公开(公告)号：US20160009816A1

公开(公告)日：2016-01-14

申请号：US14693261

申请日：2015-04-22

Applicant: Gerd Ritter ,  Beatrice Yin ,  Anne Murray ,  George Mark ,  Lloyd J. Old ,  Kenneth Lloyd ,  Serhiy Souchelnytskiy ,  Ivan Gout ,  Valeriy Filonenko ,  Ramziya Kiyamova

Inventor： Gerd Ritter ,  Beatrice Yin ,  Anne Murray ,  George Mark ,  Lloyd J. Old ,  Kenneth Lloyd ,  Serhiy Souchelnytskiy ,  Ivan Gout ,  Valeriy Filonenko ,  Ramziya Kiyamova

IPC: C07K16/30 ,  A61K39/00 ,  G01N33/574 ,  C07K14/705

CPC classification number: C07K16/3069 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/53 ,  C07K7/08 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  G01N33/57449 ,  G01N2333/705 ,  G01N2500/04

Abstract: The present invention relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The SLC34A2 epitope peptide encompassing amino acids 312-340 of SLC34A2 has been identified as an ovarian cancer epitope using the monoclonal antibody MX35. The invention also relates to the use of SLC34A2 and particularly SLC34A2 peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against NaPi2b (SLC34A2) and the SLC34A2 peptide(s), including veneered, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treatment of tumors and cancer are also provided. Assays for screening and identifying compounds directed against SLC34A2, including the SLC34A2 epitope peptide, and additional antibodies are provided.

Abstract translation: 本发明一般涉及作为治疗靶标的膜转运体NaPi2b（SLC34A2），包括免疫治疗，特别是癌症治疗。 包含SLC34A2的氨基酸312-340的SLC34A2表位肽已经使用单克隆抗体MX35鉴定为卵巢癌表位。 本发明还涉及SLC34A2和特别是SLC34A2肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。 本发明进一步涉及特异性针对NaPi2b（SLC34A2）和SLC34A2肽的抗体，包括贴面，嵌合，单链和人源化抗体。 还提供了产生免疫应答和治疗肿瘤和癌症的方法。 提供筛选和鉴定针对SLC34A2的化合物，包括SLC34A2表位肽和其他抗体的测定。

公开(公告)号：US08603474B2

公开(公告)日：2013-12-10

申请号：US12735576

申请日：2009-01-29

Applicant: Gerd Ritter ,  Beatrice Yin ,  Anne Murray ,  George Mark ,  Lloyd Old ,  Kenneth Lloyd ,  Serhiy Souchelnytskiy ,  Ivan Gout ,  Valeriy Filonenko ,  Ramziya Kiyamova

Inventor： Gerd Ritter ,  Beatrice Yin ,  Anne Murray ,  George Mark ,  Lloyd Old ,  Kenneth Lloyd ,  Serhiy Souchelnytskiy ,  Ivan Gout ,  Valeriy Filonenko ,  Ramziya Kiyamova

IPC: A61K39/395 ,  G01N33/53 ,  C07K16/00 ,  C07K16/28 ,  C07K16/18

CPC classification number: C07K16/3069 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/53 ,  C07K7/08 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  G01N33/57449 ,  G01N2333/705 ,  G01N2500/04

Abstract: The present disclosure relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The SLC34A2 epitope peptide encompassing amino acids 312-340 of SLC34A2 has been identified as an ovarian cancer epitope using the monoclonal antibody MX35. The invention also relates to the use of SLC34A2 and particularly SLC34A2 peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against NaPi2b (SLC34A2) and the SLC34A2 peptide(s), including veneered, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treatment of tumors and cancer are also provided. Assays for screening and identifying compounds directed against SLC34A2, including the SLC34A2 epitope peptide, and additional antibodies are provided.

Abstract translation: 本公开总体上涉及作为治疗靶标的膜转运体NaPi2b（SLC34A2），包括免疫治疗，特别是癌症治疗。 包含SLC34A2的氨基酸312-340的SLC34A2表位肽已经使用单克隆抗体MX35鉴定为卵巢癌表位。 本发明还涉及SLC34A2和特别是SLC34A2肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。 本发明进一步涉及特异性针对NaPi2b（SLC34A2）和SLC34A2肽的抗体，包括贴面，嵌合，单链和人源化抗体。 还提供了产生免疫应答和治疗肿瘤和癌症的方法。 提供筛选和鉴定针对SLC34A2的化合物，包括SLC34A2表位肽和其他抗体的测定。

公开(公告)号：US20120256061A1

公开(公告)日：2012-10-11

申请号：US13426847

申请日：2012-03-22

Applicant: Kenneth Lloyd Wainionpaa

Inventor： Kenneth Lloyd Wainionpaa

IPC: A47F7/00

CPC classification number: G09B23/36

Abstract: Scale model fish and wildlife replicas are mounted on rectangular shaped bases and can be displayed individually, attached to one another by using a dog-bone clip or pin, or slid into a vertical, or wall mounted base unit capable of holding 5, 10, or more replicas. The top and bottom edges of the replica mounting base and the inside edges of the slots on the wall mount base, are angled to allow the user to slid the mounted replica into the base unit easily, resulting in a secure mount. The replica mounting bases and the wall-mounted bases will be made of wood, and/or various plastics or resins using current processes. The back side of the replica mounting bases have slots to attach the dog-bone clips, and a slot to hang on a nail, or other device.

Abstract translation: 鱼鳞鱼和野生动物复制品安装在矩形基座上，可以单独显示，通过使用狗骨夹或销彼此相连，或滑入垂直或壁挂式基座，能够容纳5,10， 或更多的副本。 复制安装底座的顶部和底部边缘以及墙壁安装基座上的槽的内部边缘是成角度的，以允许使用者容易地将安装的复制品滑入基座单元，从而形成安全的安装。 复制安装基座和壁挂式基座将由木材和/或使用当前工艺的各种塑料或树脂制成。 复制安装基座的背面具有用于附接狗骨夹的槽，以及用于挂在钉子上的槽或其它装置。

公开(公告)号：US08228510B2

公开(公告)日：2012-07-24

申请号：US13324149

申请日：2011-12-13

Applicant: John Gregory Pangrazio ,  John Alan Pangrazio ,  Robert Thomas Pangrazio ,  Kenneth Lloyd Brey ,  Cesar Pena-Gutierrez

Inventor： John Gregory Pangrazio ,  John Alan Pangrazio ,  Robert Thomas Pangrazio ,  Kenneth Lloyd Brey ,  Cesar Pena-Gutierrez

IPC: G01B11/14 ,  G01B11/00 ,  G06K9/00

CPC classification number: G01B11/00 ,  B66F9/0755 ,  B66F17/003

Abstract: An improved dimensional detection system is portable and can be used to characterize a workpiece. The dimensional detection system employs as few as a single focused light source and as few as a single camera along with a calibration data set to convert the illuminated pixels of an image of a beam on the workpiece into a cloud of real world points in space on an outer surface of the workpiece. The cloud of points can be processed to characterize the workpiece, such as by determining the right hexahedron that would encompass all of the real world points in space and which could be used to determine a dimensional weight of the workpiece.

Abstract translation: 改进的尺寸检测系统是便携式的并且可以用于表征工件。 尺寸检测系统仅使用单个聚焦光源和少量单个照相机以及校准数据集，将工件上的光束的图像的照明像素转换为空间中的真实世界点的云 工件的外表面。 可以处理点的云以表征工件，例如通过确定正确的六面体将包含空间中的所有真实世界点并且可以用于确定工件的尺寸权重。

公开(公告)号：US20110286007A1

公开(公告)日：2011-11-24

申请号：US12784622

申请日：2010-05-21

Applicant: John Gregory Pangrazio ,  John Alan Pangrazio ,  Robert Thomas Pangrazio ,  Kenneth Lloyd Brey ,  Cesar Pena-Gutierrez

Inventor： John Gregory Pangrazio ,  John Alan Pangrazio ,  Robert Thomas Pangrazio ,  Kenneth Lloyd Brey ,  Cesar Pena-Gutierrez

IPC: G01B11/14 ,  G01B11/00

CPC classification number: G01B11/00 ,  B66F9/0755 ,  B66F17/003

Abstract: An improved dimensional detection system is portable and can be used to characterize a workpiece. The dimensional detection system employs as few as a single focused light source and as few as a single camera along with a calibration data set to convert the illuminated pixels of an image of a beam on the workpiece into a cloud of real world points in space on an outer surface of the workpiece. The cloud of points can be processed to characterize the workpiece, such as by determining the right hexahedron that would encompass all of the real world points in space and which could be used to determine a dimensional weight of the workpiece.

Abstract translation: 改进的尺寸检测系统是便携式的并且可以用于表征工件。 尺寸检测系统仅使用单个聚焦光源和少量单个照相机以及校准数据集，将工件上的光束的图像的照明像素转换为空间中的真实世界点的云 工件的外表面。 可以处理点的云以表征工件，例如通过确定正确的六面体将包含空间中的所有真实世界点并且可以用于确定工件的尺寸权重。

公开(公告)号：US07513989B1

公开(公告)日：2009-04-07

申请号：US09869990

申请日：2000-01-14

Applicant: Stuart Leon Soled ,  Kenneth Lloyd Riley ,  Gary P. Schleicher ,  Richard A. Demmin ,  Darlene Schuette, legal representative ,  Ian Alfred Cody

Inventor： William L. Schuette

IPC: C10G47/04

CPC classification number: C08F8/00 ,  B01J23/002 ,  B01J23/8885 ,  B01J35/1019 ,  B01J35/1038 ,  B01J37/03 ,  B01J37/04 ,  B01J37/20 ,  B01J2523/00 ,  C08F8/04 ,  C08F8/50 ,  C10G45/08 ,  C10G45/16 ,  C10G47/04 ,  C10G65/04 ,  C10G65/08 ,  C10G65/12 ,  C10G2400/10 ,  C10G2400/14 ,  C08F240/00 ,  B01J2523/68 ,  B01J2523/69 ,  B01J2523/847

Abstract: The invention relates to a hydrocracking process for hydrocracking petroleum and chemical feedstocks using bulk Group VIII/VIB catalysts. Preferred catalysts include those comprised of Ni—Mo—W.

Abstract translation: 本发明涉及使用本体VIII / VIB催化剂加氢裂化石油和化学原料的加氢裂化方法。 优选的催化剂包括由Ni-Mo-W组成的催化剂。

公开(公告)号：US20090007095A1

公开(公告)日：2009-01-01

申请号：US11768256

申请日：2007-06-26

Applicant: Kenneth Lloyd Alverson ,  Nirav Kamdar ,  Steven Richie Wood ,  Cezar Ungureanasu

Inventor： Kenneth Lloyd Alverson ,  Nirav Kamdar ,  Steven Richie Wood ,  Cezar Ungureanasu

IPC: G06F9/445

CPC classification number: G06F8/61

Abstract: Systems and methods that facilitate deployment of server applications via employing a deployment system that declaratively defines deployment actions. Such system is extensible to enable user customization, and includes a deployment document that declaratively defines deployment terms. The deployment document can further describe what the tasks accomplish, and also what tasks are to be forwarded to the task handler at execution time.

Abstract translation: 通过采用声明性地定义部署操作的部署系统来促进部署服务器应用程序的系统和方法。 这种系统是可扩展的，以允许用户定制，并且包括声明性地定义部署术语的部署文档。 部署文档可以进一步描述任务的完成情况，以及在执行时将什么任务转发到任务处理程序。

公开(公告)号：US20080221122A1

公开(公告)日：2008-09-11

申请号：US11934677

申请日：2007-11-02

Applicant: Michael A. Palladino ,  George Kenneth Lloyd ,  Yoshio Hayashi

Inventor： Michael A. Palladino ,  George Kenneth Lloyd ,  Yoshio Hayashi

IPC: A61K31/496 ,  C07D403/06 ,  A61P35/02 ,  A61P35/00 ,  C07D413/06

CPC classification number: C07D401/14 ,  C07D403/06 ,  C07D413/06 ,  C07D495/04

Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

Abstract translation: 公开了由以下结构（II）表示的化合物：制备这种化合物的方法。 还公开了用于治疗各种疾病状况（包括与血管增生相关的癌症和非癌症疾病）的组合物和方法。

公开(公告)号：US06278030B1

公开(公告)日：2001-08-21

申请号：US09483067

申请日：2000-01-14

Applicant: Jose Manuel Vargas ,  Kenneth Lloyd Riley

Inventor： Jose Manuel Vargas ,  Kenneth Lloyd Riley

IPC: C07C2916

CPC classification number: B01J23/002 ,  B01J23/85 ,  B01J23/88 ,  B01J23/883 ,  B01J23/8878 ,  B01J23/888 ,  B01J23/8885 ,  B01J37/03 ,  B01J37/082 ,  B01J2523/00 ,  C07C29/16 ,  C08F8/00 ,  C08F8/04 ,  C08F8/50 ,  C10G45/08 ,  C10G45/16 ,  C10G47/04 ,  C10G65/04 ,  C10G65/08 ,  C10G65/12 ,  C10G2400/10 ,  C10G2400/14 ,  C08F240/00 ,  B01J2523/68 ,  B01J2523/69 ,  B01J2523/847 ,  B01J2523/842 ,  B01J2523/67 ,  B01J2523/31 ,  B01J2523/41 ,  C07C31/125

Abstract: An improved process for preparing alcohols by the Oxo process. More particularly this invention relates to an improvement in the hydrogenation step of the Oxo process characterized in the use of certain bulk multimetallic hydrogenation catalysts comprised of at least one Group VIII non-noble metal and at least two Group VIB metals.

Abstract translation: 通过Oxo方法制备醇的改进方法。 更具体地说，本发明涉及Oxo方法的氢化步骤的改进，其特征在于使用由至少一种VIII族非贵金属和至少两种VIB族金属组成的某些本体多金属氢化催化剂。

公开(公告)号：US07586017B2

公开(公告)日：2009-09-08

申请号：US10582742

申请日：2004-12-16

Applicant: Eddy Theophyle Andrea Van Driessche ,  Philippe Louis Buess ,  Raphael Frans Caers ,  Arie Van Vliet ,  Ramzi Yanni Saleh ,  Jose Manuel Vargas ,  Kenneth Lloyd Riley ,  Magdiel Agosto

Inventor： Eddy Theophyle Andrea Van Driessche ,  Philippe Louis Buess ,  Raphael Frans Caers ,  Arie Van Vliet ,  Ramzi Yanni Saleh ,  Jose Manuel Vargas ,  Kenneth Lloyd Riley ,  Magdiel Agosto

IPC: C07C29/141

CPC classification number: C07C29/16 ,  C07C11/02 ,  C07C29/141 ,  C07C29/175 ,  C07C45/50 ,  C07C31/125 ,  C07C47/02

Abstract: The use of a controlled amount of water in a hydrogenation stage of the oxo process for the production of alcohols which uses at least two reactors in series improves the efficiency of the hydrogenation reaction and catalyst life as does a reduction in the amount of sulphur, chlorine and hydroformylation catalyst residues in the feed to hydrogenation.

Abstract translation: 在氧化方法的氢化阶段中使用受控量的水来生产使用至少两个串联的反应器的醇的提高氢化反应和催化剂寿命的效率，同时硫，氯的量的减少 和加氢甲酰化催化剂残余物在进料中进行氢化。