg or more (as desired) of the form of Diltiazem associated with excipients to provide controlled (sustained) release of the form of Diltiazem for providing a Cmax of Diltiazem in the blood at between about 10 hours and about 15 hours after administration, the preparation comprising the form of Diltiazem in oral sustained-release dosage form in which the Diltiazem is adapted to be released after administration over a prolonged period of time and exhibits when given to humans (i) a higher bioavailability when given at night compared to when given in the morning without food according to FDA guidelines or criteria and (ii) bioequivalence when given in the morning with and without food according to the same FDA guidelines or criteria.

摘要翻译： 药物可接受的地尔硫卓的控释制剂，包括其药学上可接受的盐，适合每24小时晚间给药，含有约120mg至约540mg或更多（如所需）与赋形剂相关的地尔硫卓形式，以提供受控制 （持续）释放形式的地尔硫卓，在给药后约10小时至约15小时之间，在血液中提供地塞米松的最大值，该制剂包含口服持续释放的地尔硫卓形式 剂量形式，其中地尔硫卓适于在长时间施用后释放，并在给予人时显示（i）在晚上给予时比在早晨没有食物时根据FDA指南或标准给予更高的生物利用度 和（ii）根据相同的FDA指导方针或标准，早晨给予和不含食物时，生物等效性。

公开(公告)号：US4033542A

公开(公告)日：1977-07-05

申请号：US713518

申请日：1976-08-11

申请人： Kenneth Albert Moehle ,  Raymond George Taschner

发明人： Kenneth Albert Moehle ,  Raymond George Taschner

IPC分类号： B60G99/00 ,  B62D33/06

CPC分类号： B60G99/002 ,  B62D33/0604

摘要： A dual spring support for particular use in supporting a vehicle or tractor cab or the like, and specifically including two co-axially disposed springs extending intermediate two spaced-apart vehicle members which are to be cushion supported relative to each other. An abutment piece is disposed between two ends of the two springs, and abutment surfaces are disposed at the other two ends of the two springs, all so that the springs are opposing in their forces and increase the force at each end of the stroke. Also a shock absorber is shown incorporated in the assembled support.

摘要翻译： 一种双弹簧支架，用于特别用于支撑车辆或拖拉机驾驶室等，并且具体地包括两个同轴设置的弹簧，两个相互相邻的两个间隔开的车辆构件将被缓冲支撑。 邻接件设置在两个弹簧的两个端部之间，并且邻接表面设置在两个弹簧的另外两个端部处，所有这些弹簧都以它们的力相对并增加了在行程的每一端的力。 还示出了组装的支撑件中的减震器。

公开(公告)号：US06747090B2

公开(公告)日：2004-06-08

申请号：US10196445

申请日：2002-07-16

申请人： Jacqueline Hermina De Groot ,  Kenneth Albert Hodd ,  Hendrik Jan Haitjema

发明人： Jacqueline Hermina De Groot ,  Kenneth Albert Hodd ,  Hendrik Jan Haitjema

IPC分类号： C08F2006

CPC分类号： C08L53/00 ,  A61L27/52 ,  C08F8/10 ,  C08F8/12 ,  C08F8/40 ,  C08F263/04 ,  C08F271/02 ,  C08F290/04 ,  C08F2810/50 ,  C08L51/003 ,  Y10S522/904 ,  C08F226/10

摘要： The invention related to a hydrogel forming aqueous composition of water soluble polymers having a sufficiently high coherency that it substantially not is dispersed when being injected into an aqueous environment of a body site such as the capsular bag of the eye to undergo a photoinitiated crosslinking reaction. The water soluble polymers either can be a water-soluble polymer bearing free acrylic, or other vinylic groups capable of facile free radical reaction with a polymeric water-soluble photoinitiator also present in the composition, or a water-soluble polymer bearing both free acrylic, or other vinylic groups capable of facile free radical reaction and photoinitiator, wherein both polymers are capable of being crosslinked when irradiated with light of wavelengths greater than about 305 nm to form the hydrogel.

摘要翻译： 本发明涉及具有足够高相关性的水溶性聚合物的水凝胶形成用水性组合物，当将其注入体内部位的水性环境（例如眼睛囊袋）进行光引发的交联反应时，其基本上不分散。 水溶性聚合物可以是具有游离丙烯酸酯或能够与也存在于组合物中的聚合物水溶性光引发剂易于自由基反应的其它乙烯基的水溶性聚合物，或者是含有游离丙烯酸， 或能够容易地自由基反应的其它乙烯基团和光引发剂，其中两种聚合物当用波长大于约305nm的光照射时能够交联以形成水凝胶。

公开(公告)号：US06613343B2

公开(公告)日：2003-09-02

申请号：US09834212

申请日：2001-04-12

申请人： Keith Alfred Dillingham ,  Hendrik Deuring ,  Jöns Gunnar Hilborn ,  László Garamszegi ,  Kenneth Albert Hodd ,  Hendrik Jan Haitjema

发明人： Keith Alfred Dillingham ,  Hendrik Deuring ,  Jöns Gunnar Hilborn ,  László Garamszegi ,  Kenneth Albert Hodd ,  Hendrik Jan Haitjema

IPC分类号： A61F216

CPC分类号： C08L83/08 ,  A61L27/18 ,  A61L2400/06 ,  A61L2430/16 ,  G02B1/043 ,  C08L83/04

摘要： The present invention relates to compositions comprising polysiloxanes suitable for the preparation of accommodating intraocular lenses, having a specific gravity of greater than about 1.0, a refractive index suitable for restoring the refractive power of the natural crystalline lens and a viscosity suitable for injection through a standard cannula. The present invention includes intraocular lenses made from said polysiloxane compositions having a Young's modulus less than about 10 kPa.