公开(公告)号：US08148348B2

公开(公告)日：2012-04-03

申请号：US12161030

申请日：2007-01-16

申请人： Kentarou Takano ,  Shinyo Gayama

发明人： Kentarou Takano ,  Shinyo Gayama

IPC分类号： A61K31/7076 ,  A61K31/341 ,  A61K31/10

CPC分类号： A61K47/22 ,  A61K9/19 ,  A61K31/7076 ,  C07H19/167

摘要： Provided are a process for producing a S-adenosyl-L-methionine-containing composition which is very excellent in a stability by adding at least ascorbic acids or salts thereof to a composition liquid containing S-adenosyl-L-methionine and then drying the above composition liquid or separating and drying a crystallized deposit obtained from the above composition liquid, a S-adenosyl-L-methionine-containing composition obtained by the above production process and a molding obtained from the above composition.

摘要翻译： 本发明提供一种生产含有S-腺苷-L-甲硫氨酸的组合物的方法，该组合物通过至少将抗坏血酸或其盐加入到含有S-腺苷-L-甲硫氨酸的组合物液中，然后将上述干燥 分离和干燥由上述组合物液获得的结晶沉积物，通过上述制备方法获得的含有S-腺苷-L-甲硫氨酸的组合物和由上述组合物获得的模塑。

公开(公告)号：US20100168048A1

公开(公告)日：2010-07-01

申请号：US12161030

申请日：2007-01-16

申请人： Kentarou Takano ,  Shinyo Gayama

发明人： Kentarou Takano ,  Shinyo Gayama

IPC分类号： A61K31/7076 ,  A61P43/00

CPC分类号： A61K47/22 ,  A61K9/19 ,  A61K31/7076 ,  C07H19/167

摘要： Provided are a process for producing a S-adenosyl-L-methionine-containing composition which is very excellent in a stability by adding at least ascorbic acids or salts thereof to a composition liquid containing S-adenosyl-L-methionine and then drying the above composition liquid or separating and drying a crystallized deposit obtained from the above composition liquid, a S-adenosyl-L-methionine-containing composition obtained by the above production process and a molding obtained from the above composition.

摘要翻译： 本发明提供一种生产含有S-腺苷-L-甲硫氨酸的组合物的方法，该组合物通过至少将抗坏血酸或其盐加入到含有S-腺苷-L-甲硫氨酸的组合物液中，然后将上述干燥 分离和干燥由上述组合物液获得的结晶沉积物，通过上述制备方法获得的含有S-腺苷-L-甲硫氨酸的组合物和由上述组合物获得的模塑。

公开(公告)号：US09404076B2

公开(公告)日：2016-08-02

申请号：US13639700

申请日：2011-04-05

申请人： Kentarou Takano ,  Shinyo Gayama

发明人： Kentarou Takano ,  Shinyo Gayama

IPC分类号： A23L1/28 ,  A61K36/06 ,  C12N1/16 ,  C12P19/40 ,  C12N1/04

CPC分类号： C12N1/16 ,  C12N1/04 ,  C12P19/40

摘要： A dry yeast composition which includes 5-adenosyl-L-methionine and a thickener and has excellent storage stability. A thickener is added to a yeast cell concentrate obtained by culturing yeast which has SAMe-producing ability and collecting the cells, and the resultant mixture is dried. Thus, a dry yeast containing a high concentration of 5-adenosyl-L-methionine which has excellent storage stability and excellent bioabsorbability can be easily and profitably produced. It is hence possible to supply a market with a dry yeast composition that contains a high concentration of 5-adenosyl-L-methionine, which is useful as a water-soluble physiologically active substance, and that has excellent storage stability and bioabsorbability.

摘要翻译： 一种干酵母组合物，其包含5-腺苷-L-甲硫氨酸和增稠剂，并且具有优异的储存稳定性。 向通过培养具有SAMe产生能力并收集细胞的酵母获得的酵母细胞浓缩物中加入增稠剂，并将所得混合物干燥。 因此，可以容易且有利地生产具有优异的储存稳定性和优异的生物吸收性的含有高浓度的5-腺苷-L-甲硫氨酸的干酵母。 因此，可以向市场提供含有高浓度的5-腺苷-L-甲硫氨酸的干酵母组合物，其可用作水溶性生理活性物质，并且具有优异的储存稳定性和生物吸收性。

公开(公告)号：US09200250B2

公开(公告)日：2015-12-01

申请号：US12524050

申请日：2008-01-23

申请人： Kentarou Takano ,  Shinyo Gayama

发明人： Kentarou Takano ,  Shinyo Gayama

IPC分类号： C12N1/16 ,  C12N1/18 ,  A23L1/30 ,  C12N1/04

CPC分类号： C12N1/18 ,  A23L33/13 ,  A23L33/14 ,  A23V2002/00 ,  C12N1/04 ,  A23V2250/218 ,  A23V2250/312

摘要： The present invention relates to a method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, the method containing: adding a cyclodextrin compound to a yeast concentrate obtained from a fungus culture liquid of the yeast; and then drying the concentrate, an SAMe-containing dry yeast obtained by the production method, and a composition formed by molding the dry yeast. According to the present invention, a dry yeast containing S-adenosyl-L-methionine, which is useful as an aqueous physiologically active substance, in a high concentration excellent in storage stability and a composition obtained by molding the dry yeast can be produced conveniently and economically and can be brought into the market.

摘要翻译： 本发明涉及使用具有S-腺苷-L-甲硫氨酸生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，该方法包括：将环糊精化合物加入到由 酵母真菌培养液; 然后干燥浓缩物，通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的组合物。 根据本发明，可以方便地制造含有S-作为生理活性物质的S-腺苷-L-甲硫氨酸的干酵母，其贮藏稳定性优异的高浓度和通过成型干酵母获得的组合物， 在经济上可以进入市场。

公开(公告)号：US09080158B2

公开(公告)日：2015-07-14

申请号：US12300826

申请日：2007-05-15

申请人： Kentarou Takano ,  Shinyo Gayama

发明人： Kentarou Takano ,  Shinyo Gayama

IPC分类号： C12N1/12 ,  C12N1/20 ,  A01N63/00 ,  C12N1/18 ,  A61K9/16 ,  A61K9/19 ,  C07H19/167 ,  C12N1/04 ,  C12P19/40

CPC分类号： C12N1/18 ,  A61K9/1617 ,  A61K9/19 ,  C07H19/167 ,  C12N1/04 ,  C12P19/40

摘要： A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which an ascorbic acid compound or a salt thereof is added to a yeast concentrate separated from a fungus culture liquid of the yeast, and the concentrate is then dried, a dry yeast containing SAMe obtained by the production method, and a composition for oral ingestion formed by molding the dry yeast. A method capable of producing a dry yeast containing SAMe in a high concentration excellent in storage stability conveniently at low cost is established, and a dry yeast containing SAMe obtained by the production method and a composition for oral ingestion formed by molding the dry yeast are provided.

摘要翻译： 使用具有S-腺苷-L-甲硫氨酸的生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，其中将抗坏血酸化合物或其盐加入从真菌分离的酵母浓缩物中 培养液，然后干燥浓缩物，通过制备方法得到的含有SAMe的干酵母和通过模制干酵母形成的用于口服摄取的组合物。 建立了能够以低成本方便地生产具有优异的储存稳定性高的SAMe的干酵母的方法，并且提供了通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的口服摄取组合物 。

公开(公告)号：US20140377242A1

公开(公告)日：2014-12-25

申请号：US14484800

申请日：2014-09-12

申请人： Rieko NAKANO ,  Midori Kikuchi ,  Kentarou Takano

发明人： Rieko NAKANO ,  Midori Kikuchi ,  Kentarou Takano

IPC分类号： A61K31/122 ,  A61K47/46 ,  A23L1/30 ,  A61K47/42

CPC分类号： A61K31/122 ,  A23L33/10 ,  A23V2002/00 ,  A61K36/48 ,  A61K47/42 ,  A61K47/46

摘要： Disclosed are: a coenzyme Q10 composition for oral ingestion which improves the bioabsorbability of coenzyme Q10 and enables efficient ingestion of coenzyme Q10 and which is highly safe, and a pharmaceutical preparation and a functional food containing the composition for oral ingestion. Combining coenzyme Q10 and a seed processed product has made it possible to provide a coenzyme Q10-containing composition for oral ingestion excellent in bioabsorbability, and a pharmaceutical preparation and a functional food containing the composition for oral ingestion.

摘要翻译： 公开了一种口服摄取的辅酶Q10组合物，其提高了辅酶Q10的生物吸收性，能够高效摄取辅酶Q10，其是高度安全的，以及含有口服摄取组合物的药物制剂和功能性食品。 联合辅酶Q10和种子加工产品使得可以提供具有优异生物吸收性的口服摄取用辅酶Q10组合物，以及含有口服摄取组合物的药物制剂和功能性食品。

公开(公告)号：US20110311504A1

公开(公告)日：2011-12-22

申请号：US13203129

申请日：2010-02-26

申请人： Rieko Nakano ,  Midori Kikuchi ,  Kentarou Takano

发明人： Rieko Nakano ,  Midori Kikuchi ,  Kentarou Takano

IPC分类号： A61K31/122 ,  A61P9/00

CPC分类号： A61K31/122 ,  A23L33/10 ,  A23V2002/00 ,  A61K36/48 ,  A61K47/42 ,  A61K47/46

摘要： Disclosed are: a coenzyme Q10 composition for oral ingestion which improves the bioabsorbability of coenzyme Q10 and enables efficient ingestion of coenzyme Q10 and which is highly safe, and a pharmaceutical preparation and a functional food containing the composition for oral ingestion. Combining coenzyme Q10 and a seed processed product has made it possible to provide a coenzyme Q10-containing composition for oral ingestion excellent in bioabsorbability, and a pharmaceutical preparation and a functional food containing the composition for oral ingestion.

摘要翻译： 公开了一种口服摄取的辅酶Q10组合物，其提高了辅酶Q10的生物吸收性，能够高效摄取辅酶Q10，其是高度安全的，以及含有口服摄取组合物的药物制剂和功能性食品。 联合辅酶Q10和种子加工产品使得可以提供具有优异生物吸收性的口服摄取用辅酶Q10组合物，以及含有口服摄取组合物的药物制剂和功能性食品。

公开(公告)号：US20090186400A1

公开(公告)日：2009-07-23

申请号：US12300826

申请日：2007-05-15

申请人： Kentarou Takano ,  Shinyo Gayama

发明人： Kentarou Takano ,  Shinyo Gayama

IPC分类号： C12N1/02 ,  C12N1/16

CPC分类号： C12N1/18 ,  A61K9/1617 ,  A61K9/19 ,  C07H19/167 ,  C12N1/04 ,  C12P19/40

摘要： A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which an ascorbic acid compound or a salt thereof is added to a yeast concentrate separated from a fungus culture liquid of the yeast, and the concentrate is then dried, a dry yeast containing SAMe obtained by the production method, and a composition for oral ingestion formed by molding the dry yeast. A method capable of producing a dry yeast containing SAMe in a high concentration excellent in storage stability conveniently at low cost is established, and a dry yeast containing SAMe obtained by the production method and a composition for oral ingestion formed by molding the dry yeast are provided.

摘要翻译： 使用具有S-腺苷-L-甲硫氨酸的生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，其中将抗坏血酸化合物或其盐加入从真菌分离的酵母浓缩物中 培养液，然后干燥浓缩物，通过制备方法得到的含有SAMe的干酵母和通过模制干酵母形成的用于口服摄取的组合物。 建立了能够以低成本方便地生产具有优异的储存稳定性高的SAMe的干酵母的方法，并且提供了通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的口服摄取组合物 。

公开(公告)号：US20130028878A1

公开(公告)日：2013-01-31

申请号：US13639700

申请日：2011-04-05

申请人： Kentarou Takano ,  Shinyo Gayama

发明人： Kentarou Takano ,  Shinyo Gayama

IPC分类号： A61K36/06 ,  A23L1/28

CPC分类号： C12N1/16 ,  C12N1/04 ,  C12P19/40

摘要： A dry yeast composition which includes 5-adenosyl-L-methionine and a thickener and has excellent storage stability. A thickener is added to a yeast cell concentrate obtained by culturing yeast which has SAMe-producing ability and collecting the cells, and the resultant mixture is dried. Thus, a dry yeast containing a high concentration of 5-adenosyl-L-methionine which has excellent storage stability and excellent bioabsorbability can be easily and profitably produced. It is hence possible to supply a market with a dry yeast composition that contains a high concentration of 5-adenosyl-L-methionine, which is useful as a water-soluble physiologically active substance, and that has excellent storage stability and bioabsorbability.

摘要翻译： 一种干酵母组合物，其包含5-腺苷-L-甲硫氨酸和增稠剂，并且具有优异的储存稳定性。 向通过培养具有SAMe产生能力并收集细胞的酵母获得的酵母细胞浓缩物中加入增稠剂，并将所得混合物干燥。 因此，可以容易且有利地生产具有优异的储存稳定性和优异的生物吸收性的含有高浓度的5-腺苷-L-甲硫氨酸的干酵母。 因此，可以向市场提供含有高浓度的5-腺苷-L-甲硫氨酸的干酵母组合物，其可用作水溶性生理活性物质，并且具有优良的储存稳定性和生物吸收性。

公开(公告)号：US08202515B2

公开(公告)日：2012-06-19

申请号：US12299942

申请日：2007-05-08

申请人： Kentarou Takano ,  Shinyo Gayama ,  Toshito Tsuchida

发明人： Kentarou Takano ,  Shinyo Gayama ,  Toshito Tsuchida

IPC分类号： A01N63/00

CPC分类号： A61K36/06 ,  A23L33/14 ,  A23L33/175 ,  C12N1/16 ,  C12P19/40

摘要： A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which a yeast cell concentrate separated from a cell culture liquid of the yeast is subjected to at least one treatment of (1) a treatment of adding a mineral acid to adjust the pH of the concentrate to 1 to 5, and (2) a treatment of heating the concentrate to 40 to 85° C., and then dried, and a composition for oral ingestion containing a dry yeast produced by the production method, having been molded. A method for producing dry yeast cells containing S-adenosyl-L-methionine, which is useful as a water soluble physiologically active substance, in a high concentration with a good yield at low cost, and a composition for oral ingestion formed by molding a dry yeast produced by the production method can be provided.

摘要翻译： 使用具有S-腺苷-L-甲硫氨酸生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，其中将从酵母的细胞培养液中分离的酵母细胞浓缩物至少 一种处理（1）加入无机酸以将浓缩物的pH调节至1至5的处理，和（2）将浓缩物加热至40至85℃的处理，然后干燥，并将组合物 用于口服摄入，其含有通过制造方法生产的干酵母，已经被模制。 以低成本以高收率高浓度生产可用作水溶性生理活性物质的S-腺苷-L-甲硫氨酸的干酵母细胞的方法，以及通过模制干燥形成的口服摄取组合物 可以提供通过制造方法生产的酵母。