公开(公告)号：US20080021368A1

公开(公告)日：2008-01-24

申请号：US10593855

申请日：2005-03-23

Applicant: Lakshmi Prasad Dasi ,  Kerem Pekkan ,  Diane De Julien De Zelicourt ,  Ajit P. Yoganathan ,  Dennis Dam Soerensen

Inventor： Lakshmi Prasad Dasi ,  Kerem Pekkan ,  Diane De Julien De Zelicourt ,  Ajit P. Yoganathan ,  Dennis Dam Soerensen

IPC: A61M5/00

CPC classification number: A61F2/06 ,  A61F2002/068 ,  A61F2230/0054 ,  A61F2230/0056 ,  A61F2230/0058 ,  Y10T137/87249

Abstract: A device for use in the total cavopulmonary connection (TCPC) in order to optimize its hemodynamics. Although the current procedure of choice for single ventricle heart repairs, the TCPC has reduced the post-operative mortality to the level of simpler types of congenital heart disease repairs, Fontan patients are still subjected to serious long-term complications. The TCPC procedure, which restores the vital separation between oxygenated and deoxygenated blood, also leads to an increased workload for the remaining single ventricle, as it is now responsible for pumping the blood through both the systemic and pulmonary circulation. The present device reduces this workload by altering the surgically created design of the TCPC. Improved fluid mechanics and reduced energy dissipation at the connection site translates into less work for the single ventricle and improved transport of deoxygenated blood to the lungs, which may in turn contribute to improved post-operative results and quality of life.

Abstract translation: 用于全肺静脉连接（TCPC）的装置，以优化其血流动力学。 虽然目前的单心室心脏修复方案是选择，但TCPC已经将术后死亡率降低到更简单类型的先天性心脏病修复水平，Fontan患者仍然遭受严重的长期并发症。 恢复氧合和脱氧血液之间重要分离的TCPC程序也导致剩余的单个心室的工作量增加，因为它现在负责通过全身和肺循环泵送血液。 本设备通过更改手术创建的TCPC设计来减少此工作负载。 改善的流体力学和减少的连接部位的能量消耗转化为较少的单一心室的工作和改善的脱氧血液转运到肺部，这可能反过来有助于改善术后结果和生活质量。

公开(公告)号：US20160278866A1

公开(公告)日：2016-09-29

申请号：US15035233

申请日：2014-07-11

Applicant: Senol PISKIN ,  Kerem PEKKAN ,  Mehmet Berk YIGIT

Inventor： Senol PISKIN ,  Kerem PEKKAN ,  Mehmet Berk YIGIT

IPC: A61B34/10 ,  G06F19/00 ,  A61B5/00 ,  A61B5/0444 ,  A61B5/021

CPC classification number: A61B34/10 ,  A61B5/0022 ,  A61B5/021 ,  A61B5/0444 ,  A61B2034/105 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378 ,  A61B2503/02 ,  A61B2503/045 ,  G16H10/40 ,  G16H10/60 ,  G16H40/20 ,  G16H50/50

Abstract: This invention is related to an operation scenario flow, mechanical modeling and analysis system comprising web based, (i) growth (ii) scaling and (iii) quality control aimed, patient based fast prototyping functions, for newborn and fetus cardiovascular repair operations, developed in order to be used for training of doctors and patient specific post surgery performance prediction in hospitals following and prior to, cardiovascular operations within the field of bioengineering in the health sector. Moreover it can be used for both vivo implantation plans of patient specific cardiovascular devices (custom cardiac valve and cardiac support pumps) and adaptation of said devices to the physiology of the patient.

Abstract translation: 本发明涉及一种包括基于网络的操作场景流程，机械建模和分析系统，（i）增长（ii）缩放和（iii）针对新生儿和胎儿心血管修复操作的基于患者的快速原型功能的质量控制，开发 为了在卫生部门的生物工程领域的心血管手术之前和之前，用于医生培训和患者具体的术后表现预测。 此外，它可以用于患者特异性心血管装置（定制心脏瓣膜和心脏支持泵）的体内植入计划以及将所述装置适应于患者的生理学。

公开(公告)号：US09585746B2

公开(公告)日：2017-03-07

申请号：US14235578

申请日：2012-07-30

Applicant: Masahiro Yoshida ,  C. Douglas Bernstein ,  Onur Dur ,  Kerem Pekkan

Inventor： Masahiro Yoshida ,  C. Douglas Bernstein ,  Onur Dur ,  Kerem Pekkan

IPC: A61F2/24 ,  A61L27/16 ,  A61L33/00 ,  A61F2/06

CPC classification number: A61F2/2412 ,  A61F2/06 ,  A61F2/2403 ,  A61F2/2409 ,  A61F2/2415 ,  A61F2/2475 ,  A61F2002/068 ,  A61F2250/0037 ,  A61F2250/0067 ,  A61F2250/0082 ,  A61L27/16 ,  A61L27/24 ,  A61L27/367 ,  A61L27/58 ,  A61L33/0011 ,  A61L2430/20 ,  Y10T29/49412 ,  C08L27/18

Abstract: Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient.

Abstract translation: 公开了人造心脏瓣膜结构及其制造方法。 心脏瓣膜结构可以由生物相容性聚合物制造并且包括结合在导管内的一个或多个心脏瓣膜小叶结构。 阀结构可以包括一个或多个导管窦，以及瓣膜小叶的下边缘和导管内部之间的间隙。 此外，阀结构可以包括在瓣膜小叶和导管内表面之间的空间中产生的一个或多个瓣膜窦。 计算流体动力学和机械建模可用于设计具有最佳特性的瓣叶。 心脏瓣膜结构还可以结合细胞可以附着的可生物降解的组分。掺入的细胞可能来自迁移到可生物降解的组分的患者细胞，或者该组分可以在植入患者体内之前用细胞预接种。

公开(公告)号：US20140288642A1

公开(公告)日：2014-09-25

申请号：US14235578

申请日：2012-07-30

Applicant: Masahiro Yoshida ,  C. Douglas Bernstein ,  Onur Dur ,  Kerem Pekkan

Inventor： Masahiro Yoshida ,  C. Douglas Bernstein ,  Onur Dur ,  Kerem Pekkan

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/06 ,  A61F2/2403 ,  A61F2/2409 ,  A61F2/2415 ,  A61F2/2475 ,  A61F2002/068 ,  A61F2250/0037 ,  A61F2250/0067 ,  A61F2250/0082 ,  A61L27/16 ,  A61L27/24 ,  A61L27/367 ,  A61L27/58 ,  A61L33/0011 ,  A61L2430/20 ,  Y10T29/49412 ,  C08L27/18

Abstract: Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap between the lower margin of the valve leaflets and the interior of the conduit. In addition, the valve structures may include one or more valve sinuses created in a space between the valve leaflets and the conduit inner surface. Computational fluid dynamics and mechanical modeling may be used to design the valve leaflets with optimal characteristics. A heart valve structure may also incorporate a biodegradable component to which cells may adhere The incorporated cells may arise from patient cells migrating to the biodegradable component, or the component may be pre-seeded with cells prior to implantation in a patient.

Abstract translation: 公开了人造心脏瓣膜结构及其制造方法。 心脏瓣膜结构可以由生物相容性聚合物制造并且包括结合在导管内的一个或多个心脏瓣膜小叶结构。 阀结构可以包括一个或多个导管窦，以及瓣膜小叶的下边缘和导管内部之间的间隙。 此外，阀结构可以包括在瓣膜小叶和导管内表面之间的空间中产生的一个或多个瓣膜窦。 计算流体动力学和机械建模可用于设计具有最佳特性的瓣叶。 心脏瓣膜结构还可以结合细胞可以附着的可生物降解的组分。结合的细胞可能来自迁移到可生物降解的组分的患者细胞，或者组分可以在植入患者体内之前用细胞预接种。